An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

Autor: Ilias Angelidis, Lukas M. Simon, Isis E. Fernandez, Maximilian Strunz, Christoph H. Mayr, Flavia R. Greiffo, George Tsitsiridis, Meshal Ansari, Elisabeth Graf, Tim-Matthias Strom, Monica Nagendran, Tushar Desai, Oliver Eickelberg, Matthias Mann, Fabian J. Theis, Herbert B. Schiller

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Aging impacts lung functionality and makes it more susceptible to chronic diseases. Combining proteomics and single cell transcriptomics, the authors chart molecular and cellular changes in the aging mouse lung, discover aging hallmarks, and predict

Externí odkaz: https://doaj.org/article/e8bbc178370d42f0a7884140d62b6b59

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

Autor: Isis E. Fernandez, Monica Nagendran, Tushar J. Desai, Maximilian Strunz, Tim-Matthias Strom, Fabian J. Theis, Christoph H. Mayr, Flavia R. Greiffo, Herbert B. Schiller, Elisabeth Graf, Ilias Angelidis, Meshal Ansari, George Tsitsiridis, Lukas M. Simon, Matthias Mann, Oliver Eickelberg

Publikováno v: Nat. Commun. 10:963 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Aging promotes lung function decline and susceptibility to chronic lung diseases, which are the third leading cause of death worldwide. Here, we use single cell transcriptomics and mass spectrometry-based proteomics to quantify changes in cellular ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27412d151c7f828d4fe4277414ffa10
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55599

Development of A Cell-Based Assay to Identify Small Molecule Inhibitors of FGF23 Signaling

Autor: Tim-Matthias Strom, Bettina Lorenz-Depiereux, Kenji Schorpp, Susanne Diener, Kamyar Hadian

Publikováno v: ASSAY and Drug Development Technologies. 13:476-487

Fibroblast growth factor 23 (FGF23) is a bone-derived endocrine key regulator of phosphate homeostasis. It inhibits renal tubular phosphate reabsorption by activating receptor complexes composed of FGF receptor 1c (FGFR1c) and the co-receptor Klotho.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deac79178b92d91e3074740e2833011a
https://doi.org/10.1089/adt.2015.653

Identification of Cadherin 2 (

Autor: Bongani M, Mayosi, Maryam, Fish, Gasnat, Shaboodien, Elisa, Mastantuono, Sarah, Kraus, Thomas, Wieland, Maria-Christina, Kotta, Ashley, Chin, Nakita, Laing, Ntobeko B A, Ntusi, Michael, Chong, Christopher, Horsfall, Simon N, Pimstone, Davide, Gentilini, Gianfranco, Parati, Tim-Matthias, Strom, Thomas, Meitinger, Guillaume, Pare, Peter J, Schwartz, Lia, Crotti

Publikováno v: Circulation. Cardiovascular genetics. 10(2)

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically heterogeneous condition caused by mutations in genes encoding desmosomal proteins in up to 60% of cases. The 40% of genotype-negative cases point to the need of identifying novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cafbf526f99dd1562feb99605d0c1e20
https://pubmed.ncbi.nlm.nih.gov/28280076

Common Genetic Variants Associate with Serum Phosphorus Concentration

Autor: Anna Köttgen, Bryan Kestenbaum, Eric Boerwinkle, Harry Campbell, Josef Coresh, Yii-Der Ida Chen, Shih-Jen Hwang, Caroline S. Fox, H.-Erich Wichmann, Dorothy B. Hausman, Qiong Yang, Christian Gieger, Yongmei Liu, Frank J.A. van Rooij, Janine F. Felix, Michael G. Shlipak, Kurt Lohman, Albert Hofman, Jacqueline C.M. Witteman, Caroline Hayward, David S. Siscovick, Tim Matthias Strom, Thomas Meitinger, Kenneth Rice, Cornelia M. van Duijn, Abbas Dehghan, Daniel Levy, Fernando Rivadeneira, Janina S. Ried, Man Li, Nicole L. Glazer, Ian H. de Boer, Ann Kristin Petersen, AndréG Uitterlinden, D.E. Arking, W. H. Linda Kao, Stephen B. Kritchevsky, Bruce M. Psaty, Igor Rudan

Publikováno v: Kestenbaum, B, Glazer, N L, Koettgen, A, Felix, J F, Hwang, S-J, Liu, Y, Lohman, K, Kritchevsky, S B, Hausman, D B, Petersen, A-K, Gieger, C, Ried, J S, Meitinger, T, Strom, T M, Wichmann, H E, Campbell, H, Hayward, C, Rudan, I, de Boer, I H, Psaty, B M, Rice, K M, Chen, Y-D I, Li, M, Arking, D E, Boerwinkle, E, Coresh, J, Yang, Q, Levy, D, van Rooij, F J A, Dehghan, A, Rivadeneira, F, Uitterlinden, A G, Hofman, A, van Duijn, C M, Shlipak, M G, Kao, W H L, Witteman, J C M, Siscovick, D S & Fox, C S 2010, ' Common Genetic Variants Associate with Serum Phosphorus Concentration ', Journal of the American Society of Nephrology, vol. 21, no. 7, pp. 1223-1232 . https://doi.org/10.1681/ASN.2009111104
Journal of the American Society of Nephrology, 21(7), 1223-1232. American Society of Nephrology

Phosphorus is an essential mineral that maintains cellular energy and mineralizes the skeleton. Because complex actions of ion transporters and regulatory hormones regulate serum phosphorus concentrations, genetic variation may determine interindivid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb675ae9b7ab2420b0d0a263c3666dc
https://hdl.handle.net/20.500.11820/d3651d89-56ec-4313-92d0-f332f93f355c