Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Tim S. Whittingham"'
Publikováno v:
Metabolic Brain Disease. 10:347-352
In vivo localized nuclear magnetic resonance spectroscopy has shown three-fold higher phosphocreatine/nucleoside triphosphate (PCr/NTP) ratios in cerebral white compared to gray matter. To interpret these results, total creatine (Cr) and ATP concentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4123a64f908860abb276bbc010e5342
https://doi.org/10.1007/bf02109364
https://doi.org/10.1007/bf02109364
Autor:
Anthony J. Ricci, H. M. Assaf, W. D. Lust, Tim S. Whittingham, Joseph C. LaManna, Robert A. Ratcheson
Publikováno v:
Metabolic Brain Disease. 5:143-154
Lactic acid accumulation has been implicated in the evolution of brain damage after ischemia. Since compartmentation of lactate may play a role in acid-base balance, lactate release from gerbil hippocampal slices was examined during a number of metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa42a1748a889cefb6f1a7430ea4197
https://doi.org/10.1007/bf00999841
https://doi.org/10.1007/bf00999841
Publikováno v:
Respiration physiology. 115(1)
We characterized the electrophysiological properties and responses of neurons located in the parapyramidal region of the ventral aspect of the rat medulla oblongata (parapyramidal neurons, PP neurons) to oxygen deprivation, in order to understand the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30990c1dae0383c3396abb6d3156feca
https://pubmed.ncbi.nlm.nih.gov/10344411
https://pubmed.ncbi.nlm.nih.gov/10344411
Autor:
W. David Lust, Tim S. Whittingham, Bryan K. Yamamoto, Albertina J. Douglas, Stacy E. Stephans
Publikováno v:
Journal of neurochemistry. 71(2)
High doses of methamphetamine (METH) produce a long-term depletion in striatal tissue dopamine content. The mechanism mediating this toxicity has been associated with increased concentrations of dopamine and glutamate and altered energy metabolism. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e9ef04bbc298ea2968225deeb97743
https://pubmed.ncbi.nlm.nih.gov/9681451
https://pubmed.ncbi.nlm.nih.gov/9681451
Publikováno v:
Mechanisms of ageing and development. 89(2)
Myocardial injury following ischemia and reperfusion is increased in the aging heart. The mechanisms underlying the increased susceptibility of the aging heart to ischemic injury remain unknown. We investigated whether decreased glycogen utilization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bacef0164e4c8be7803d642cb7fc58bc
https://pubmed.ncbi.nlm.nih.gov/8844644
https://pubmed.ncbi.nlm.nih.gov/8844644
Publikováno v:
Journal of the American College of Cardiology. 25(2)
Myocardial injury following ischemia and reperfusion is increased in the aging heart, including in the aging 24 mo Fischer 344 rat (mean survival 29 mo) compared to the Fischer 344 adult (6 mo). Adenosine (ADO) has been increasingly appreciated as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1045fae73160455c7fce66aa16ce2c64
Autor:
Robert A. Ratcheson, W. D. Lust, Joseph C. LaManna, Tim S. Whittingham, Svetlana Pundik, Warren R. Selman, Hoffman Tl
Publikováno v:
Journal of neurosurgery. 81(4)
✓ Tissue acidosis is believed to be a key element in ischemic injury of neural tissue. The goal of this study was to determine whether persisting postischemic acidosis or the extent of acidosis would affect metabolic recovery following an ischemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11380b00ee5089cb0c1a065e92c2c69a
https://pubmed.ncbi.nlm.nih.gov/7931590
https://pubmed.ncbi.nlm.nih.gov/7931590
Publikováno v:
Metabolic brain disease. 7(2)
The introduction of exogenous glutamate to normally respiring hippocampal slices produced substantial reductions in ATP, phosphocreatine (PCr) and intracellular pH (pHi) when the concentration exceeded 1 mM. These changes were not prevented by additi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda18a68290c3ebf76fa163128590f47
https://pubmed.ncbi.nlm.nih.gov/1356225
https://pubmed.ncbi.nlm.nih.gov/1356225