Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Timea Imre"'
Autor:
Zsófia Varga-Medveczky, Noémi Kovács, Melinda E. Tóth, Miklós Sántha, Ildikó Horváth, Luca Anna Bors, Katalin Fónagy, Timea Imre, Pál Szabó, Domokos Máthé, Franciska Erdő
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Increased blood–brain barrier (BBB) permeability and extensive neuronal changes have been described earlier in both healthy and pathological aging like apolipoprotein B-100 (APOB-100) and amyloid precursor protein (APP)–presenilin-1 (PSEN1) trans
Externí odkaz:
https://doaj.org/article/80f18d5de08c4131af27e6b7231b4ecf
Autor:
Dániel Bálint, Ádám Levente Póti, Anita Alexa, Péter Sok, Krisztián Albert, Lili Torda, Dóra Földesi-Nagy, Dániel Csókás, Gábor Turczel, Tímea Imre, Eszter Szarka, Ferenc Fekete, Isabel Bento, Márton Bojtár, Roberta Palkó, Pál Szabó, Katalin Monostory, Imre Pápai, Tibor Soós, Attila Reményi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract There has been a surge of interest in covalent inhibitors for protein kinases in recent years. Despite success in oncology, the off-target reactivity of these molecules is still hampering the use of covalent warhead-based strategies. Herein,
Externí odkaz:
https://doaj.org/article/a3e63eb44b28449ba2031704dd9ee83f
Autor:
Ádám Levente Póti, Dániel Bálint, Anita Alexa, Péter Sok, Kristóf Ozsváth, Krisztián Albert, Gábor Turczel, Sarolt Magyari, Orsolya Ember, Kinga Papp, Sándor Balázs Király, Tímea Imre, Krisztina Németh, Tibor Kurtán, Gergő Gógl, Szilárd Varga, Tibor Soós, Attila Reményi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract For mitogen-activated protein kinases (MAPKs) a shallow surface—distinct from the substrate binding pocket—called the D(ocking)-groove governs partner protein binding. Screening of broad range of Michael acceptor compounds identified a d
Externí odkaz:
https://doaj.org/article/4603a495845c41f6a42a040ea8d5d6e0
Autor:
Péter Ábrányi-Balogh, Dávid Bajusz, Zoltán Orgován, Aaron B. Keeley, László Petri, Nikolett Péczka, Tibor Viktor Szalai, Gyula Pálfy, Márton Gadanecz, Emma K. Grant, Tímea Imre, Tamás Takács, Ivan Ranđelović, Marcell Baranyi, András Marton, Gitta Schlosser, Qirat F. Ashraf, Elvin D. de Araujo, Tamás Karancsi, László Buday, József Tóvári, András Perczel, Jacob T. Bush, György M. Keserű
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Fragment screening is a popular strategy of generating viable chemical starting points especially for challenging targets. Although fragments provide a better coverage of chemical space and they have typically higher chance of binding, their
Externí odkaz:
https://doaj.org/article/0a79f05dcd144d4ba343eaa1f806db99
Autor:
Levente Kollár, Katarina Grabrijan, Martina Hrast Rambaher, Krištof Bozovičar, Tímea Imre, György G. Ferenczy, Stanislav Gobec, György M. Keserű
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractPenicillin-binding proteins (PBPs) contribute to bacterial cell wall biosynthesis and are targets of antibacterial agents. Here, we investigated PBP1b inhibition by boronic acid derivatives. Chemical starting points were identified by structu
Externí odkaz:
https://doaj.org/article/3aa73b81e4b544ed9ddec929dc30123d
Akademický článek
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Publikováno v:
Synthetic Communications. 34:1033-1039
The reaction of 1,2‐dihydrophosphnine oxides (3a–3d) with tetracyanoethylene (TCNE) did not follow the Diels–Alder protocol, rather the corresponding diphosphatricyclododecatrienes (4a–4d) were formed in good yields. Interaction of the mesity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36480e842cd00ed689d9c1eab2cee37d
https://doi.org/10.1081/scc-120028634
https://doi.org/10.1081/scc-120028634
Publikováno v:
Journal of Inclusion Phenomena and Macrocyclic Chemistry. 38:435-443
Azacrown ethers with phosphonoalkyl-and phosphinoylalkyl side chains of two to five carbonatoms (2–4, 7 and 5–6, 8,respectively) were synthesized in acceptable yields.The cation binding ability of the new lariat etherswas evaluated by the picrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79a61a47380e80b970540f0b9dfc15d4
https://doi.org/10.1023/a:1008121328326
https://doi.org/10.1023/a:1008121328326
Autor:
Laszlo Toeke, Timea Imre, Krisztina Ludányi, Gyoergy Keglevich, Anikó Ujvári, Zoltán Zsolt Nagy, Henrietta Forintos
Publikováno v:
Journal of Chemical Research. 2004:432-434
The title phosphonium ylides give an ylidene oxolactone under reductive conditions and are unreactive towards aldehydes, but are degraded by hydroxylamine to form the simpler acetic ester phosphonium ylides that do react with aldehydes in the normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16369f0578f110c4c388ea9be53522b
https://doi.org/10.3184/0308234041423637
https://doi.org/10.3184/0308234041423637
Autor:
Kálmán Újszászy, Tibor Novák, Krisztina Ludányi, Péter Bakó, Gyoergy Keglevich, Laszlo Toke, Timea Imre
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb4830aa7ab0d3563a93521db35009dc
https://doi.org/10.1002/chin.200009170
https://doi.org/10.1002/chin.200009170