Evaluation of steroid receptor function by gene targeting in mice

Autor: Stefan Berger, Günther Schütz, Tim M. Wintermantel, Erich Greiner

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 93:107-112

Corticosteroid hormones regulate a variety of developmental, physiological and pathological processes via their cognate receptors, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR). Using modern genetic technologies, including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da5e88d93e967b455a7589b25c9779a
https://doi.org/10.1016/j.jsbmb.2004.12.033

Conditional inactivation of the E-cadherin gene in thyroid follicular cells affects gland development but does not impair junction formation

Autor: Barbara D'Andrea, Günther Schütz, Lucio Nitsch, Tim M. Wintermantel, Oreda Boussadia, Roberto Di Lauro, Gaetano Calì, Rolf Kemler, Mariastella Zannini, Daniela Terracciano, Mario De Felice, Andrea Affuso, Daniel Silberschmidt, Elena Amendola, Patrizia Rubini, Carlo Tacchetti

Publikováno v: Endocrinology (Philadelphia) 148 (2007): 2737–2746. doi:10.1210/en.2006-1344
info:cnr-pdr/source/autori:Cali G, Zannini M, Rubini P, Tacchetti C, D'Andrea B, Affuso A, Wintermantel T, Boussadia O, Terracciano D, Silberschmidt D, Amendola E, De Felice M, Schutz G, Kemler R, Di Lauro R, Nitsch L./titolo:Conditional inactivation of the E-cadherin gene in thyroid follicular cells affects gland development but does not impair junction formation/doi:10.1210%2Fen.2006-1344/rivista:Endocrinology (Philadelphia)/anno:2007/pagina_da:2737/pagina_a:2746/intervallo_pagine:2737–2746/volume:148

We have conditionally inactivated the E-cadherin gene in the thyroid follicular cells of mouse embryo to unravel its role in thyroid development. We used the Cre-loxP system in which the Cre-recombinase was expressed under the control of the tissue-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27d5e36792bd18c8d8802965d408a55

Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility

Autor: Allan E. Herbison, Günther Schütz, Kenneth S. Korach, Cristian A. Pérez, Martin G. Todman, Erich Greiner, Rebecca Campbell, Tim M. Wintermantel, Robert Porteous, Dagmar Bock, Hermann Josef Gröne

Publikováno v: Neuron. 52(2)

The mechanisms through which estrogen regulates gonadotropin-releasing hormone (GnRH) neurons to control mammalian ovulation are unknown. We found that estrogen positive feedback to generate the preovulatory gonadotropin surge was normal in estrogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c64c0616b2f685054639c46d8707e3
https://pubmed.ncbi.nlm.nih.gov/17046690

The epithelial glucocorticoid receptor is required for the normal timing of cell proliferation during mammary lobuloalveolar development but is dispensable for milk production

Autor: Verena Fleig, Erich Greiner, Tim M. Wintermantel, Dagmar Bock, Günther Schütz

Publikováno v: Molecular endocrinology (Baltimore, Md.). 19(2)

Glucocorticoids have been shown to influence mammary gland function in vivo and to stimulate milk protein gene expression in vitro. Here, we describe the generation and analysis of a mouse model to study glucocorticoid receptor (GR, NR3C1) function i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb6da035ab81b968122f19460f03524
https://pubmed.ncbi.nlm.nih.gov/15471946

Targeting mammary epithelial cells using a bacterial artificial chromosome

Autor: Tim M, Wintermantel, Anja K, Mayer, Günther, Schütz, Erich F, Greiner

Publikováno v: Genesis (New York, N.Y. : 2000). 33(3)

We describe the generation of transgenic mouse lines expressing Cre recombinase in epithelial cells of the lactating mammary gland. As an expression vector, we used a P1-derived bacterial artificial chromosome (PAC) which harbors the gene for the sec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::344b6370ff3124f7304af30579f815a6
https://pubmed.ncbi.nlm.nih.gov/12124945