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Akademický článek

A Proteomics and Transcriptomics Investigation of the Venom from the Barychelid Spider Trittame loki (Brush-Foot Trapdoor)

Autor: Eivind A. B. Undheim, Kartik Sunagar, Volker Herzig, Laurence Kely, Dolyce H. W. Low, Timothy N. W. Jackson, Alun Jones, Nyoman Kurniawan, Glenn F. King, Syed A. Ali, Agostino Antunes, Tim Ruder, Bryan G. Fry

Publikováno v: Toxins, Vol 5, Iss 12, Pp 2488-2503 (2013)

Although known for their potent venom and ability to prey upon both invertebrate and vertebrate species, the Barychelidae spider family has been entirely neglected by toxinologists. In striking contrast, the sister family Theraphosidae (commonly know

Externí odkaz: https://doaj.org/article/5fcbda661d854c52943cc79d56a0a178

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Development of anti-PEG bispecific antibodies for targeting PEGylated nanoparticles to tumour cells

Autor: Tim Ruder

Cancer treatment is significantly impaired by the low therapeutic index traditionally exhibited by most current chemotherapeutics. This is principally a result of a ubiquitous systemic distribution of these drugs. Recent advances in chemotherapy have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ca3d31b1a56c57a08e55ea35c5e900d
https://doi.org/10.14264/uql.2017.655

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A Proteomics and Transcriptomics Investigation of the Venom from the Barychelid Spider Trittame loki (Brush-Foot Trapdoor)

Autor: Laurence Kely, Eivind A. B. Undheim, Tim Ruder, Alun Jones, Glenn F. King, Dolyce H.W. Low, Bryan G. Fry, Syed Abid Ali, Nyoman D. Kurniawan, Agostino Antunes, Kartik Sunagar, Timothy N.W. Jackson, Volker Herzig

Publikováno v: Toxins
Toxins; Volume 5; Issue 12; Pages: 2488-2503
Toxins, Vol 5, Iss 12, Pp 2488-2503 (2013)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed0f5158c9242b10829ff860fb66e16
https://doi.org/10.3390/toxins5122488

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Dracula's children: Molecular evolution of vampire bat venom

Autor: Glenn F. King, Sandy Pineda Gonzalez, Kartik Sunagar, Dolyce H.W. Low, Syed Abid Ali, Bryan G. Fry, Alejandro Alagón, Eivind A. B. Undheim, Agostinho Antunes, Alun Jones, Tim Ruder, Timothy N.W. Jackson

Publikováno v: Journal of Proteomics. 89:95-111

While vampire bat oral secretions have been the subject of intense research, efforts have concentrated only on two components: DSPA (Desmodus rotundus salivary plasminogen activator) and Draculin. The molecular evolutionary history of DSPA has been e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb380b80ba2e52fa400c55a2a4e42ab
https://doi.org/10.1016/j.jprot.2013.05.034

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Molecular Phylogeny and Evolution of the Proteins Encoded by Coleoid (Cuttlefish, Octopus, and Squid) Posterior Venom Glands

Autor: Kartik Sunagar, Timothy N.W. Jackson, Syed Abid Ali, Agostinho Antunes, Dolyce H.W. Low, Eivind A. B. Undheim, Tak-Cheung Wai, Bryan G. Fry, Glenn F. King, Tim Ruder

Publikováno v: Journal of Molecular Evolution

In this study, we report for the first time a detailed evaluation of the phylogenetic history and molecular evolution of the major coleoid toxins: CAP, carboxypeptidase, chitinase, metalloprotease GON-domain, hyaluronidase, pacifastin, PLA2, SE-cepha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19fe64295ee19ba7f0148694ac1652f
https://doi.org/10.1007/s00239-013-9552-5

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Structural and Molecular Diversification of the Anguimorpha Lizard Mandibular Venom Gland System in the Arboreal Species Abronia graminea

Autor: Glenn F. King, Darryl L. Whitehead, Alejandro Alagón, Alejandro Carbajal Saucedo, Eivind A. B. Undheim, Kartik Sunagar, Ivan Koludarov, Bryan G. Fry, Tim Ruder, Timothy N.W. Jackson, Agostinho Antunes, G. Roberto Mora

Publikováno v: Journal of Molecular Evolution. 75:168-183

In the past, toxinological research on reptiles has focused principally on clinically important species. As a result, our understanding of the evolution of the reptile venom system is limited. Here, for the first time, we describe the structural and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0f81321ea006e6d551e0bc2f9e2df6
https://doi.org/10.1007/s00239-012-9529-9

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Functional characterization on invertebrate and vertebrate tissues of tachykinin peptides from octopus venoms

Autor: Kiel G. Ormerod, Tim Ruder, Paul F. Alewood, Sabatino Ventura, Glenn F. King, Andreas Brust, Bryan G. Fry, Timothy N.W. Jackson, A. Joffre Mercier, Syed Abid Ali, Mary-Louise Roymanchadi, Eivind A. B. Undheim

Publikováno v: Peptides. 47

It has been previously shown that octopus venoms contain novel tachykinin peptides that despite being isolated from an invertebrate, contain the motifs characteristic of vertebrate tachykinin peptides rather than being more like conventional inverteb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f97822bdfbe72fd04f4ec09dbe5fd9
https://pubmed.ncbi.nlm.nih.gov/23850991

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Venom proteomic characterization and relative antivenom neutralization of two medically important Pakistani elapid snakes (Bungarus sindanus and Naja naja)

Autor: Daryl C. Yang, Wayne C. Hodgson, Kelly Wood, Sean McCarthy, Timothy N.W. Jackson, Tim Ruder, Ivan Koludarov, Alun Jones, Syed Abid Ali, Bryan G. Fry, Elvind A B Undheim

Publikováno v: Journal of proteomics. 89

Intra- and interspecific variation in venom composition has been shown to have a major effect upon the efficacy of antivenoms. Due to the absence of domestically produced antivenoms, Pakistan is wholly reliant upon antivenoms produced in other countr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398bfe91555240d4025d71bd6c2c691b
https://pubmed.ncbi.nlm.nih.gov/23714137

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