A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma

Autor: Tim van Groningen, Nurdan Akogul, Ellen M. Westerhout, Alvin Chan, Nancy E. Hasselt, Danny A. Zwijnenburg, Marloes Broekmans, Peter Stroeken, Franciska Haneveld, Gerrit K. J. Hooijer, C. Dilara Savci-Heijink, Arjan Lakeman, Richard Volckmann, Peter van Sluis, Linda J. Valentijn, Jan Koster, Rogier Versteeg, Johan van Nes

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Neuroblastoma includes adrenergic and mesenchymal cell types that can interconvert. Here, the authors show that this transdifferentiation is driven by a NOTCH feedforward loop that allows a swift transition between two semi-stable cellular states.

Externí odkaz: https://doaj.org/article/514276fb271e42e0afc3df43c40d7742

Supplementary Legends from A NOTCH3 Transcriptional Module Induces Cell Motility in Neuroblastoma

Autor: Rogier Versteeg, Jan Koster, Peter van Sluis, Tim van Groningen, Alvin Chan, Johan van Nes

Supplementary Legends - PDF file 80K, This file contains the legends to supplementary figures, supplementary movies and supplementary tables

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449d7ebc3246391d48c04405886fb376
https://doi.org/10.1158/1078-0432.22451235

Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors

Autor: Rogier Versteeg, Johan van Nes, Linda J. Valentijn, Jan Koster, Tim van Groningen, Igor Adameyko, Carel J.M. van Noesel, Richard Volckmann, Danny Zwijnenburg, Peter van Sluis, Alvin Chan, Franciska Haneveld, Nurdan Akogul, Boris Bleijlevens, Nancy E. Hasselt, Jennemiek van Arkel, Arjan Lakeman, Natalia E. Nowakowska, Peter Stroeken, Mohamed Hamdi, Ellen M. Westerhout

Cancer therapy frequently fails due to the emergence of resistance. Many tumors include phenotypically immature tumor cells, which have been implicated in therapy resistance. Neuroblastoma cells can adopt a lineage-committed adrenergic (ADRN) or an i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b5f661dcd417faae73e178ff2f438c5
https://doi.org/10.1158/0008-5472.c.6513703.v1

Supplementary Figures from A NOTCH3 Transcriptional Module Induces Cell Motility in Neuroblastoma

Autor: Rogier Versteeg, Jan Koster, Peter van Sluis, Tim van Groningen, Alvin Chan, Johan van Nes

Supplementary Figures - PDF file 2758K, This file contains supplementary figure 1-7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291c17e2d795461dc1aba2f754721643
https://doi.org/10.1158/1078-0432.22451238

Therapeutic Strategies for Targeting CDKN2A Loss in Melanoma

Autor: Inger Z.M. Kreuger, Roderick C. Slieker, Tim van Groningen, Remco van Doorn

Publikováno v: Kreuger, I Z M, Slieker, R C, van Groningen, T & van Doorn, R 2023, ' Therapeutic Strategies for Targeting CDKN2A Loss in Melanoma ', Journal of Investigative Dermatology, vol. 143, no. 1, pp. 18-25.e1 . https://doi.org/10.1016/j.jid.2022.07.016

Loss of the tumor suppressor gene CDKN2A, encoding p16 and p14, is a frequent event driving melanoma progression. Therefore, therapeutic strategies aimed at CDKN2A loss hold great potential to improve melanoma treatment. Pharmacological inhibition of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4ee8bbc92ced49089ac85f65f8f44a
http://www.scopus.com/inward/record.url?scp=85138130043&partnerID=8YFLogxK