Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tim Mierzwa"'
Autor:
Yu Cong, Julie Dyall, Brit J Hart, Lisa Evans DeWald, Joshua C Johnson, Elena Postnikova, Huanying Zhou, Robin Gross, Oscar Rojas, Isis Alexander, Nicole Josleyn, Tengfei Zhang, Julia Michelotti, Krisztina Janosko, Pamela J Glass, Mike Flint, Laura K McMullan, Christina F Spiropoulou, Tim Mierzwa, Rajarshi Guha, Paul Shinn, Sam Michael, Carleen Klumpp-Thomas, Crystal McKnight, Craig Thomas, Ann E Eakin, Kathleen G O'Loughlin, Carol E Green, Paul Catz, Jon C Mirsalis, Anna N Honko, Gene G Olinger, Richard S Bennett, Michael R Holbrook, Lisa E Hensley, Peter B Jahrling
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166318 (2016)
In the fall of 2014, an international news agency reported that patients suffering from Ebola virus disease (EVD) in Liberia were treated successfully with lamivudine, an antiviral drug used to treat human immunodeficiency virus-1 and hepatitis B vir
Externí odkaz:
https://doaj.org/article/46cb98f2678f4277aab2f35637509fbf
Autor:
Lars Juhl Jensen, Dimitrios Metaxatos, Biju Mathew, Gergely Zahoranszky-Kohalmi, Tim Mierzwa, Samuel G. Michael, Ewy Mathé, Alexander G. Godfrey, Praveen Kumar, Reid Simon, Tudor I. Oprea, Matthew D. Hall, Busola Grillo, Mark Backus, Laura Brovold, Ivan Grishagin, Manideep Gurumurthy, Jordi Mestres, Vishal B. Siramshetty
Publikováno v:
Zahoránszky-Kőhalmi, G, Siramshetty, V B, Kumar, P, Gurumurthy, M, Grillo, B, Mathew, B, Metaxatos, D, Backus, M, Mierzwa, T, Simon, R, Grishagin, I, Brovold, L, Mathé, E A, Hall, M D, Michael, S G, Godfrey, A G, Mestres, J, Jensen, L J & Oprea, T I 2022, ' A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research ', Journal of Chemical Information and Modeling, vol. 62, no. 3, pp. 718-729 . https://doi.org/10.1021/acs.jcim.1c00431
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
MotivationIn the event of an outbreak due to an emerging pathogen, time is of the essence to contain or to mitigate the spread of the disease. Drug repositioning is one of the strategies that has the potential to deliver therapeutics relatively quick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648afadd992dce6bf02fee25d5c5f354
https://doi.org/10.1021/acs.jcim.1c00431
https://doi.org/10.1021/acs.jcim.1c00431
Autor:
Manisha Pradhan, Amit Viraktamath, Stephen C. Kales, Alexey V. Zakharov, Alex Renn, Tongan Zhao, Miao Xu, Bolormaa Baljinnyam, Catherine Z. Chen, Ke Wang, Sam Michael, Mark Backus, Zina Itkin, Donald C. Lo, Anton Simeonov, Kyle R. Brimacombe, Tara Eicher, Quinlin M Hanson, Carleen Klumpp-Thomas, Wei Zhu, Ying Fu, Tim Mierzwa, Kirill Gorshkov, Min Shen, Emily M. Lee, Xin Hu, Wei Zheng, Lu Chen, Ewy Mathé, Matthew D. Hall, Paul Shinn, Kelli M. Wilson, Richard T. Eastman, Andrew Patt, Hui Guo, Jonathan H. Shrimp, Marc Ferrer
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
The National Center for Advancing Translational Sciences (NCATS) has developed an online open science data portal for its COVID-19 drug repurposing campaign – named OpenData – with the goal of making data across a range of SARS-CoV-2 related assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844a465ce30f495a81fd9bfeb01c4f10
https://doi.org/10.1101/2020.06.04.135046
https://doi.org/10.1101/2020.06.04.135046
Autor:
Paul, Shinn, Lu, Chen, Marc, Ferrer, Zina, Itkin, Carleen, Klumpp-Thomas, Crystal, McKnight, Sam, Michael, Tim, Mierzwa, Craig, Thomas, Kelli, Wilson, Rajarshi, Guha
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1939
The identification of drug combinations as alternatives to single-agent therapeutics has traditionally been a slow, largely manual process. In the last 10 years, high-throughput screening platforms have been developed that enable routine screening of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e2d21205db6f736d6b5add5e449339f
https://pubmed.ncbi.nlm.nih.gov/30848454
https://pubmed.ncbi.nlm.nih.gov/30848454
Autor:
Paul Shinn, Lu Chen, Crystal McKnight, Carleen Klumpp-Thomas, Rajarshi Guha, Kelli M. Wilson, Zina Itkin, Craig J. Thomas, Tim Mierzwa, Marc Ferrer, Sam Michael
Publikováno v:
Methods in Molecular Biology ISBN: 9781493990887
The identification of drug combinations as alternatives to single-agent therapeutics has traditionally been a slow, largely manual process. In the last 10 years, high-throughput screening platforms have been developed that enable routine screening of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::508b2efd9d30cf57341f04abcfa5c455
https://doi.org/10.1007/978-1-4939-9089-4_2
https://doi.org/10.1007/978-1-4939-9089-4_2
Autor:
Richard S. Bennett, Crystal McKnight, Michael R. Holbrook, Judith M. White, Tim Mierzwa, Ian Crozier, Elena Postnikova, Julia Michelotti, Lisa M. Johansen, Pamela J. Glass, Carleen Klumpp-Thomas, Lisa Evans DeWald, Nicole Deiuliis, Craig J. Thomas, Julie Dyall, Rajarshi Guha, Paul Shinn, Brit J. Hart, Elizabeth A. Nelson, Gene G. Olinger, Huanying Zhou, Peter B. Jahrling, Walter M Vargas, Patrick J. Morris, Lisa E. Hensley, James Logue, Robin Gross
Publikováno v:
The Journal of infectious diseases. 218(suppl_5)
Background A need to develop therapeutics to treat Ebola virus disease patients in remote and resource-challenged settings remains in the wake of the 2013-2016 epidemic in West Africa. Toward this goal, we screened drugs under consideration as treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ed0f45178e5359cd31cc8caab2f71f
https://pubmed.ncbi.nlm.nih.gov/29939303
https://pubmed.ncbi.nlm.nih.gov/29939303
Autor:
Ian S. Goldlust, Christopher A. LeClair, Paresma R. Patel, David J. Maloney, Adam Yasgar, Jonathan M. Keller, Martin J. Walsh, Christopher P. Austin, Brian D. Peyser, Paul Shinn, Rajarshi Guha, Ganesha Rai, Damien Y. Duveau, Sam Michael, Marc Ferrer, William Leister, Dongbo Liu, Wenwei Huang, Craig J. Thomas, Anton Simeonov, Bryan T. Mott, Crystal McKnight, Ryan M. Young, Matthew B. Boxer, Jian-kang Jiang, Louis M. Staudt, Lesley A. Mathews Griner, Scott E. Martin, Tim Mierzwa, Ajit Jadhav
Publikováno v:
Proceedings of the National Academy of Sciences. 111:2349-2354
The clinical development of drug combinations is typically achieved through trial-and-error or via insight gained through a detailed molecular understanding of dysregulated signaling pathways in a specific cancer type. Unbiased small-molecule combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfc7a9978d973e729a14868b89476e1
https://doi.org/10.1073/pnas.1311846111
https://doi.org/10.1073/pnas.1311846111
Autor:
Michael R. Holbrook, Paul Catz, Tim Mierzwa, Mike Flint, Yu Cong, Lisa Evans DeWald, Krisztina Janosko, Carol E. Green, Sam Michael, Lisa E. Hensley, Julia Michelotti, Robin Gross, Joshua C. Johnson, Laura K. McMullan, Elena Postnikova, Oscar Rojas, Crystal McKnight, Richard S. Bennett, Rajarshi Guha, Carleen Klumpp-Thomas, Gene G. Olinger, Kathleen O’Loughlin, Peter B. Jahrling, Craig J. Thomas, Julie Dyall, Christina F. Spiropoulou, Jon C. Mirsalis, Pamela J. Glass, Huanying Zhou, Paul Shinn, Tengfei Zhang, Brit J. Hart, Isis Alexander, Anna N. Honko, Ann E. Eakin, Nicole Josleyn
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166318 (2016)
PLoS ONE
PLoS ONE
In the fall of 2014, an international news agency reported that patients suffering from Ebola virus disease (EVD) in Liberia were treated successfully with lamivudine, an antiviral drug used to treat human immunodeficiency virus-1 and hepatitis B vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc1ca0ca24009e6022abdd84310d0fe
http://europepmc.org/articles/PMC5130197?pdf=render
http://europepmc.org/articles/PMC5130197?pdf=render
Autor:
Norinne Lacerda-Queiroz, Katy S. Sherlach, Sam Michael, Hongmao Sun, Rajarshi Guha, Amila Siriwardana, Jing Yuan, Craig J. Thomas, Shaun D. Fontaine, Dongbo Liu, Paul D. Roepe, Paresma R. Patel, Adam R. Renslo, Pwint Khine, James Inglese, Nima Aghdam, Xin-zhuan Su, Paul Shinn, Monica Kasbekar, Bryan T. Mott, Crystal McKnight, Marc Ferrer, Richard T. Eastman, Tim Mierzwa, Lesley Mathews-Griner
Publikováno v:
Scientific Reports
Drug resistance in Plasmodium parasites is a constant threat. Novel therapeutics, especially new drug combinations, must be identified at a faster rate. In response to the urgent need for new antimalarial drug combinations we screened a large collect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462a000835ada1dc3f2fd5c29b2aea2b