Výsledky vyhledávání - "Timea Marton"

Akademický článek

The (Lack of) DNA Double-Strand Break Repair Pathway Choice During V(D)J Recombination

Autor: Alice Libri, Timea Marton, Ludovic Deriano

Publikováno v: Frontiers in Genetics, Vol 12 (2022)

DNA double-strand breaks (DSBs) are highly toxic lesions that can be mended via several DNA repair pathways. Multiple factors can influence the choice and the restrictiveness of repair towards a given pathway in order to warrant the maintenance of ge

Externí odkaz: https://doaj.org/article/68b8ecbf9ae548e2851d38c16056df6d

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Akademický článek

Multiple Stochastic Parameters Influence Genome Dynamics in a Heterozygous Diploid Eukaryotic Model

Autor: Timea Marton, Christophe d’Enfert, Melanie Legrand

Publikováno v: Journal of Fungi, Vol 8, Iss 7, p 650 (2022)

The heterozygous diploid genome of Candida albicans displays frequent genomic rearrangements, in particular loss-of-heterozygosity (LOH) events, which can be seen on all eight chromosomes and affect both laboratory and clinical strains. LOHs, which a

Externí odkaz: https://doaj.org/article/126a4847538044a6b28e431fdeb1427e

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Akademický článek

Use of CRISPR-Cas9 To Target Homologous Recombination Limits Transformation-Induced Genomic Changes in Candida albicans

Autor: Timea Marton, Corinne Maufrais, Christophe d’Enfert, Melanie Legrand

Publikováno v: mSphere, Vol 5, Iss 5 (2020)

ABSTRACT Most of our knowledge relating to molecular mechanisms of human fungal pathogenesis in Candida albicans relies on reverse genetics approaches, requiring strain engineering. DNA-mediated transformation of C. albicans has been described as hig

Externí odkaz: https://doaj.org/article/cdc40270ef2740f2a5459b3e3b97d217

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Akademický článek

Identification of Recessive Lethal Alleles in the Diploid Genome of a Candida albicans Laboratory Strain Unveils a Potential Role of Repetitive Sequences in Buffering Their Deleterious Impact

Autor: Timea Marton, Adeline Feri, Pierre-Henri Commere, Corinne Maufrais, Christophe d’Enfert, Melanie Legrand

Publikováno v: mSphere, Vol 4, Iss 1 (2019)

ABSTRACT The heterozygous diploid genome of Candida albicans is highly plastic, with frequent loss of heterozygosity (LOH) events. In the SC5314 laboratory strain, while LOH events are ubiquitous, a chromosome homozygosis bias is observed for certain

Externí odkaz: https://doaj.org/article/a4f19e583b0040988497b79b9662e61f

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Factors that influence bidirectional long-tract homozygosis due to double-strand break repair in Candida albicans

Autor: Murielle Chauvel, Adeline Feri, Corinne Maufrais, Mélanie Legrand, Christophe d'Enfert, Timea Marton

Publikováno v: Genetics
Genetics, 2021, 218 (1), pp.iyab028. ⟨10.1093/genetics/iyab028⟩

Genomic rearrangements have been associated with the acquisition of adaptive phenotypes, allowing organisms to efficiently generate new favorable genetic combinations. The diploid genome of Candida albicans is highly plastic, displaying numerous geno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5255a3cf9e8132550a32d8862e617c50
https://pubmed.ncbi.nlm.nih.gov/33705548

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Use of CRISPR-Cas9 To Target Homologous Recombination Limits Transformation-Induced Genomic Changes in Candida albicans

Autor: Christophe d'Enfert, Timea Marton, Corinne Maufrais, Mélanie Legrand

Publikováno v: mSphere
MSphere
MSphere, 2020, 5 (5), pp.e00620-20. ⟨10.1128/mSphere.00620-20⟩
mSphere, Vol 5, Iss 5 (2020)

Genome editing is essential to nearly all research studies aimed at gaining insight into the molecular mechanisms underlying various biological processes, including those in the opportunistic pathogen Candida albicans. The adaptation of the CRISPR-Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6360e1acbd4ef485f7ef66fbe44ff8ca
https://doi.org/10.1128/msphere.00620-20

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Limited Tumor Tissue Drug Penetration Contributes to Primary Resistance against Angiogenesis Inhibitors

Autor: Ildiko Kovacs, Olga Kelemen, Sándor Paku, Walter Klepetko, Yutaka Sugihara, Melinda Rezeli, György Marko-Varga, Balazs Hegedus, Anna Tisza, Mir Alireza Hoda, Thomas H. Helbich, Timea Marton, Ákos Végvári, Thomas Klikovits, Ken-ichi Watanabe, Viktoria Laszlo, Balazs Dome, József Tóvári, Szilvia Török

Publikováno v: Theranostics

Resistance mechanisms against antiangiogenic drugs are unclear. Here, we correlated the antitumor and antivascular properties of five different antiangiogenic receptor tyrosine kinase inhibitors (RTKIs) (motesanib, pazopanib, sorafenib, sunitinib, va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54ab36de60c7463a7ff7572bd4c46ec
https://doi.org/10.7150/thno.16767

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Identification of recessive lethal alleles in the diploid genome of a candida albicans laboratory strain unveils a potential role of repetitive sequences in buffering their deleterious impact

Autor: Corinne Maufrais, Christophe d'Enfert, Timea Marton, Adeline Feri, Pierre-Henri Commere, Mélanie Legrand

Publikováno v: MSphere
MSphere, American Society for Microbiology., 2019, 4 (1), pp.e00709-18. ⟨10.1128/mSphere.00709-18⟩
mSphere 1 (4), 1-17. (2019)
MSphere, 2019, 4 (1), pp.e00709-18. ⟨10.1128/mSphere.00709-18⟩
mSphere, Vol 4, Iss 1 (2019)
mSphere
mSphere, Vol 4, Iss 1, p e00709-18 (2019)

Candida albicans is a major fungal pathogen, whose mode of reproduction is mainly clonal. Its genome is highly tolerant to rearrangements, in particular loss of heterozygosity events, known to unmask recessive lethal and deleterious alleles in hetero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e22a0fe5f012f362e246e979b4e82d9
https://hal.inrae.fr/hal-02619101/file/2019_Marton_mSphere_1.pdf

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High intraspecific genome diversity in the model arbuscular mycorrhizal symbiont Rhizophagus irregularis

Autor: Christophe Roux, Jessica Noël, Philippe Charron, Steve Ndikumana, Camille St‐Onge, Nicolas Corradi, Francis Martin, Denis Beaudet, Manuela Krüger, Gokalp Yildirir, Emmanuelle Morin, John M Giorgi, Eric C. H. Chen, Igor V. Grigoriev, Timea Marton, Matthieu Hainaut, Jeanne Ropars, Bernard Henrissat

Publikováno v: New Phytologist
New Phytologist, Wiley, 2018, 220 (4), pp.1161-1171. ⟨10.1111/nph.14989⟩
New Phytologist, 2018, 220 (4), pp.1161-1171. ⟨10.1111/nph.14989⟩

International audience; Arbuscular mycorrhizal fungi (AMF) are known to improve plant fitness through the establishment of mycorrhizal symbioses. Genetic and phenotypic variations among closely related AMF isolates can significantly affect plant grow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27ed196daaa87fb09dfe9c058e77812
https://hal.archives-ouvertes.fr/hal-02018426

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Genome Diversity and Dynamics in Candida albicans

Autor: Marie-Elisabeth Bougnoux, Emilie Sitterlé, Natacha Sertour, Adeline Feri, Jeanne Ropars, Mélanie Legrand, Corinne Maufrais, Raphaël Loll-Krippleber, Christophe d'Enfert, Timea Marton

Publikováno v: Candida albicans: Cellular and Molecular Biology ISBN: 9783319504087

The fungal pathogen Candida albicans shows significant diversity at the genetic and phenotypic levels. In this Chapter, we review our current knowledge of the C. albicans diploid genome and its variability, the genetic structure of the C. albicans po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31c6081f78956ea0d22bcd3db7423a11
https://doi.org/10.1007/978-3-319-50409-4_11

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