Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Tim Maiwald"'
Autor:
Yildirim Dogan, Cecilia N. Barese, Jeffrey W. Schindler, John K. Yoon, Zeenath Unnisa, Swaroopa Guda, Mary E. Jacobs, Christine Oborski, Tim Maiwald, Diana L. Clarke, Axel Schambach, Richard Pfeifer, Claudia Harper, Chris Mason, Niek P. van Til
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 464-487 (2022)
Pompe disease is a rare genetic neuromuscular disorder caused by acid α-glucosidase (GAA) deficiency resulting in lysosomal glycogen accumulation and progressive myopathy. Enzyme replacement therapy, the current standard of care, penetrates poorly i
Externí odkaz:
https://doaj.org/article/19aee40652b94df1a4979d0e41238f5c
Autor:
Thomas Zimmer, Josef Bock, Fred Buchali, Pascal Chevalier, Michael Collisi, Bjorn Debaillie, Marina Deng, Philippe Ferrari, Sebastien Fregonese, Christophe Gaquiere, Haitham Ghanem, Horst Hettrich, Alper Karakuzulu, Tim Maiwald, Marc Margalef-Rovira, Caroline Maye, Michael Moller, Anindya Mukherjee, Holger Rucker, Paulius Sakalas, Rolf Schmid, Karina Disch, Karsten Schuh, Wolfgang Templ, Akshay Visweswaran, Thomas Zwick
Publikováno v:
IEEE Journal of Microwaves, Vol 1, Iss 1, Pp 288-298 (2021)
This paper gives an overall picture from BiCMOS technologies up to THz systems integration, which were developed in the European Research project TARANTO. The European high performance BiCMOS technology platforms are presented, which have special adv
Externí odkaz:
https://doaj.org/article/3bc0679a9ae0498f94cba80626998dd3
Autor:
Frédérique Kok, Marcus Rosenblatt, Melissa Teusel, Tamar Nizharadze, Vladimir Gonçalves Magalhães, Christopher Dächert, Tim Maiwald, Artyom Vlasov, Marvin Wäsch, Silvana Tyufekchieva, Katrin Hoffmann, Georg Damm, Daniel Seehofer, Tobias Boettler, Marco Binder, Jens Timmer, Marcel Schilling, Ursula Klingmüller
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 7, Pp 1-32 (2020)
Abstract Tightly interlinked feedback regulators control the dynamics of intracellular responses elicited by the activation of signal transduction pathways. Interferon alpha (IFNα) orchestrates antiviral responses in hepatocytes, yet mechanisms that
Externí odkaz:
https://doaj.org/article/0f487b7e463c482f8349a29b3ad0fd4c
Autor:
Katharina Robichon, Tim Maiwald, Marcel Schilling, Annette Schneider, Joschka Willemsen, Florian Salopiata, Melissa Teusel, Clemens Kreutz, Christian Ehlting, Jun Huang, Sajib Chakraborty, Xiaoyun Huang, Georg Damm, Daniel Seehofer, Philipp A Lang, Johannes G Bode, Marco Binder, Ralf Bartenschlager, Jens Timmer, Ursula Klingmüller
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008461 (2020)
The induction of an interferon-mediated response is the first line of defense against pathogens such as viruses. Yet, the dynamics and extent of interferon alpha (IFNα)-induced antiviral genes vary remarkably and comprise three expression clusters:
Externí odkaz:
https://doaj.org/article/8fda1d502fa54cb7b94e37be45e89837
Autor:
Tim Maiwald, Helge Hass, Bernhard Steiert, Joep Vanlier, Raphael Engesser, Andreas Raue, Friederike Kipkeew, Hans H Bock, Daniel Kaschek, Clemens Kreutz, Jens Timmer
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162366 (2016)
In systems biology, one of the major tasks is to tailor model complexity to information content of the data. A useful model should describe the data and produce well-determined parameter estimates and predictions. Too small of a model will not be abl
Externí odkaz:
https://doaj.org/article/e74019cad76e473baab573344e3c9a94
Autor:
Lorenza A D'Alessandro, Regina Samaga, Tim Maiwald, Seong-Hwan Rho, Sandra Bonefas, Andreas Raue, Nao Iwamoto, Alexandra Kienast, Katharina Waldow, Rene Meyer, Marcel Schilling, Jens Timmer, Steffen Klamt, Ursula Klingmüller
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 4, p e1004192 (2015)
Signaling pathways are characterized by crosstalk, feedback and feedforward mechanisms giving rise to highly complex and cell-context specific signaling networks. Dissecting the underlying relations is crucial to predict the impact of targeted pertur
Externí odkaz:
https://doaj.org/article/b10a8ab9465a406389c2ad84cb9852d0
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 7, p e1000440 (2009)
Transmembrane channel proteins play pivotal roles in maintaining the homeostasis and responsiveness of cells and the cross-membrane electrochemical gradient by mediating the transport of ions and molecules through biological membranes. Therefore, com
Externí odkaz:
https://doaj.org/article/ad18900cb9ce46fb929f70f8b418a3ca
Autor:
Tim Maiwald, Teng Li, George-Roberto Hotopan, Katharina Kolb, Karina Disch, Julian Potschka, Alexander Haag, Marco Dietz, Björn Debaillie, Thomas Zwick, Klaus Aufinger, Dieter Ferling, Robert Weigel, Akshay Visweswaran
Publikováno v:
Proceedings of the IEEE. 111:220-256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::036e81be9f73e554df30698ba12b4759
https://doi.org/10.1109/jproc.2023.3240127
https://doi.org/10.1109/jproc.2023.3240127
Publikováno v:
ESSCIRC 2022- IEEE 48th European Solid State Circuits Conference (ESSCIRC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe403446c744d8d4ebe79ecb551c6060
https://doi.org/10.1109/esscirc55480.2022.9911462
https://doi.org/10.1109/esscirc55480.2022.9911462
Publikováno v:
Appl Clin Inform
Background Even though clinical trials are indispensable for medical research, they are frequently impaired by delayed or incomplete patient recruitment, resulting in cost overruns or aborted studies. Study protocols based on real-world data with pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef0159571ef764c70232157d0ea251d
https://doi.org/10.1055/s-0040-1721010
https://doi.org/10.1055/s-0040-1721010