Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Tim R. Blower"'
Autor:
Tom J. Arrowsmith, Xibing Xu, Shangze Xu, Ben Usher, Peter Stokes, Megan Guest, Agnieszka K. Bronowska, Pierre Genevaux, Tim R. Blower
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Nucleotidyltransferases (NTases) control diverse physiological processes, including RNA modification, DNA replication and repair, and antibiotic resistance. The Mycobacterium tuberculosis NTase toxin family, MenT, modifies tRNAs to block tra
Externí odkaz:
https://doaj.org/article/0b8cfa70586a40899ff0c0d5f6b0b175
Autor:
Sam C. Went, David M. Picton, Richard D. Morgan, Andrew Nelson, Aisling Brady, Giuseppina Mariano, David T. F. Dryden, Darren L. Smith, Nicolas Wenner, Jay C. D. Hinton, Tim R. Blower
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Bacteria have evolved a broad range of systems that provide defence against their viral predators, bacteriophages. Bacteriophage Exclusion (BREX) systems recognise and methylate 6 bp non-palindromic motifs within the host genome, and prevent
Externí odkaz:
https://doaj.org/article/f9d96556945641aca3006a94eb0b5cec
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background Despite Spirochetales being a ubiquitous and medically important order of bacteria infecting both humans and animals, there is extremely limited information regarding their bacteriophages. Of the genus Treponema, there is just a s
Externí odkaz:
https://doaj.org/article/8e27edd0458f4c50a275d1cf68e7669c
Autor:
Xibing Xu, Ben Usher, Claude Gutierrez, Roland Barriot, Tom J. Arrowsmith, Xue Han, Peter Redder, Olivier Neyrolles, Tim R. Blower, Pierre Genevaux
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Mycobacterium tuberculosis, the bacterium responsible for human tuberculosis, has a genome encoding a remarkably high number of toxin-antitoxin systems of largely unknown function. We have recently shown that the M. tuberculosis genome encod
Externí odkaz:
https://doaj.org/article/192b7c0f9cc2492486b0eb24b655df5a
Autor:
Alejandra Guillén-García, Savannah E. R. Gibson, Caleb J. C. Jordan, Venkata K. Ramaswamy, Victoria L. Linthwaite, Elizabeth H. C. Bromley, Adrian P. Brown, David R. W. Hodgson, Tim R. Blower, Jan R. R. Verlet, Matteo T. Degiacomi, Lars-Olof Pålsson, Martin J. Cann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The transfer of electronic energy through a photosystem can harm the photosynthetic apparatus when not balanced with CO2 fixation. Here, the authors show that CO2 modulates electronic energy transfer in cyanobacteria by binding to and enhancing the a
Externí odkaz:
https://doaj.org/article/29c36c67df1547bd98af571796e98e1b
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 211-219 (2022)
Bacteria are constantly challenged by bacteriophage (phage) infection and have developed multitudinous and varied resistance mechanisms. Bacteriophage Exclusion (BREX) systems protect from phage infection by generating methylation patterns at non-pal
Externí odkaz:
https://doaj.org/article/6788e7788eb84c889b59786e70d0b39a
Autor:
Ella V. Rodwell, Nicolas Wenner, Caisey V. Pulford, Yueyi Cai, Arthur Bowers-Barnard, Alison Beckett, Jonathan Rigby, David M. Picton, Tim R. Blower, Nicholas A. Feasey, Jay C. D. Hinton, Blanca M. Perez-Sepulveda
Publikováno v:
Viruses, Vol 13, Iss 3, p 478 (2021)
In recent years, novel lineages of invasive non-typhoidal Salmonella (iNTS) serovars Typhimurium and Enteritidis have been identified in patients with bloodstream infection in Sub-Saharan Africa. Here, we isolated and characterised 32 phages capable
Externí odkaz:
https://doaj.org/article/d61a794ea1774f13aafdd756e2cb167e
Autor:
Jasmine M. Cross, Tim R. Blower, Alexander D. H. Kingdon, Robert Pal, David M. Picton, James W. Walton
Publikováno v:
Molecules, Vol 25, Iss 10, p 2383 (2020)
The histone deacetylase (HDAC) enzymes have emerged as an important class of molecular targets in cancer therapy, with five inhibitors in clinical use. Recently, it has been shown that a lack of selectivity between the 11 Zn-dependent HDAC isoforms m
Externí odkaz:
https://doaj.org/article/6ca263e9df1147debc04b2066e7b6e4a
Autor:
David M. Picton, Joshua D. Harling-Lee, Samuel J. Duffner, Sam C. Went, Richard D. Morgan, Jay C. D. Hinton, Tim R. Blower
Publikováno v:
Nucleic Acids Research, 2022, Vol.50(9), pp.5191-5207 [Peer Reviewed Journal]
Picton, D M, Harling-Lee, J D, Duffner, S J, Went, S C, Morgan, R D, Hinton, J C D & Blower, T R 2022, ' A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands ', Nucleic Acids Research, vol. 50, no. 9, pp. 5191-5207 . https://doi.org/10.1093/nar/gkac334
Picton, D M, Harling-Lee, J D, Duffner, S J, Went, S C, Morgan, R D, Hinton, J C D & Blower, T R 2022, ' A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands ', Nucleic Acids Research, vol. 50, no. 9, pp. 5191-5207 . https://doi.org/10.1093/nar/gkac334
Bacteria are under constant assault by bacteriophages and other mobile genetic elements. As a result, bacteria have evolved a multitude of systems that protect from attack. Genes encoding bacterial defence mechanisms can be clustered into “defence
Autor:
Giuseppina Mariano, Tim R. Blower
Publikováno v:
Molecular Microbiology, 2023 [Peer Reviewed Journal]
Bacteria are continuously exposed to predation from bacteriophages (phages) and, in response, have evolved a broad range of defence systems. These systems can prevent the replication of phages and other mobile genetic elements (MGE). Defence systems