Multi-omics analysis reveals drivers of loss of β-cell function after newly diagnosed autoimmune type 1 diabetes: An INNODIA‡multicenter study

Autor: Jose Juan Almagro Armenteros, Caroline Brorsson, Christian Holm Johansen, Karina Banasik, Gianluca Mazzoni, Robert Moulder, Karoliina Hirvonen, Tomi Suomi, Omid Rasool, Sylvaine FA Bruggraber, M Loredana Marcovecchio, Emile Hendricks, Naba Al-Sari, Ismo Mattila, Cristina Legido-Quigley, Tommi Suvitaival, Piotr J Chmura, Mikael Knip, Anke M Schulte, Jeong Heon Lee, Guido Sebastiani, Giuseppina Emanuela Grieco, Laura L Elo, Simranjeet Kaur, Flemming Pociot, Francesco Dotta, Tim Tree, Riitta Lahesmaa, Lut Overbergh, Chantal Mathieu, Mark Peakman, Søren Brunak

BackgroundHeterogeneity in the rate of β-cell loss in newly diagnosed type 1 diabetes patients is poorly understood and creates a barrier to designing and interpreting disease-modifying clinical trials. Integrative analyses of complementary multi-om

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1aed4945812f6d48199ab6c18d691d46
https://doi.org/10.1101/2023.03.22.23287261

CTLs are targeted to kill ? cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

Autor: Skowera A, Rj, Ellis, Varela-Calvi?o R, Arif S, Gc, Huang, Van-Krinks C, Zaremba A, Rackham C, Js, Allen, Tim, Tree, Zhao M, Colin Dayan, Ak, Sewell, Ww, Unger, Jw, Drijfhout, Ossendorp F, Bo, Roep, Peakman M

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7120ae633b53356fa01679840af7f3ab
http://europepmc.org/abstract/PMC/PMC2735904

Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans.

Autor: Hanna SJ; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom., Thayer TC; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.; Department of Biological and Chemical Sciences, Roberts Wesleyan University, Rochester, NY, United States., Robinson EJS; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom., Vinh NN; Division of Psychological Medicine and Clinical Neurosciences, Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom., Williams N; Division of Psychological Medicine and Clinical Neurosciences, Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom., Landry LG; Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver, CO, United States., Andrews R; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom., Siah QZ; John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, United Kingdom., Leete P; Department of Clinical and Biomedical Sciences, University of Exeter, Exeter, United Kingdom., Wyatt R; Department of Clinical and Biomedical Sciences, University of Exeter, Exeter, United Kingdom., McAteer MA; Department of Oncology, University of Oxford, Oxford, United Kingdom., Nakayama M; Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver, CO, United States., Wong FS; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom., Yang JHM; Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, Guy's Hospital, London, United Kingdom., Tree TIM; Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, Guy's Hospital, London, United Kingdom., Ludvigsson J; Division of Pediatrics, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences and Crown Princess Victoria Children´s Hospital, Linköping University, Linköping, Sweden., Dayan CM; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom., Tatovic D; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Oct 16; Vol. 14, pp. 1276255. Date of Electronic Publication: 2023 Oct 16 (Print Publication: 2023).

Low-dose IL-2 reduces IL-21 ⁺ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes.

Autor: Zhang JY; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Hamey F; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Trzupek D; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Mickunas M; Department of Immunobiology, King's College London, School of Immunology and Microbial Sciences, London, UK., Lee M; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Godfrey L; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Yang JHM; Department of Immunobiology, King's College London, School of Immunology and Microbial Sciences, London, UK., Pekalski ML; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Kennet J; Wellcome-MRC Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Biomedical Campus, Cambridge, UK., Waldron-Lynch F; Vertex Pharmaceuticals, Vertex Cell & Gene Therapies, Boston, MA, USA., Evans ML; Wellcome-MRC Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Biomedical Campus, Cambridge, UK., Tree TIM; Department of Immunobiology, King's College London, School of Immunology and Microbial Sciences, London, UK., Wicker LS; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Todd JA; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. john.todd@well.ox.ac.uk., Ferreira RC; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. ricardo.ferreira@well.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2022 Nov 28; Vol. 13 (1), pp. 7324. Date of Electronic Publication: 2022 Nov 28.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).

Autor: Cossarizza A; Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, Modena, Italy., Chang HD; German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany.; Institute for Biotechnology, Technische Universität, Berlin, Germany., Radbruch A; German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany., Abrignani S; Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi (INGM), Milan, Italy.; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy., Addo R; German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany., Akdis M; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland., Andrä I; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich, Germany., Andreata F; Division of Immunology, Transplantation and Infectious Diseases, IRCSS San Raffaele Scientific Institute, Milan, Italy., Annunziato F; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Arranz E; Mucosal Immunology Lab, Unidad de Excelencia Instituto de Biomedicina y Genética Molecular de Valladolid (IBGM, Universidad de Valladolid-CSIC), Valladolid, Spain., Bacher P; Institute of Immunology, Christian-Albrechts Universität zu Kiel & Universitätsklinik Schleswig-Holstein, Kiel, Germany.; Institute of Clinical Molecular Biology Christian-Albrechts Universität zu Kiel, Kiel, Germany., Bari S; Division of Medical Sciences, National Cancer Centre Singapore, Singapore.; Cancer & Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore., Barnaba V; Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy.; Center for Life Nano & Neuro Science@Sapienza, Istituto Italiano di Tecnologia (IIT), Rome, Italy.; Istituto Pasteur - Fondazione Cenci Bolognetti, Rome, Italy., Barros-Martins J; Institute of Immunology, Hannover Medical School, Hannover, Germany., Baumjohann D; Medical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology, University Hospital Bonn, University of Bonn, Bonn, Germany., Beccaria CG; Division of Immunology, Transplantation and Infectious Diseases, IRCSS San Raffaele Scientific Institute, Milan, Italy., Bernardo D; Mucosal Immunology Lab, Unidad de Excelencia Instituto de Biomedicina y Genética Molecular de Valladolid (IBGM, Universidad de Valladolid-CSIC), Valladolid, Spain.; Centro de Investigaciones Biomédicas en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain., Boardman DA; Department of Surgery, The University of British Columbia, Vancouver, Canada.; BC Children's Hospital Research Institute, Vancouver, Canada., Borger J; Department of Immunology and Pathology, Monash University, Melbourne, Victoria, Australia., Böttcher C; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Brockmann L; Department of Microbiology & Immunology, Columbia University, New York City, USA., Burns M; German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany., Busch DH; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich, Germany.; German Center for Infection Research (DZIF), Munich, Germany., Cameron G; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Parkville, Victoria, Australia., Cammarata I; Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy., Cassotta A; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Chang Y; Medical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology, University Hospital Bonn, University of Bonn, Bonn, Germany., Chirdo FG; Instituto de Estudios Inmunológicos y Fisiopatológicos - IIFP (UNLP-CONICET), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina., Christakou E; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, UK.; National Institute for Health Research (NIHR) Biomedical Research Center (BRC), Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK., Čičin-Šain L; Department of Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Cook L; BC Children's Hospital Research Institute, Vancouver, Canada.; Department of Medicine, The University of British Columbia, Vancouver, Canada., Corbett AJ; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Cornelis R; German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany., Cosmi L; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Davey MS; Infection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., De Biasi S; Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, Modena, Italy., De Simone G; Laboratory of Translational Immunology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Del Zotto G; IRCCS, Istituto Giannina Gaslini, Genova, Italy., Delacher M; Institute for Immunology, University Medical Center Mainz, Mainz, Germany.; Research Centre for Immunotherapy, University Medical Center Mainz, Mainz, Germany., Di Rosa F; Institute of Molecular Biology and Pathology, National Research Council of Italy (CNR), Rome, Italy.; Immunosurveillance Laboratory, The Francis Crick Institute, London, UK., Di Santo J; Innate Immunity Unit, Department of Immunology, Institut Pasteur, Paris, France.; Inserm U1223, Paris, France., Diefenbach A; Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.; Mucosal and Developmental Immunology, German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany., Dong J; Cell Biology, German Rheumatism Research Center Berlin (DRFZ), An Institute of the Leibniz Association, Berlin, Germany., Dörner T; German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany.; Department of Medicine/Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany., Dress RJ; Institute of Systems Immunology, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Dutertre CA; Institut National de la Sante Et de la Recherce Medicale (INSERM) U1015, Equipe Labellisee-Ligue Nationale contre le Cancer, Villejuif, France., Eckle SBG; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Eede P; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Evrard M; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Falk CS; Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany., Feuerer M; Regensburg Center for Interventional Immunology (RCI), Regensburg, Germany.; Chair for Immunology, University Regensburg, Regensburg, Germany., Fillatreau S; Institut Necker Enfants Malades, INSERM U1151-CNRS, UMR8253, Paris, France.; Université de Paris, Paris Descartes, Faculté de Médecine, Paris, France.; AP-HP, Hôpital Necker Enfants Malades, Paris, France., Fiz-Lopez A; Mucosal Immunology Lab, Unidad de Excelencia Instituto de Biomedicina y Genética Molecular de Valladolid (IBGM, Universidad de Valladolid-CSIC), Valladolid, Spain., Follo M; Department of Medicine I, Lighthouse Core Facility, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Foulds GA; John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.; Centre for Health, Ageing and Understanding Disease (CHAUD), School of Science and Technology, Nottingham Trent University, Nottingham, UK., Fröbel J; Immunology of Aging, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany., Gagliani N; Department of Medicine, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Germany., Galletti G; Laboratory of Translational Immunology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Gangaev A; Division of Molecular Oncology and Immunology, the Netherlands Cancer Institute, Amsterdam, The Netherlands., Garbi N; Institute of Molecular Medicine and Experimental Immunology, Faculty of Medicine, University of Bonn, Germany., Garrote JA; Mucosal Immunology Lab, Unidad de Excelencia Instituto de Biomedicina y Genética Molecular de Valladolid (IBGM, Universidad de Valladolid-CSIC), Valladolid, Spain.; Laboratory of Molecular Genetics, Servicio de Análisis Clínicos, Hospital Universitario Río Hortega, Gerencia Regional de Salud de Castilla y León (SACYL), Valladolid, Spain., Geginat J; Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi (INGM), Milan, Italy.; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy., Gherardin NA; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Parkville, Victoria, Australia., Gibellini L; Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, Modena, Italy., Ginhoux F; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore., Godfrey DI; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Parkville, Victoria, Australia., Gruarin P; Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi (INGM), Milan, Italy., Haftmann C; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Hansmann L; Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin (CVK), Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany.; German Cancer Consortium (DKTK), partner site Berlin, Germany., Harpur CM; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.; Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia., Hayday AC; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, UK.; National Institute for Health Research (NIHR) Biomedical Research Center (BRC), Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.; Immunosurveillance Laboratory, The Francis Crick Institute, London, UK., Heine G; Division of Allergy, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany., Hernández DC; Innate Immunity, German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Gastroenterology, Infectious Diseases, Rheumatology, Berlin, Germany., Herrmann M; Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Medicine 3 - Rheumatology and Immunology and Universitätsklinikum Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Hoelsken O; Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.; Mucosal and Developmental Immunology, German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany., Huang Q; Department of Surgery, The University of British Columbia, Vancouver, Canada.; BC Children's Hospital Research Institute, Vancouver, Canada., Huber S; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Huber JE; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany., Huehn J; Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Hundemer M; Department of Hematology, Oncology and Rheumatology, University Heidelberg, Heidelberg, Germany., Hwang WYK; Cancer & Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.; Department of Hematology, Singapore General Hospital, Singapore, Singapore.; Executive Offices, National Cancer Centre Singapore, Singapore., Iannacone M; Division of Immunology, Transplantation and Infectious Diseases, IRCSS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ivison SM; Department of Surgery, The University of British Columbia, Vancouver, Canada.; BC Children's Hospital Research Institute, Vancouver, Canada., Jäck HM; Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Department of Internal Medicine III, University of Erlangen-Nürnberg, Erlangen, Germany., Jani PK; German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany., Keller B; Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Kessler N; Institute of Molecular Medicine and Experimental Immunology, Faculty of Medicine, University of Bonn, Germany., Ketelaars S; Division of Molecular Oncology and Immunology, the Netherlands Cancer Institute, Amsterdam, The Netherlands., Knop L; Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg, Germany., Knopf J; Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Medicine 3 - Rheumatology and Immunology and Universitätsklinikum Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Koay HF; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Parkville, Victoria, Australia., Kobow K; Department of Neuropathology, Universitätsklinikum Erlangen, Germany., Kriegsmann K; Department of Hematology, Oncology and Rheumatology, University Heidelberg, Heidelberg, Germany., Kristyanto H; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Krueger A; Institute for Molecular Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany., Kuehne JF; Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany., Kunze-Schumacher H; Institute for Molecular Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany., Kvistborg P; Division of Molecular Oncology and Immunology, the Netherlands Cancer Institute, Amsterdam, The Netherlands., Kwok I; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Latorre D; Institute of Microbiology, ETH Zurich, Zurich, Switzerland., Lenz D; German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany., Levings MK; Department of Surgery, The University of British Columbia, Vancouver, Canada.; BC Children's Hospital Research Institute, Vancouver, Canada.; School of Biomedical Engineering, The University of British Columbia, Vancouver, Canada., Lino AC; German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany., Liotta F; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Long HM; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Lugli E; Laboratory of Translational Immunology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., MacDonald KN; BC Children's Hospital Research Institute, Vancouver, Canada.; School of Biomedical Engineering, The University of British Columbia, Vancouver, Canada.; Michael Smith Laboratories, The University of British Columbia, Vancouver, Canada., Maggi L; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Maini MK; Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London, London, UK., Mair F; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Manta C; Department of Hematology, Oncology and Rheumatology, University Heidelberg, Heidelberg, Germany., Manz RA; Institute for Systemic Inflammation Research, University of Luebeck, Luebeck, Germany., Mashreghi MF; German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany., Mazzoni A; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., McCluskey J; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Mei HE; German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany., Melchers F; German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany., Melzer S; Clinical Trial Center Leipzig, Leipzig University, Härtelstr.16, -18, Leipzig, 04107, Germany., Mielenz D; Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Department of Internal Medicine III, University of Erlangen-Nürnberg, Erlangen, Germany., Monin L; Immunosurveillance Laboratory, The Francis Crick Institute, London, UK., Moretta L; Department of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy., Multhoff G; Radiation Immuno-Oncology Group, Center for Translational Cancer Research (TranslaTUM), Technical University of Munich (TUM), Klinikum rechts der Isar, Munich, Germany.; Department of Radiation Oncology, Technical University of Munich (TUM), Klinikum rechts der Isar, Munich, Germany., Muñoz LE; Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Medicine 3 - Rheumatology and Immunology and Universitätsklinikum Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Muñoz-Ruiz M; Immunosurveillance Laboratory, The Francis Crick Institute, London, UK., Muscate F; Department of Medicine, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Natalini A; Institute of Molecular Biology and Pathology, National Research Council of Italy (CNR), Rome, Italy., Neumann K; Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ng LG; Division of Medical Sciences, National Cancer Centre Singapore, Singapore.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.; Department of Microbiology & Immunology, Immunology Programme, Life Science Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Niedobitek A; German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany., Niemz J; Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Almeida LN; Institute for Systemic Inflammation Research, University of Luebeck, Luebeck, Germany., Notarbartolo S; Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi (INGM), Milan, Italy., Ostendorf L; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Pallett LJ; Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London, London, UK., Patel AA; Institut National de la Sante Et de la Recherce Medicale (INSERM) U1015, Equipe Labellisee-Ligue Nationale contre le Cancer, Villejuif, France., Percin GI; Immunology of Aging, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany., Peruzzi G; Center for Life Nano & Neuro Science@Sapienza, Istituto Italiano di Tecnologia (IIT), Rome, Italy., Pinti M; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Pockley AG; John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.; Centre for Health, Ageing and Understanding Disease (CHAUD), School of Science and Technology, Nottingham Trent University, Nottingham, UK., Pracht K; Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Department of Internal Medicine III, University of Erlangen-Nürnberg, Erlangen, Germany., Prinz I; Institute of Immunology, Hannover Medical School, Hannover, Germany.; Institute of Systems Immunology, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Pujol-Autonell I; National Institute for Health Research (NIHR) Biomedical Research Center (BRC), Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.; Peter Gorer Department of Immunobiology, King's College London, London, UK., Pulvirenti N; Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi (INGM), Milan, Italy., Quatrini L; Department of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy., Quinn KM; School of Biomedical and Health Sciences, RMIT University, Bundorra, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia., Radbruch H; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Rhys H; Flow Cytometry Science Technology Platform, The Francis Crick Institute, London, UK., Rodrigo MB; Institute of Molecular Medicine and Experimental Immunology, Faculty of Medicine, University of Bonn, Germany., Romagnani C; Innate Immunity, German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Gastroenterology, Infectious Diseases, Rheumatology, Berlin, Germany., Saggau C; Institute of Immunology, Christian-Albrechts Universität zu Kiel & Universitätsklinik Schleswig-Holstein, Kiel, Germany., Sakaguchi S; Immunology Frontier Research Center, Osaka University, Japan., Sallusto F; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.; Institute of Microbiology, ETH Zurich, Zurich, Switzerland., Sanderink L; Regensburg Center for Interventional Immunology (RCI), Regensburg, Germany.; Chair for Immunology, University Regensburg, Regensburg, Germany., Sandrock I; Institute of Immunology, Hannover Medical School, Hannover, Germany., Schauer C; Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Medicine 3 - Rheumatology and Immunology and Universitätsklinikum Erlangen, Erlangen, Germany.; 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Publikováno v: European journal of immunology [Eur J Immunol] 2021 Dec; Vol. 51 (12), pp. 2708-3145. Date of Electronic Publication: 2021 Dec 07.