Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Tim Menzen"'
Autor:
Cornelia Hiemenz, Nadine Baumeister, Constanze Helbig, Andrea Hawe, Sabrina Babutzka, Stylianos Michalakis, Wolfgang Friess, Tim Menzen
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101162- (2023)
Recombinant adeno-associated viruses (rAAVs) are attractive therapeutic viral vectors for gene delivery. To ensure the efficacy and safety of rAAV-based therapies, comprehensive characterization of the adeno-associated virus (AAV) capsids is essentia
Externí odkaz:
https://doaj.org/article/021bc972a55c4085adb2165aff1ec1da
Autor:
Brecht Vanbillemont, Anna-Lena Greiner, Vanessa Ehrl, Tim Menzen, Wolfgang Friess, Andrea Hawe
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100180- (2023)
Freeze-drying is a time and cost-intensive process. The primary drying phase is the main target in a process optimization exercise. Biopharmaceuticals require an amorphous matrix for stabilization, which may collapse during primary drying if the crit
Externí odkaz:
https://doaj.org/article/e764e9c5ffc64cc7acc9036b48afe182
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody drugs should exhibit not only high-binding affinity for their target antigens but also favorable physicochemical drug-like properties. Such drug-like biophysical properties are essential for the successful development of antibody dru
Externí odkaz:
https://doaj.org/article/375ca2578f7d4343a49f80dafa044d39
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 703 (2023)
There is a lack of methods to predict the isothermal crystallization behavior of amorphous freeze-dried formulations stored below the glass transition temperature. This study applies isothermal microcalorimetry to predict long-term crystallization du
Externí odkaz:
https://doaj.org/article/de521f13f0264880a1a2f763a8e97fb9
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1735 (2021)
Studying the thermal history and relaxation of solid amorphous drug product matrices by calorimetry is a well-known approach, particularly in the context of correlating the matrix parameters with the long-term stability of freeze-dried protein drug p
Externí odkaz:
https://doaj.org/article/f76e08e7ad724565bec4b26da6e39560
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1695 (2021)
Primary containers made of cyclic olefin polymer (COP) have recently gained attention since they may overcome several risks and shortcomings of glass containers as they exhibit a high break resistance, biocompatibility, and homogeneous heat transfer
Externí odkaz:
https://doaj.org/article/67e7c9e6c96c443db4910cf4fe93147d
Autor:
Ruth Rieser, Johanna Koch, Greta Faccioli, Klaus Richter, Tim Menzen, Martin Biel, Gerhard Winter, Stylianos Michalakis
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 748 (2021)
Recombinant adeno-associated virus (rAAV) vectors have evolved as one of the most promising technologies for gene therapy due to their good safety profile, high transduction efficacy, and long-term gene expression in nondividing cells. rAAV-based gen
Externí odkaz:
https://doaj.org/article/34815d04c6634e498a6c77739a3c1b86
Autor:
Anian, Thaller, Lukas, Schmauder, Wolfgang, Frieß, Gerhard, Winter, Tim, Menzen, Andrea, Hawe, Klaus, Richter
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 182:152-156
During the SARS-CoV2 pandemic mRNA vaccines in the form of lipid nanoparticles (LNPs) containing the mRNA, have set the stage for a new area of vaccines. Analytical methods to quantify changes in size and structure of LNPs are crucial, as changes in
Publikováno v:
Journal of Pharmaceutical Sciences. 111:2288-2298
Adeno-associated virus (AAV) vectors have evolved as one of the most promising delivery systems for gene therapy. The current standard for AAV vector storage is deep-freezing below -60 °C. While this allows for long-term vector storage without loss
Autor:
Cornelia Hiemenz, Anabel Pacios-Michelena, Constanze Helbig, Valerija Vezočnik, Michael Strebl, Felix Nikels, Andrea Hawe, Patrick Garidel, Tim Menzen
Publikováno v:
Journal of Pharmaceutical Sciences.