Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Timm, KN"'
Autor:
Miller, JJ, Valkovič, L, Kerr, M, Timm, KN, Watson, WD, Lau, JYC, Tyler, A, Rodgers, C, Bottomley, PA, Heather, LC, Tyler, DJ
Publikováno v:
Miller, J J, Valkovič, L, Kerr, M, Timm, K N, Watson, W D, Lau, J Y C, Tyler, A, Rodgers, C, Bottomley, P A, Heather, L C & Tyler, D J 2021, ' Rapid, B 1-insensitive, dual-band quasi-adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux ', Magnetic Resonance in Medicine, vol. 85, no. 6, pp. 2978-2991 . https://doi.org/10.1002/mrm.28647
Purpose: Phosphorus saturation-transfer experiments can quantify metabolic fluxes non-invasively. Typically, the forward flux through the creatine-kinase reaction is investigated by observing the decrease in phosphocreatine (PCr) after saturation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79c935b299a76caa48d75d64af9b8a1
https://pure.au.dk/ws/files/274252216/Magnetic_Resonance_in_Med_2021_Miller_Rapid_u2010insensitive_dual_u2010band_quasi_u2010adiabatic_saturation_transfer_with_optimal.pdf
https://pure.au.dk/ws/files/274252216/Magnetic_Resonance_in_Med_2021_Miller_Rapid_u2010insensitive_dual_u2010band_quasi_u2010adiabatic_saturation_transfer_with_optimal.pdf
Autor:
Dodd, MS, Sousa Fialho, MDL, Montes Aparicio, CN, Kerr, M, Timm, KN, Griffin, JL, Luiken, JJFP, Glatz, JFC, Tyler, DJ, Heather, LC
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • HIF-1α is activated following myocardial infarction, and is a critical transcription factor promoting survival in hypoxia. • Type 2 diabetes blunts HIF-1α activation in ischemia and downstream adaptation to hyp
Highlights • HIF-1α is activated following myocardial infarction, and is a critical transcription factor promoting survival in hypoxia. • Type 2 diabetes blunts HIF-1α activation in ischemia and downstream adaptation to hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5b03523fcf1d2ee305e6c87916135e75
http://europepmc.org/articles/PMC6115650
http://europepmc.org/articles/PMC6115650
Autor:
Timm, KN, Hu, D-E, Williams, M, Wright, AJ, Kettunen, MI, Kennedy, BWC, Larkin, TJ, Dzien, P, Marco-Rius, I, Bohndiek, SE, Brindle, KM
Publikováno v:
The Journal of Biological Chemistry
Rapid cancer cell proliferation promotes the production of reducing equivalents, which counteract the effects of relatively high levels of reactive oxygen species (ROS). ROS levels increase in response to chemotherapy and cell death while an increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::63b6a00208ed668ee8a9e3e62723e8e5
https://www.repository.cam.ac.uk/handle/1810/263034
https://www.repository.cam.ac.uk/handle/1810/263034
Autor:
Timm, KN, Hu, D-E, Williams, M, Wright, AJ, Kettunen, MI, Kennedy, BWC, Larkin, TJ, Dzien, P, Marco-Rius, I, Bohndiek, SE, Brindle, KM
Rapid cancer cell proliferation promotes the production of reducing equivalents, which counteract the effects of relatively high levels of reactive oxygen species (ROS). ROS levels increase in response to chemotherapy and cell death while an increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a1cfa888936e4a898f9edc6a62e4aeb
Autor:
Malik MY; Department of Pharmacology, University of Oxford, Oxford, UK., Guo F; Department of Pharmacology, University of Oxford, Oxford, UK., Asif-Malik A; Department of Pharmacology, University of Oxford, Oxford, UK., Eftychidis V; Department of Pharmacology, University of Oxford, Oxford, UK., Barkas N; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, UK., Eliseeva E; Department of Pharmacology, University of Oxford, Oxford, UK., Timm KN; Department of Pharmacology, University of Oxford, Oxford, UK., Wolska A; Department of Pharmacology, University of Oxford, Oxford, UK., Bergin D; MRC Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Zonta B; Department of Pharmacology, University of Oxford, Oxford, UK., Ratz-Wirsching V; Department of Experimental Therapy and Preclinical Centre, University Hospital and Friedrich-Alexander-University (FAU), Erlangen, Germany., von Hörsten S; Department of Experimental Therapy and Preclinical Centre, University Hospital and Friedrich-Alexander-University (FAU), Erlangen, Germany., Walton ME; Department of Experimental Psychology, Oxford University, Oxford, UK.; Wellcome Centre for Integrative Neuroimaging, Oxford University, Oxford, UK., Magill PJ; MRC Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Nerlov C; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, UK., Minichiello L; Department of Pharmacology, University of Oxford, Oxford, UK. liliana.minichiello@pharm.ox.ac.uk.
Publikováno v:
Nature metabolism [Nat Metab] 2024 Nov; Vol. 6 (11), pp. 2100-2117. Date of Electronic Publication: 2024 Oct 28.
Autor:
Choksey A; Department of Physiology Anatomy and Genetics, University of Oxford, UK., Carter RD; Department of Physiology Anatomy and Genetics, University of Oxford, UK; Doctoral Training Centre, University of Oxford, Keble Road, Oxford, OX1 3NP, UK., Thackray BD; Department of Physiology Anatomy and Genetics, University of Oxford, UK., Ball V; Department of Physiology Anatomy and Genetics, University of Oxford, UK., Kennedy BWC; Department of Physiology Anatomy and Genetics, University of Oxford, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, UK., Ha LHT; Department of Pharmacology, University of Oxford, UK., Sharma E; Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7BN, UK., Broxholme J; Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7BN, UK., Castro-Guarda M; Department of Physiology Anatomy and Genetics, University of Oxford, UK., Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, UK., Heather LC; Department of Physiology Anatomy and Genetics, University of Oxford, UK., Tyler DJ; Department of Physiology Anatomy and Genetics, University of Oxford, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, UK., Timm KN; Department of Physiology Anatomy and Genetics, University of Oxford, UK; Department of Pharmacology, University of Oxford, UK. Electronic address: kerstin.timm@pharm.ox.ac.uk.
Publikováno v:
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2024 Jun; Vol. 191, pp. 12-22. Date of Electronic Publication: 2024 Apr 21.
Autor:
Eaton H; Merton College, University of Oxford, Merton St, Oxford, OX1 4JD, UK., Timm KN; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK. kerstin.timm@pharm.ox.ac.uk.
Publikováno v:
Cardio-oncology (London, England) [Cardiooncology] 2023 Apr 25; Vol. 9 (1), pp. 22. Date of Electronic Publication: 2023 Apr 25.
Metabolic Effects of Doxorubicin on the Rat Liver Assessed With Hyperpolarized MRI and Metabolomics.
Autor:
Timm KN; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.; Department of Pharmacology, University of Oxford, Oxford, United Kingdom., Ball V; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Miller JJ; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.; Department of Physics, University of Oxford, Oxford, United Kingdom.; Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, United Kingdom.; The MR Research Center, The PET Centre, Aarhus University Hospital, Aarhus University, Aarhus, Denmark., Savic D; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.; Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, United Kingdom., West JA; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom., Griffin JL; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom., Tyler DJ; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.; Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, United Kingdom.
Publikováno v:
Frontiers in physiology [Front Physiol] 2022 Jan 05; Vol. 12, pp. 782745. Date of Electronic Publication: 2022 Jan 05 (Print Publication: 2021).
Autor:
Choksey A; Somerville College, University of Oxford, Woodstock Road, Oxford OX2 6HD, UK., Timm KN; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Publikováno v:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 31; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 31.