Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Tim Philipp Simon"'
Autor:
Michael Bauer, MD, Andreas Weyland, MD, Gernot Marx, MD, Frank Bloos, MD, PhD, Stephan Weber, Dipl. Stat., Norbert Weiler, MD, Stefan Kluge, MD, Anja Diers, MD, Tim Philipp Simon, MD, Ingmar Lautenschläger, MD, Matthias Gründling, MD, Ulrich Jaschinski, MD, Philipp Simon, MD, Axel Nierhaus, MD, Onnen Moerer, MD, Lorenz Reill, MD, Achim Jörres, MD, Renfeng Guo, MD, Markus Loeffler, MD, Konrad Reinhart, MD, Niels Riedemann, MD, for the SepNet-Study Group
Publikováno v:
Critical Care Explorations, Vol 3, Iss 11, p e0577 (2021)
IMPORTANCE:. Anaphylatoxin C5a, a proinflammatory complement split product, plays a central role in mediating organ dysfunction. OBJECTIVES:. This phase II clinical trial was conducted to study safety, tolerability, pharmacokinetics, and pharmacodyna
Externí odkaz:
https://doaj.org/article/425409c1c667424ab3c5530f15b92a63
Autor:
Carolina Neu, Christian Beckers, Nadine Frank, Katharina Thomas, Matthias Bartneck, Tim-Philipp Simon, Jana Mossanen, Kimmo Peters, Tobias Singendonk, Lukas Martin, Gernot Marx, Sandra Kraemer, Elisabeth Zechendorf
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Sepsis, marked by organ dysfunction, necessitates reliable biomarkers. Ribonuclease inhibitor 1 (RNH1), a ribonuclease (RNase) inhibitor, emerged as a potential biomarker for acute kidney injury and mortality in thoracoabdominal aortic aneur
Externí odkaz:
https://doaj.org/article/74d1435f19a343e8bdda8367b314c237
Autor:
Matthias Manfred Deininger, Stefan Schnitzler, Carina Benstoem, Tim-Philipp Simon, Gernot Marx, Despina Panagiotidis, Dmitrij Ziles, Heike Schnoering, Evangelos Karasimos, Thomas Breuer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Cardiac surgery patients not only undergo a highly invasive procedure but are at risk for a diversity of postoperative complications. Up to 53% of these patients suffer from postoperative delirium (POD). This severe and common adverse event
Externí odkaz:
https://doaj.org/article/d59e72a8e0ee400fbe9d149158837585
Autor:
Felix Marius Bläsius, Johannes Greven, Weijun Guo, Eftychios Bolierakis, Zhizhen He, Cavan Lübke, Tim-Philipp Simon, Frank Hildebrand, Klemens Horst
Publikováno v:
European Journal of Medical Research, Vol 28, Iss 1, Pp 1-10 (2023)
Abstract Little is known about the impact of multiple trauma (MT)-related systemic hypoxia on osseous protein concentration of the hypoxia transcriptome. To shed light on this issue, we investigated erythropoietin (Epo), erythropoietin receptor (EpoR
Externí odkaz:
https://doaj.org/article/9a6925dde0a0475495cf59f2fc09ddf5
Autor:
Elisabeth Zechendorf, Christian Beckers, Nadine Frank, Sandra Kraemer, Carolina Neu, Thomas Breuer, Michael Dreher, Edgar Dahl, Gernot Marx, Lukas Martin, Tim-Philipp Simon
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12428 (2023)
The COVID-19 pandemic caused by the new SARS-CoV-2 coronavirus is the most recent and well-known outbreak of a coronavirus. RNase 1 is a small endogenous antimicrobial polypeptide that possesses antiviral activity against viral diseases. In this stud
Externí odkaz:
https://doaj.org/article/c20d7b52d69d4d129c1a18ff6be5cfe8
Autor:
Aileen Hill, Deborah Bergmann, Janin Schulte, Rashad Zayat, Gernot Marx, Tim-Philipp Simon, Jana Mossanen, Anne Brücken, Christian Stoppe
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2023)
IntroductionVarious clinical scores have been developed to predict organ dysfunction and mortality in patients undergoing cardiac surgery, but outcome prediction may be inaccurate for some patient groups. Proenkephalin A (penKid) and bioactive adreno
Externí odkaz:
https://doaj.org/article/5b1299e78cb3450d8435973ba71269c1
Autor:
Gernot Marx, Kai Zacharowski, Carole Ichai, Karim Asehnoune, Vladimír Černý, Rolf Dembinski, Ricard Ferrer Roca, Dietmar Fries, Zsolt Molnar, Peter Rosenberger, Manuel Sanchez-Sanchez, Tobias Schürholz, Tamara Dehnhardt, Sonja Schmier, Elke von Kleist, Ute Brauer, Tim-Philipp Simon
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background Sepsis is associated with capillary leakage and vasodilatation and leads to hypotension and tissue hypoperfusion. Early plasma volume replacement is required to achieve haemodynamic stability (HDS) and maintain adequate tissue oxy
Externí odkaz:
https://doaj.org/article/21bafa4b560c4e08966d7a067c3be7a5
Autor:
Elisabeth Zechendorf, Phillip Vaßen, Jieyi Zhang, Ahmed Hallawa, Antons Martincuks, Oliver Krenkel, Gerhard Müller-Newen, Tobias Schuerholz, Tim-Philipp Simon, Gernot Marx, Gerd Ascheid, Anke Schmeink, Guido Dartmann, Christoph Thiemermann, Lukas Martin
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/f6c3bedf98c8412d9e1389267c2bb0b4
Autor:
Christian Bleilevens, Josefin Soppert, Adrian Hoffmann, Thomas Breuer, Jürgen Bernhagen, Lukas Martin, Lara Stiehler, Gernot Marx, Michael Dreher, Christian Stoppe, Tim-Philipp Simon
Publikováno v:
Diagnostics, Vol 11, Iss 2, p 332 (2021)
Mortality in critically ill coronavirus disease 2019 (COVID-19) patients is high and pharmacological treatment strategies remain limited. Early-stage predictive biomarkers are needed to identify patients with a high risk of severe clinical courses an
Externí odkaz:
https://doaj.org/article/aec45e1f639d49a9987c001607b6be6d
Autor:
Mahir Karakas, Dominik Jarczak, Martin Becker, Kevin Roedl, Marylyn M. Addo, Frauke Hein, Andreas Bergmann, Jens Zimmermann, Tim-Philipp Simon, Gernot Marx, Marc Lütgehetmann, Axel Nierhaus, Stefan Kluge
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1171 (2020)
Recently, the stabilization of the endothelium has been explicitly identified as a therapeutic goal in coronavirus disease 2019 (COVID-19). Adrecizumab (HAM8101) is a first-in-class humanized monoclonal anti-Adrenomedullin (anti-ADM) antibody, target
Externí odkaz:
https://doaj.org/article/d6db0c872fae4de79599a78f5d64c5f3