Výsledky vyhledávání - "Timm Heinbokel"

Akademický článek

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

Autor: Jasper Iske, Midas Seyda, Timm Heinbokel, Ryoichi Maenosono, Koichiro Minami, Yeqi Nian, Markus Quante, Christine S. Falk, Haruhito Azuma, Friederike Martin, João F. Passos, Claus U. Niemann, Tamara Tchkonia, James L. Kirkland, Abdallah Elkhal, Stefan G. Tullius

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Organ transplantation involving aged donors is often confounded by reduced post-transplantation organ survival. By studying both human organs and mouse transplantation models, here the authors show that pretreating the donors with senolytics to reduc

Externí odkaz: https://doaj.org/article/2a2a4da6a7984ebfa0d0c386e1408c60

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Akademický článek

Restored TDCA and valine levels imitate the effects of bariatric surgery

Publikováno v: eLife, Vol 10 (2021)

Background: Obesity is widespread and linked to various co-morbidities. Bariatric surgery has been identified as the only effective treatment, promoting sustained weight loss and the remission of co-morbidities. Methods: Metabolic profiling was perfo

Externí odkaz: https://doaj.org/article/634a24d4de31446badd10fcca144e2bd

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From Johann to Maurice: Science and Expression in the Philosophical Praxis of Medicine

Autor: Timm Heinbokel

Publikováno v: Human Studies. 44:559-579

Phenomenology’s return to lived experience and “to the things themselves” is often contrasted with the synthesized perspective of science and its “view from nowhere.” The extensive use of neuropsychological case reports in Merleau-Ponty’s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45020e69f61ba50bd59002d21c90b7a9
https://doi.org/10.1007/s10746-021-09605-3

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Restored TDCA and valine levels imitate the effects of bariatric surgery

Publikováno v: eLife
eLife, Vol 10 (2021)

Background:Obesity is widespread and linked to various co-morbidities. Bariatric surgery has been identified as the only effective treatment, promoting sustained weight loss and the remission of co-morbidities.Methods:Metabolic profiling was performe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec730a01a2b6c16989c586e8f0bedb9b
https://doi.org/10.7554/elife.62928

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Targeting age‐specific changes in CD4 + T cell metabolism ameliorates alloimmune responses and prolongs graft survival

Autor: Koichiro Minami, Stefan G. Tullius, Markus Quante, Hao Zhou, Ryoichi Maenosono, Timm Heinbokel, Jinrui Yang, Jasper Iske, Abdallah Elkhal, Yang Liu, Haruhito Azuma, Reza Abdi, Yeqi Nian

Publikováno v: Aging Cell

Age impacts alloimmunity. Effects of aging on T‐cell metabolism and the potential to interfere with immunosuppressants have not been explored yet. Here, we dissected metabolic pathways of CD4+ and CD8+ T cells in aging and offer novel immunosuppres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf4850b21600ff0d2e5d64213f18135
https://doi.org/10.1111/acel.13299

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Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

Autor: Friederike Martin, Stefan G. Tullius, Markus Quante, Yeqi Nian, James L. Kirkland, Koichiro Minami, Timm Heinbokel, Claus U. Niemann, Christine S. Falk, Midas Seyda, Tamara Tchkonia, Haruhito Azuma, Jasper Iske, Abdallah Elkhal, João F. Passos, Ryoichi Maenosono

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Older organs represent an untapped potential to close the gap between demand and supply in organ transplantation but are associated with age-specific responses to injury and increased immunogenicity, thereby aggravating transplant outcomes. Here we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a514abce1a7944a721ff7819556ed06
https://doi.org/10.1038/s41467-020-18039-x

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