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Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs

Autor: Erich W. Zinser, William Howson, Tom L. McTier, Tim Stuk, Goodwin Richard M, Patrick F.M. Meeus, Michael P. Curtis, Jason Koch, Jeffrey Ellis Price, Vaillancourt Valerie A, Sanjay Menon, Aleah Pullins, Debra J. Woods, Nathan Anthony Logan Chubb, Laura Hedges

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 26:1831-1835

Over the last decade, the isoxazoline motif has become the intense focus of crop protection and animal health companies in their search for novel pesticides and ectoparasiticides. Herein we report the discovery of sarolaner, a proprietary, optimized-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860dc9ac80dda49d88ef5693e01c4884
https://doi.org/10.1016/j.bmcl.2016.02.027

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The discovery of isoxazoline oxime ethers as a new class of ectoparasiticides for the control of Haematobia irritans (horn fly) in cattle

Autor: Aleah Pullins, Edmund L. Ellsworth, Michael P. Curtis, Goodwin Richard M, Kent Mills, Tom L. McTier, Sanjay Menon, Jason Koch, Nathan Anthony Logan Chubb, Erich W. Zinser, Sue Holzmer, Tim Stuk

Publikováno v: Bioorganicmedicinal chemistry letters. 24(21)

Haematobia irritans (horn fly) infestation in cattle is responsible for over a billion dollars a year in global economic loss due to decreased milk production and lower feed conversion. There is significant need for new insecticidal agents since curr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a00669bfe37ab05c481d1b390780cd
https://pubmed.ncbi.nlm.nih.gov/25278232

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