Personalised azithromycin+metronidazole (PAZAZ), in combination with standard induction therapy, to achieve a faecal microbiome community structure and metagenome changes associated with sustained remission in paediatric Crohn’s disease (CD): protocol of a pilot study

Autor: Marc A Benninga, Melvin B Heyman, Anthony Otley, Tim de Meij, Wouter J de Jonge, Charlotte M Verburgt, Katherine A Dunn, Sofia Verstraete, Withney Sunseri, Francisco Sylvester, Andre Comeau, Morgan Langille, Johan E Van Limbergen

Publikováno v: BMJ Open, Vol 13, Iss 2 (2023)

Introduction Early relapse in Crohn’s disease (CD) is associated with a more severe disease course. The microbiome plays a crucial role, yet strategies targeting the microbiome are underrepresented in current guidelines. We hypothesise that early m

Externí odkaz: https://doaj.org/article/6e3aa02899e64cd4a0a780130aa08935

Author Correction: Prediction of mortality in severe acute malnutrition in hospitalized children by faecal volatile organic compound analysis: proof of concept

Autor: Deborah A. van den Brink, Tim de Meij, Daniella Brals, Robert H. J. Bandsma, Johnstone Thitiri, Moses Ngari, Laura Mwalekwa, Nanne K. H. de Boer, Alfian Wicaksono, James A. Covington, Patrick F. van Rheenen, Wieger P. Voskuijl

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://doaj.org/article/abf8bbd8b38b477aa3282aa27e8f7aa3

Safety and Potential Efficacy of Escalating Dose of Ustekinumab in Pediatric Crohn Disease (the Speed-up Study)

Autor: Anat Yerushalmy-Feler, Gemma Pujol-Muncunill, Javier Martin-de-Carpi, Kaija-Leena Kolho, Arie Levine, Christine Olbjørn, Maya Granot, Matteo Bramuzzo, Helena Rolandsdotter, Natalia Mouratidou, Ondrej Hradsky, Luca Scarallo, Manar Matar, Ramit Magen Rimon, Firas Rinawi, Tzippi Shalem, Hisham Najajra, Tim de Meij, Marina Aloi, Marta Velasco Rodríguez-Belvís, Patrizia Alvisi, Anna-Maria Schneider, Patrick van Rheenen, Víctor Manuel Navas-López, Fevronia Kiparissi, Josefa Barrio, Dan Turner, Shlomi Cohen

Publikováno v: Journal of Pediatric Gastroenterology and Nutrition, 75(6), 717-723. Lippincott Williams and Wilkins
Yerushalmy-Feler, A, Pujol-Muncunill, G, Martin-de-Carpi, J, Kolho, K-L, Levine, A, Olbjørn, C, Granot, M, Bramuzzo, M, Rolandsdotter, H, Mouratidou, N, Hradsky, O, Scarallo, L, Matar, M, Rimon, R M, Rinawi, F, Shalem, T, Najajra, H, de Meij, T, Aloi, M, Rodríguez-Belvís, M V, Alvisi, P, Schneider, A-M, van Rheenen, P, Navas-López, V C M, Kiparissi, F, Barrio, J, Turner, D & Cohen, S 2022, ' Safety and Potential Efficacy of Escalating Dose of Ustekinumab in Pediatric Crohn Disease (the Speed-up Study) : A Multicenter Study from the Pediatric IBD Porto Group of ESPGHAN ', Journal of Pediatric Gastroenterology and Nutrition, vol. 75, no. 6, pp. 717-723 . https://doi.org/10.1097/MPG.0000000000003608

OBJECTIVES: Escalation of the ustekinumab (UST) maintenance dosage was effective in adults with Crohn disease (CD), but no data are available for children. We evaluated the effectiveness and safety of dose escalation of UST in pediatric CD. METHODS:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9790dae26a87ed87de98ba1e23fe231b
https://research.rug.nl/en/publications/a0741af3-0a6b-4f24-bc40-ec3617ad0395

Personalised azithromycin+metronidazole (PAZAZ), in combination with standard induction therapy, to achieve a faecal microbiome community structure and metagenome changes associated with sustained remission in paediatric Crohn's disease (CD):protocol of a pilot study

Autor: Charlotte M Verburgt, Katherine A Dunn, Anthony Otley, Melvin B Heyman, Sofia Verstraete, Withney Sunseri, Francisco Sylvester, Tim de Meij, Andre Comeau, Morgan Langille, Wouter J de Jonge, Marc A Benninga, Johan E Van Limbergen

Publikováno v: Verburgt, C M, Dunn, K A, Otley, A, Heyman, M B, Verstraete, S, Sunseri, W, Sylvester, F, de Meij, T, Comeau, A, Langille, M, de Jonge, W J, Benninga, M A & van Limbergen, J E 2023, ' Personalised azithromycin+metronidazole (PAZAZ), in combination with standard induction therapy, to achieve a faecal microbiome community structure and metagenome changes associated with sustained remission in paediatric Crohn's disease (CD) : protocol of a pilot study ', BMJ Open, vol. 13, no. 2, e064944, pp. e064944 . https://doi.org/10.1136/bmjopen-2022-064944
BMJ Open, 13(2):e064944. BMJ Publishing Group
BMJ open, 13(2). BMJ Publishing Group

IntroductionEarly relapse in Crohn’s disease (CD) is associated with a more severe disease course. The microbiome plays a crucial role, yet strategies targeting the microbiome are underrepresented in current guidelines. We hypothesise that early ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fe7e6f0d1a3d35a97586c4dbdf193a
https://research.vumc.nl/en/publications/5ab4bf17-a3ce-4d95-86dc-7cf5046b1865

Prediction of thiopurine failure in pediatric Crohn's disease: pediatric IBD Porto group of ESPGHAN

Autor: Tereza, Lerchova, Ondrej, Hradsky, Michal, Kulich, Gabor, Veres, Jorge Amil, Dias, Małgorzata, Sładek, Sanja, Kolacek, Stephanie, Van Biervliet, Jan, Melek, Daniela E, Serban, Katrine, Winther, Tim, de Meij, Jan, Schwarz, Kaija-Leena, Kolho, Johanna C, Escher, Jiri, Bronsky

Publikováno v: Pediatric research.

Maintaining of remission early in the disease course of Crohn's disease (CD) is essential and has major impact on the future prognosis. This study aimed to identify baseline predictors to develop model allowing stratification of patients who will not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::95fdd440b86623da9fd7fcdc522ae706
https://pubmed.ncbi.nlm.nih.gov/36008595