Zobrazeno 1 - 10
of 3 312
pro vyhledávání: '"Tim-3"'
Publikováno v:
Медицинская иммунология, Vol 26, Iss 5, Pp 1115-1120 (2024)
The T cell immunoglobulin domain and mucin domain-containing molecule-3 (TIM-3), an inhibitory checkpoint receptor, has been identified as a crucial regulator of cellular immune responses. TIM-3 has been discovered as a receptor involved in the negat
Externí odkaz:
https://doaj.org/article/15dbd7e19f9e4b9fa1a0e5151a391f90
Publikováno v:
Медицинская иммунология, Vol 26, Iss 5, Pp 913-918 (2024)
In multiple myeloma (MM), the content of T lymphocytes expressing “checkpoint” molecules PD-1, TIM-3, LAG-3, etc. is increased. Regulatory T cells (Treg) can suppress antitumor immune response and play a sufficient role in MM pathogenesis. Like e
Externí odkaz:
https://doaj.org/article/78595fada9e04f119cedc21e58527be4
Publikováno v:
Инфекция и иммунитет, Vol 14, Iss 3, Pp 575-580 (2024)
More than half of the world’s population is infected with the herpes simplex virus. In most cases, infection is not accompanied by symptoms, but in some people the disease occurs as a chronic infection with frequent and severe relapses. One of the
Externí odkaz:
https://doaj.org/article/272e250fdfe041de8ddecde8842befe7
Publikováno v:
Медицинская иммунология, Vol 26, Iss 4, Pp 801-806 (2024)
All types of immune cells are involved in the pathogenesis of multiple myeloma (MM). Granulocytic (G-MDSCs) and monocytic myeloid-derived suppressor cells (M-MDSCs) have significant protumor effects. The T cell immune response may be reduced due to t
Externí odkaz:
https://doaj.org/article/85e5d29bf5b443da9a6892713d0feb8a
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 7, Iss 2, Pp 89-96 (2024)
ABSTRACT: T cell immunoglobulin and mucin domain containing protein 3 (TIM-3) is a receptor found on a multitude of immune cells and is commonly overexpressed in patients with cancer. Due to its selective expression in immune cells and its preliminar
Externí odkaz:
https://doaj.org/article/0f622e8b361e4e079d39071f0762d20e
Publikováno v:
Hematology, Vol 29, Iss 1 (2024)
ABSTRACTBackground Immune checkpoints are receptors on the surface of T cells that function crucially in suppressing the immune response, and they are implicated in autoimmunity and cancer diseases.Aim The present study aimed to investigate the relat
Externí odkaz:
https://doaj.org/article/3b5170d4663d4d33bdaa0805795db7e2
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Xiangyu Chang, Jinwei Miao
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cell immunoglobulin and mucin domain-3 (TIM-3), a crucial immune checkpoint following PD1 and CTLA4, is widely found in several immune cells. Nonetheless, its performance in recent clinical trials appears disappointing. Ovarian cancer (OC), a malig
Externí odkaz:
https://doaj.org/article/1c829d2d042244c59bd70f44564220b9
Autor:
Hooriyeh Shapourian, Mustafa Ghanadian, Nahid Eskandari, Abolfazl Shokouhi, Gülderen Yanikkaya Demirel, Alexandr V. Bazhin, Mazdak Ganjalikhani-Hakemi
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is a cell surface molecule that was first discovered on T cells. However, recent studies revealed that it is also highly expressed in acute myeloid leukemia (AML) cells a
Externí odkaz:
https://doaj.org/article/784e5866227444c7bc445fc4f7feff9f
Autor:
Armin Akbar, Hossein asgariyan-Omran, Reza Valadan, Mohammad-Mehdi Dindarloo, Ahmad Najafi, Amir Kahrizi, Arash Poursheikhani, Hossein Karami, Mohammad Naderi, Shayan Sabeti, Mohsen Tehrani
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 26, Iss 12, Pp 1468-1474 (2023)
Objective(s): Exhausted CD8+ T-cells over-express immune checkpoint receptors (ICRs), which interact with their ligands on malignant cells. However, some ICRs have been reported to be expressed on both T-cells and tumor cells, including V-domain immu
Externí odkaz:
https://doaj.org/article/74445679839c4d0b93ec1a7434d52a26