A molecular view of amyotrophic lateral sclerosis through the lens of interaction network modules.

Autor: Klaus Højgaard Jensen, Anna Katharina Stalder, Rasmus Wernersson, Tim-Christoph Roloff-Handschin, Daniel Hvidberg Hansen, Peter M A Groenen

Publikováno v: PLoS ONE, Vol 17, Iss 5, p e0268159 (2022)

BackgroundDespite the discovery of familial cases with mutations in Cu/Zn-superoxide dismutase (SOD1), Guanine nucleotide exchange C9orf72, TAR DNA-binding protein 43 (TARDBP) and RNA-binding protein FUS as well as a number of other genes linked to A

Externí odkaz: https://doaj.org/article/a21989d6f00e4ec9b08c17a084d8aab6

Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice.

Autor: Harri Lempiäinen, Arne Müller, Sarah Brasa, Soon-Siong Teo, Tim-Christoph Roloff, Laurent Morawiec, Natasa Zamurovic, Axel Vicart, Enrico Funhoff, Philippe Couttet, Dirk Schübeler, Olivier Grenet, Jennifer Marlowe, Jonathan Moggs, Rémi Terranova

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e18216 (2011)

Evidence suggests that epigenetic perturbations are involved in the adverse effects associated with some drugs and toxicants, including certain classes of non-genotoxic carcinogens. Such epigenetic changes (altered DNA methylation and covalent histon

Externí odkaz: https://doaj.org/article/556aff167f6c4c64ad5b0e16f9a0ec15

A Molecular View of Amyotrophic Lateral Sclerosis Through the Lens of Interaction Network Modules

Autor: Klaus Højgaard Jensen, Anna Katharina Stalder, Rasmus Wernersson, Tim-Christoph Roloff-Handschin, Daniel Hvidberg Hansen, Peter M. A. Groenen

Publikováno v: Jensen, K H, Stalder, A K, Wernersson, R, Roloff-Handschin, T C, Hansen, D H & Groenen, P M A 2022, ' A molecular view of amyotrophic lateral sclerosis through the lens of interaction network modules ', PLOS ONE, vol. 17, no. 5, e0268159 . https://doi.org/10.1371/journal.pone.0268159

Background: Despite the discovery of familial cases with mutations in Cu/Zn-superoxide dismutase (SOD1), Guanine nucleotide exchange C9orf72, TAR DNA-binding protein 43 (TARDBP) and RNA-binding protein FUS as well as a number of other genes linked to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf79343580d72d5af21b54bd29ce3b1
https://doi.org/10.21203/rs.3.rs-656827/v2

Determinants of SARS-CoV-2 transmission to guide vaccination strategy in an urban area

Autor: Olivier Dubuis, Alexander Gensch, Manuel Battegay, Roland Bingisser, Hans H. Hirsch, Kirstine Kobberoee Soegaard, Sarah C. Brueningk, Madlen Stange, Adrian Egli, Karsten M. Borgwardt, Myrta Brunner, Julia Bielicki, Simon Fuchs, Tim-Christoph Roloff, Katharina Rentsch, Helena M. B. Seth-Smith, Nicole Ritz, Juliane Klatt, Andreas Buser, Ann-Kathrin Schlotterbeck, Ulrich Heininger, Sarah Tschudin-Sutter, Martin Siegemund, Alfredo Mari, Karoline Leuzinger, Christian H. Nickel, Hans Pargger, Michael Schweitzer, Diana Albertos Torres, Diana Ciardo, Rita Schneider-Sliwa

BackgroundTransmission chains within small urban areas (accommodating∼30% of the European population) greatly contribute to case burden and economic impact during the ongoing COVID-19 pandemic, and should be a focus for preventive measures to achie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11bc53400ca7a9644e7537962894f0aa
https://doi.org/10.1101/2020.12.15.20248130

Methylated DNA Immunoprecipitation (MeDIP)

Autor: Fabio Mohn, Dirk Schübeler, Michael Weber, Tim-Christoph Roloff

Publikováno v: Methods in Molecular Biology ISBN: 9781934115619

Methylated DNA immunoprecipitation (MeDIP) is a versatile immunocapturing approach for unbiased detection of methylated DNA. In brief, genomic DNA is randomly sheared by sonication and immunoprecipitated with a monoclonal antibody that specifically r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::397f44f286376efb7c7a9724d75985ce
https://doi.org/10.1007/978-1-59745-522-0_5