Výsledky vyhledávání - "Tim N. C. Wells"

Akademický článek

A phenotypic screen of the Global Health Priority Box identifies an insecticide with anthelmintic activity

Autor: Harrison T. Shanley, Aya C. Taki, Joseph J. Byrne, Nghi Nguyen, Tim N. C. Wells, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser

Publikováno v: Parasites & Vectors, Vol 17, Iss 1, Pp 1-12 (2024)

Abstract Background Infection with parasitic nematodes (helminths), particularly those of the order Strongylida (such as Haemonchus contortus), can cause significant and burdensome diseases in humans and animals. Widespread drug (anthelmintic) resist

Externí odkaz: https://doaj.org/article/c4b3a1f5948547319889689e50b53154

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Akademický článek

A High-Throughput Phenotypic Screen of the ‘Pandemic Response Box’ Identifies a Quinoline Derivative with Significant Anthelmintic Activity

Autor: Harrison T. Shanley, Aya C. Taki, Joseph J. Byrne, Abdul Jabbar, Tim N. C. Wells, Kirandeep Samby, Peter R. Boag, Nghi Nguyen, Brad E. Sleebs, Robin B. Gasser

Publikováno v: Pharmaceuticals, Vol 15, Iss 2, p 257 (2022)

Parasitic nematodes cause diseases in livestock animals and major economic losses to the agricultural industry worldwide. Nematodes of the order Strongylida, including Haemonchus contortus, are particularly important. The excessive use of anthelminti

Externí odkaz: https://doaj.org/article/f387b558c3dd43088d72f1557f097ddd

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Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor

Autor: Tim N. C. Wells, Iain C. A. F. Robinson, Dave A. S. Gill, Pamela A. Houston, Rhos Davies, Nigel Loveridge, Nichola M. Thompson

Publikováno v: Endocrinology. 145(1)

Ghrelin promotes fat accumulation, despite potent stimulation of the lipolytic hormone, GH. The function of the major circulating isoform of ghrelin, des-octanoyl ghrelin, is unclear, because it does not activate the GH secretagogue receptor (GHS-R1a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ade5ea8d186b15d6a5b47584eea9c9c
https://pubmed.ncbi.nlm.nih.gov/14551228

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Protection of an unstable reaction intermediate examined with linear free energy relationships in tyrosyl-tRNA synthetase

Autor: Tim N. C. Wells, Alan R. Fersht

Publikováno v: Biochemistry. 28:9201-9209

Linear free energy relationships (LFERs) are powerful tools in the search to understand the relationship between molecular structure and activity. They frequently link the changes in the rate constants for a reaction to changes in the equilibrium con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded39d64487a7f4076e93fc160e0a691
https://doi.org/10.1021/bi00449a036

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