Targeting of the C-Type Lectin Receptor Langerin Using Bifunctional Mannosylated Antigens

Autor: Rui-Jun Eveline Li, Tim P. Hogervorst, Silvia Achilli, Sven C. M. Bruijns, Sander Spiekstra, Corinne Vivès, Michel Thépaut, Dmitri V. Filippov, Gijs A. van der Marel, Sandra J. van Vliet, Franck Fieschi, Jeroen D. C. Codée, Yvette van Kooyk

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Langerhans cells (LCs) are antigen-presenting cells that reside in the skin. They uniquely express high levels of the C-type lectin receptor Langerin (CD207), which is an attractive target for antigen delivery in immunotherapeutic vaccination strateg

Externí odkaz: https://doaj.org/article/85f1597e8e6748afb698b1efd024ac0c

Single-molecule imaging of glycan–lectin interactions on cells with Glyco-PAINT

Autor: Tim P Hogervorst, Lorenzo Albertazzi, Ward Doelman, Jeroen D. C. Codée, Evangelia Bolli, Roger Riera, Silvia Pujals, Sander I. van Kasteren, Yan Ni

Publikováno v: Nature Chemical Biology
Nature Chemical Biology, 17, 1281-1288
Nature Chemical Biology, 17(12). Nature Publishing Group

Most lectins bind carbohydrate ligands with relatively low affinity, making the identification of optimal ligands challenging. Here we introduce a point accumulation in nanoscale topography (PAINT) super-resolution microscopy method to capture weak g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434aa92617310cef23e0644df5167354

Single-molecule imaging of glycan-lectin interactions on cells with Glyco-PAINT

Autor: Roger, Riera, Tim P, Hogervorst, Ward, Doelman, Yan, Ni, Silvia, Pujals, Evangelia, Bolli, Jeroen D C, Codée, Sander I, van Kasteren, Lorenzo, Albertazzi

Publikováno v: Nature chemical biology. 17(12)

Most lectins bind carbohydrate ligands with relatively low affinity, making the identification of optimal ligands challenging. Here we introduce a point accumulation in nanoscale topography (PAINT) super-resolution microscopy method to capture weak g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b616a7ed44fea56e4e5887982dbb360d
https://pubmed.ncbi.nlm.nih.gov/34764473

Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen

Autor: Michel Thépaut, Franck Fieschi, Corinne Vivès, Sandra J. van Vliet, Hans van den Elst, Tim Arnoldus, Sven C. M. Bruijns, Rui Jun Eveline Li, Nico J. Meeuwenoord, Gijs A. van der Marel, Herman S. Overkleeft, Tim P Hogervorst, Dmitri V. Filippov, Jeroen D. C. Codée, Silvia Achilli, Yvette van Kooyk, Chung C. Wong

Publikováno v: Frontiers in Chemistry, 7:650. Bentham Science Publishers B.V.
Frontiers in Chemistry
Frontiers in Chemistry, Vol 7 (2019)
Frontiers in chemistry, 7, 650
Li, R J E, Hogervorst, T P, Achilli, S, Bruijns, S C, Arnoldus, T, Vivès, C, Wong, C C, Thépaut, M, Meeuwenoord, N J, van den Elst, H, Overkleeft, H S, van der Marel, G A, Filippov, D V, van Vliet, S J, Fieschi, F, Codée, J D C & van Kooyk, Y 2019, ' Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen ', Frontiers in Chemistry, vol. 7, 650 . https://doi.org/10.3389/fchem.2019.00650
Frontiers in Chemistry, Frontiers Media, 2019, 7, pp.650. ⟨10.3389/fchem.2019.00650⟩
Frontiers in chemistry
Frontiers in Chemistry, 2019, 7, pp.650. ⟨10.3389/fchem.2019.00650⟩

International audience; Dendritic cells (DCs) are important initiators of adaptive immunity, and they possess a multitude of Pattern Recognition Receptors (PRR) to generate an adequate T cell mediated immunity against invading pathogens. PRR ligands

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0098e3e9ff9a53aaf120a1be6af189
https://research.vumc.nl/en/publications/72064e25-c174-48a8-a11c-864231636f40

Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7

Autor: Geoffroy P.P. Gential, Ferry Ossendorp, Tim P Hogervorst, Herman S. Overkleeft, Gijsbert A. van der Marel, Michel J. van de Graaff, Jeroen D. C. Codée, Elena Tondini, Dmitri V. Filippov

Publikováno v: Bioorganic and Medicinal Chemistry Letters, 29(11), 1340-1344
Bioorganic and Medicinal Chemistry Letters

Covalent linking of immunogenic oligopeptides with synthetic Toll-like receptor ligands is a useful approach to develop self-adjuvanting vaccines. In particular, small-molecule based agonists of Toll-like receptor 7 (TLR7) that are derived from 8-oxo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0d510528e496a075dea1ae944facda
https://pubmed.ncbi.nlm.nih.gov/30952595