Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Tim M. Coskran"'
Autor:
Hans-Peter Gerber, Chunli Huang, Leslie A. Obert, Magali Guffroy, Germaine Boucher, Richard Goldstein, Karen Walters, Danielle Sullivan, Hadi Falahatpisheh, William J. Reagan, John M. Kreeger, Nasir K. Khan, Tim M. Coskran, Kathleen Biddle, Richard P. Giovanelli, Sharon A. Sokolowski, Martin Finkelstein
Publikováno v:
Clinical Cancer Research. 23:1760-1770
Purpose: Adverse reactions reported in patients treated with antibody–calicheamicin conjugates such as gemtuzumab ozogamicin (Mylotarg) and inotuzumab ozogamicin include thrombocytopenia and sinusoidal obstruction syndrome (SOS). The objective of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22cc14d6604e232f8e412e34715ae0ed
https://doi.org/10.1158/1078-0432.ccr-16-0939
https://doi.org/10.1158/1078-0432.ccr-16-0939
Autor:
Jon Golas, Eric L. Powell, Tania Franks, Pamela Whalen, Pamela Vizcarra, Jesse Qian, Marc D. Roy, Hans-Peter Gerber, Eric Tucker, Wenyan Zhong, Cory L. Painter, Shibing Deng, Steven Pirie-Shepherd, Tim M. Coskran, Dena Marrinucci
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0179561 (2017)
PLoS ONE
PLoS ONE
The fetal oncogene 5T4 is a cell surface protein, with overexpression observed in a variety of cancers as compared to normal adult tissue. The ability to select patients with tumors that express high levels of 5T4 may enrich a clinical trial cohort w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a886502e1986efd0c460146a8d4426
http://europepmc.org/articles/PMC5519031?pdf=render
http://europepmc.org/articles/PMC5519031?pdf=render
Autor:
Jitesh P. Jani, Gerrit Los, Kajiji Shama M, Bruce D. Cohen, Green Larry L, Kevin Coleman, Mary Campbell, Jinghai J. Xu, Elsa G. Barbacci-Tobin, Vahe Bedian, Konstantinos Tsaparikos, Jean-Martin Lapointe, Patrick Vincent, Boris A. Chrunyk, Neil R. Michaud, Stephen M. Hillerman, David F. Gebhard, Tim M. Coskran, George A. Karam, Margaret C. Dunn, Elisabeth Knauth, Stefan J. Steyn, Henry Putz, Gary Borzillo
Publikováno v:
mAbs. 4:710-723
The c-Met proto-oncogene is a multifunctional receptor tyrosine kinase that is stimulated by its ligand, hepatocyte growth factor (HGF), to induce cell growth, motility and morphogenesis. Dysregulation of c-Met function, through mutational activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7724a3acb9187edf4bc1c797bd35ec1f
https://doi.org/10.4161/mabs.22160
https://doi.org/10.4161/mabs.22160
Autor:
Tim M. Coskran, Robin J. Kleiman, Margaret B. Wilhelms, Daniel Morton, Michele M. O'Donnell, Wendy O. Adamowicz, Kathleen B. Muravnick, Frank S. Menniti, Diane Stephenson
Publikováno v:
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 57(10)
Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. PDE2A is an evolutionarily conserved cGMP-stimulated cAMP and cGMP PDE. In the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e580f08ac27738a12fe0e00fa0d462d3
https://pubmed.ncbi.nlm.nih.gov/19506089
https://pubmed.ncbi.nlm.nih.gov/19506089