Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tim N. Barrett"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1617-1626 (2020)
Integrin inhibitors based on the tripeptide sequence Arg–Gly–Asp (RGD) are potential therapeutics for the treatment of idiopathic pulmonary fibrosis (IPF). Herein, we describe an expeditious three-step synthetic sequence of Horner–Wadsworth–E
Externí odkaz:
https://doaj.org/article/159af02f23c14708a242e80642411380
Publikováno v:
The Journal of Organic Chemistry. 86:3583-3604
Substituted arylethylamines represent a key structural motif in natural, pharmaceutical, and agrochemical compounds. Access to such scaffolds has been the subject of long-standing synthetic interest. Herein, we report the synthesis of such scaffolds
Autor:
Jennifer M. Clark, Fernando Salgado-Polo, Simon J. F. Macdonald, Tim N. Barrett, Anastassis Perrakis, Craig Jamieson
Autotaxin (ATX) facilitates the hydrolysis of lysophosphatidylcholine to lysophosphatidic acid (LPA), a bioactive phospholipid, which facilitates a diverse range of cellular effects in multiple tissue types. Abnormal LPA expression can lead to the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb65acde0750fd7323d1ce9b5b2095b
https://strathprints.strath.ac.uk/80159/7/Clark_etal_JMC_2022_Structure_based_design_of_a_novel_class_of_autotaxin_inhibitors.pdf
https://strathprints.strath.ac.uk/80159/7/Clark_etal_JMC_2022_Structure_based_design_of_a_novel_class_of_autotaxin_inhibitors.pdf
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1617-1626 (2020)
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1617-1626 (2020)
Integrin inhibitors based on the tripeptide sequence Arg–Gly–Asp (RGD) are potential therapeutics for the treatment of idiopathic pulmonary fibrosis (IPF). Herein, we describe an expeditious three-step synthetic sequence of Horner–Wadsworth–E
Autor:
Panayiotis A. Procopiou, Simon J. F. Macdonald, Ben S. Barksby, Jeni Luckett, Richard P. Marshall, Yim Man, Valerie S. Morrison, Lee A. Borthwick, Alex L Wilkinson, R. Gisli Jenkins, Elaine Gower, Rory Barnes, Alison E. John, Richard J. D. Hatley, John Barrett, K. Tao Pun, James A. Roper, Tim N. Barrett, Andrew J. Fisher, Robert J. Slack, Rachel A. Burgoyne
Publikováno v:
European journal of pharmacology. 913
Fibrosis is the formation of scar tissue due to injury or long-term inflammation and is a leading cause of morbidity and mortality. Activation of the pro-fibrotic cytokine transforming growth factor-β (TGFβ) via the alpha-V beta-6 (αvβ6) integrin
Publikováno v:
The Journal of organic chemistry. 86(4)
Substituted arylethylamines represent a key structural motif in natural, pharmaceutical, and agrochemical compounds. Access to such scaffolds has been the subject of long-standing synthetic interest. Herein, we report the synthesis of such scaffolds
Autor:
Rhys A, Lippa, John, Barrett, Sandeep, Pal, James E, Rowedder, John A, Murphy, Tim N, Barrett
Publikováno v:
European journal of medicinal chemistry. 208
Integrins α
Autor:
Richard P. Marshall, John Martin Pritchard, Josie Morrell, Simon J. F. Macdonald, Seble Lemma, John F. Barrett, Paula Saklatvala, Robert J. Slack, Panayiotis A. Procopiou, Joelle Le, Tim N. Barrett, Ashley Paul Hancock, James E. Rowedder, Matthew H. J. Crawford, Anderson Niall Andrew, Giovanni Vitulli, Colin J. Suckling, Brendan J. Fallon, Steven L. Sollis, Lee R. Thorp
Publikováno v:
Journal of Medicinal Chemistry. 61:8417-8443
A series of 3-aryl(pyrrolidin-1-yl)butanoic acids were synthesized using a diastereoselective route, via a rhodium catalyzed asymmetric 1,4-addition of arylboronic acids in the presence of (R)-BINAP to a crotonate ester to provide the (S) absolute co
Publikováno v:
Tetrahedron: Asymmetry. 28:1384-1393
The absolute configuration of two novel αvβ6 integrin inhibitors was established via degradation to the corresponding C3-aryl substituted butyrolactone. The configuration of the resulting lactones was established by asymmetric synthesis using 1,4-a
Autor:
Tim N, Barrett, Jonathan A, Taylor, Daniel, Barker, Panayiotis A, Procopiou, James D F, Thompson, John, Barrett, Joelle, Le, Sean M, Lynn, Peter, Pogany, Cassie, Pratley, John M, Pritchard, James A, Roper, James E, Rowedder, Robert J, Slack, Giovanni, Vitulli, Simon J F, Macdonald, William J, Kerr
Publikováno v:
Journal of medicinal chemistry. 62(16)
A quaternary ammonium betaine