Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Tim S. Heistek"'
Autor:
Eline J. Mertens, Yoni Leibner, Jean Pie, Anna A. Galakhova, Femke Waleboer, Julia Meijer, Tim S. Heistek, René Wilbers, Djai Heyer, Natalia A. Goriounova, Sander Idema, Matthijs B. Verhoog, Brian E. Kalmbach, Brian R. Lee, Ryder P. Gwinn, Ed S. Lein, Eleonora Aronica, Jonathan Ting, Huibert D. Mansvelder, Idan Segev, Christiaan P.J. de Kock
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114100- (2024)
Summary: Hippocampal pyramidal neuron activity underlies episodic memory and spatial navigation. Although extensively studied in rodents, extremely little is known about human hippocampal pyramidal neurons, even though the human hippocampus underwent
Externí odkaz:
https://doaj.org/article/371ff7956af64d3bbda89f13ea9ec965
Autor:
Stan L. W. Driessens, Anna A. Galakhova, Djai B. Heyer, Isabel J. Pieterse, René Wilbers, Eline J. Mertens, Femke Waleboer, Tim S. Heistek, Loet Coenen, Julia R. Meijer, Sander Idema, Philip C. de Witt Hamer, David P. Noske, Christiaan P. J. de Kock, Brian R. Lee, Kimberly Smith, Jonathan T. Ting, Ed S. Lein, Huibert D. Mansvelder, Natalia A. Goriounova
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract GWAS have identified numerous genes associated with human cognition but their cell type expression profiles in the human brain are unknown. These genes overlap with human accelerated regions (HARs) implicated in human brain evolution and mig
Externí odkaz:
https://doaj.org/article/50832097a77b45fca91162348467e082
Autor:
Sybren F. de Kloet, Bastiaan Bruinsma, Huub Terra, Tim S. Heistek, Emma M. J. Passchier, Alexandra R. van den Berg, Antonio Luchicchi, Rogier Min, Tommy Pattij, Huibert D. Mansvelder
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
This study presents an anatomical, neurophysiological and functional characterization of four distinct prefrontal populations that project to striatal and thalamic sub-regions. The authors show that each of these populations have a discrete role in t
Externí odkaz:
https://doaj.org/article/17bef0b137494ed7848e3fdce6586f9f
Autor:
Joshua Obermayer, Antonio Luchicchi, Tim S. Heistek, Sybren F. de Kloet, Huub Terra, Bastiaan Bruinsma, Ouissame Mnie-Filali, Christian Kortleven, Anna A. Galakhova, Ayoub J. Khalil, Tim Kroon, Allert J. Jonker, Roel de Haan, Wilma D. J. van de Berg, Natalia A. Goriounova, Christiaan P. J. de Kock, Tommy Pattij, Huibert D. Mansvelder
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
VIP interneurons have been shown to disinhibit pyramidal neurons by inhibiting other interneuron types. Here, the authors report that ChAT-VIP subtype of interneurons directly excite pyramidal neurons in multiple layers via fast cholinergic neurotran
Externí odkaz:
https://doaj.org/article/59339fd0ec524e8d8a59a8fece53b4cb
Autor:
Sara Hijazi, Tim S. Heistek, Rolinka van der Loo, Huibert D. Mansvelder, August B. Smit, Ronald E. van Kesteren
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101271- (2020)
Summary: Parvalbumin (PV) interneuron dysfunction is associated with various brain disorders, including Alzheimer disease (AD). Here, we asked whether early PV neuron hyperexcitability primes the hippocampus for amyloid beta-induced functional impair
Externí odkaz:
https://doaj.org/article/fa1b308823a54f35a4babee6a6085298
Autor:
Ioannis Kramvis, Rhodé van Westen, Hanna C. A. Lammertse, Danai Riga, Tim S. Heistek, Alex Loebel, Sabine Spijker, Huibert D. Mansvelder, Rhiannon M. Meredith
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Changes in excitation and inhibition are associated with the pathobiology of neurodevelopmental disorders of intellectual disability and autism and are widely described in Fragile X syndrome (FXS). In the prefrontal cortex (PFC), essential for cognit
Externí odkaz:
https://doaj.org/article/693380dca7b24a30a1210680191262f2
Autor:
Joshua Obermayer, Tim S. Heistek, Amber Kerkhofs, Natalia A. Goriounova, Tim Kroon, Johannes C. Baayen, Sander Idema, Guilherme Testa-Silva, Jonathan J. Couey, Huibert D. Mansvelder
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Parvalbumin and somatostatin expressing interneurons mediate lateral inhibition between cortical neurons. Here the authors report the mechanisms by which acetylcholine from the basal forebrain selectively augments lateral inhibition via Martinotti ce
Externí odkaz:
https://doaj.org/article/3bb32f558e4e41c8984accb0680d2e97
Autor:
Joshua Obermayer, Antonio Luchicchi, Tim S. Heistek, Sybren F. de Kloet, Huub Terra, Bastiaan Bruinsma, Ouissame Mnie-Filali, Christian Kortleven, Anna A. Galakhova, Ayoub J. Khalil, Tim Kroon, Allert J. Jonker, Roel de Haan, Wilma D. J. van de Berg, Natalia A. Goriounova, Christiaan P. J. de Kock, Tommy Pattij, Huibert D. Mansvelder
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/a04239147e064305a9366bd3092f352a
Autor:
Amber Kerkhofs, Paula M. Canas, A. J. Timmerman, Tim S. Heistek, Joana I. Real, Carolina Xavier, Rodrigo A. Cunha, Huibert D. Mansvelder, Samira G. Ferreira
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Adenosine A2A receptors (A2AR) are activated upon increased synaptic activity to assist in the implementation of long-term plastic changes at synapses. While it is reported that A2AR are involved in the control of prefrontal cortex (PFC)-dependent be
Externí odkaz:
https://doaj.org/article/05b9790f4b364efc82b54a249c0a958c
Autor:
Mandy S. J. Kater, Katharina F. Baumgart, Aina Badia‐Soteras, Tim S. Heistek, Karen E. Carney, A. Jacob Timmerman, Jan R. T. van Weering, August B. Smit, Marjo S. van der Knaap, Huibert D. Mansvelder, Mark H. G. Verheijen, Rogier Min
Publikováno v:
Kater, M S J, Baumgart, K F, Badia-Soteras, A, Heistek, T S, Carney, K E, Timmerman, A J, van Weering, J R T, Smit, A B, van der Knaap, M S, Mansvelder, H D, Verheijen, M H G & Min, R 2023, ' A novel role for MLC1 in regulating astrocyte–synapse interactions ', GLIA, vol. 71, no. 7, pp. 1770-1785 . https://doi.org/10.1002/glia.24368
Glia, 71(7), 1770-1785. John Wiley and Sons Inc.
GLIA, 71(7), 1770-1785. John Wiley and Sons Inc.
Kater, M S J, Baumgart, K F, Badia-Soteras, A, Heistek, T S, Carney, K E, Timmerman, A J, van Weering, J R T, Smit, A B, van der Knaap, M S, Mansvelder, H D, Verheijen, M H G & Min, R 2023, ' A novel role for MLC1 in regulating astrocyte–synapse interactions ', Glia, vol. 71, no. 7, pp. 1770-1785 . https://doi.org/10.1002/glia.24368
Glia, 71(7), 1770-1785. John Wiley and Sons Inc.
GLIA, 71(7), 1770-1785. John Wiley and Sons Inc.
Kater, M S J, Baumgart, K F, Badia-Soteras, A, Heistek, T S, Carney, K E, Timmerman, A J, van Weering, J R T, Smit, A B, van der Knaap, M S, Mansvelder, H D, Verheijen, M H G & Min, R 2023, ' A novel role for MLC1 in regulating astrocyte–synapse interactions ', Glia, vol. 71, no. 7, pp. 1770-1785 . https://doi.org/10.1002/glia.24368
Loss of function of the astrocyte membrane protein MLC1 is the primary genetic cause of the rare white matter disease Megalencephalic Leukoencephalopathy with subcortical Cysts (MLC), which is characterized by disrupted brain ion and water homeostasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33cbe10cd35672d6014c75fbbae2d06
https://research.vumc.nl/en/publications/4a3453d2-881d-4b24-bf30-c4e9ae534160
https://research.vumc.nl/en/publications/4a3453d2-881d-4b24-bf30-c4e9ae534160
