Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tim M J Ewoldt"'
Autor:
Sarah Dräger, Tim M. J. Ewoldt, Alan Abdulla, Wim J. R. Rietdijk, Nelianne Verkaik, Christian Ramakers, Evelien de Jong, Michael Osthoff, Birgit C. P. Koch, Henrik Endeman
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 270 (2024)
Model-informed precision dosing (MIPD) might be used to optimize antibiotic treatment. Procalcitonin (PCT) is a biomarker for severity of infection and response to antibiotic treatment. The aim of this study was to assess the impact of MIPD on the co
Externí odkaz:
https://doaj.org/article/20dfc43e81b74cc2904b0c650262e4d7
Autor:
Tim M. J. Ewoldt, Alan Abdulla, Puck van den Broek, Nicole Hunfeld, Soma Bahmany, Anouk E. Muller, Diederik Gommers, Suzanne Polinder, Henrik Endeman, Inge Spronk, Birgit C. P. Koch
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Recent studies demonstrated that failure of achieving pharmacodynamic targets of commonly used antibiotics is common in critically ill patients. Therapeutic drug monitoring (TDM) can contribute to optimize the exposure of beta-lac
Externí odkaz:
https://doaj.org/article/ddd085123370440f945e9846c156ba88
Autor:
André Wieringa, Tim M. J. Ewoldt, Ravish N. Gangapersad, Matthias Gijsen, Nestor Parolya, Chantal J. A. R. Kats, Isabel Spriet, Henrik Endeman, Jasper J. Haringman, Reinier M. van Hest, Birgit C. P. Koch, Alan Abdulla
Publikováno v:
Antibiotics, Vol 12, Iss 12, p 1674 (2023)
In the intensive care unit (ICU), infection-related mortality is high. Although adequate antibiotic treatment is essential in infections, beta-lactam target non-attainment occurs in up to 45% of ICU patients, which is associated with a lower likeliho
Externí odkaz:
https://doaj.org/article/67118294995346ea8290cb08a7f17209
Autor:
Alan Abdulla, Annemieke Dijkstra, Nicole G. M. Hunfeld, Henrik Endeman, Soma Bahmany, Tim M. J. Ewoldt, Anouk E. Muller, Teun van Gelder, Diederik Gommers, Birgit C. P. Koch
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-12 (2020)
Abstract Background Early and appropriate antibiotic dosing is associated with improved clinical outcomes in critically ill patients, yet target attainment remains a challenge. Traditional antibiotic dosing is not suitable in critically ill patients,
Externí odkaz:
https://doaj.org/article/0f154ec3e09242a69e716dee85ab5a45
Autor:
Letao Li, Sebastiaan D. T. Sassen, Tim M. J. Ewoldt, Alan Abdulla, Nicole G. M. Hunfeld, Anouk E. Muller, Brenda C. M. de Winter, Henrik Endeman, Birgit C. P. Koch
Publikováno v:
Antibiotics, Vol 12, Iss 2, p 383 (2023)
The number of pharmacokinetic (PK) models of meropenem is increasing. However, the daily role of these PK models in the clinic remains unclear, especially for critically ill patients. Therefore, we evaluated the published meropenem models on real-wor
Externí odkaz:
https://doaj.org/article/aa2133f593ba423898dabeb780442696
Autor:
Tim M. J. Ewoldt, Alan Abdulla, Wim J. R. Rietdijk, Anouk E. Muller, Brenda C. M. de Winter, Nicole G. M. Hunfeld, Ilse M. Purmer, Peter van Vliet, Evert-Jan Wils, Jasper Haringman, Annelies Draisma, Tom A. Rijpstra, Attila Karakus, Diederik Gommers, Henrik Endeman, Birgit C. P. Koch
Publikováno v:
Intensive Care Medicine, 48(12), 1760-1771. Springer-Verlag
PURPOSE: Individualising drug dosing using model-informed precision dosing (MIPD) of beta-lactam antibiotics and ciprofloxacin has been proposed as an alternative to standard dosing to optimise antibiotic efficacy in critically ill patients. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28aa6ee40e28707832669f6466335c8
http://www.scopus.com/inward/record.url?scp=85141693147&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85141693147&partnerID=8YFLogxK
Autor:
Anouk E. Muller, Tim M J Ewoldt, Birgit C. P. Koch, Puck van den Broek, Alan Abdulla, Henrik Endeman
Publikováno v:
Therapeutic Drug Monitoring, 44(1), 112-120. Lippincott Williams & Wilkins
BACKGROUND: With increasing knowledge of beta-lactam pharmacodynamics and interpatient and intrapatient variability in pharmacokinetics, the usefulness of therapeutic drug monitoring (TDM) is becoming increasingly clear. However, little research has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81850fd960eb7b0571f2b1401682b847
https://doi.org/10.1097/ftd.0000000000000937
https://doi.org/10.1097/ftd.0000000000000937
Autor:
Nicole G. M. Hunfeld, Henrik Endeman, Tim M J Ewoldt, Suzanne Polinder, Diederik Gommers, Anouk E. Muller, Alan Abdulla, Birgit C. P. Koch
Publikováno v:
Therapeutic Drug Monitoring
Therapeutic Drug Monitoring, 44(1), 224-229. Lippincott Williams & Wilkins
Therapeutic Drug Monitoring, 44(1), 224-229. Lippincott Williams & Wilkins
Supplemental Digital Content is Available in the Text.
Background: Optimizing beta-lactam antibiotic treatment is a promising method to reduce the length of intensive care unit (ICU) stay and therefore reduce ICU costs. We used data from the EXP
Background: Optimizing beta-lactam antibiotic treatment is a promising method to reduce the length of intensive care unit (ICU) stay and therefore reduce ICU costs. We used data from the EXP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79faf3a8d0c0873d681b43dba967d690
http://europepmc.org/articles/PMC8746885
http://europepmc.org/articles/PMC8746885
Autor:
Soma, Bahmany, Alan, Abdulla, Tim M J, Ewoldt, Philip L, Oehlers, Brenda C M, de Winter, Birgit C P, Koch
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 219
Quantification of beta-lactam antibiotics can be performed by using liquid chromatography in combination with tandem mass spectrometry (MS/MS) or ultraviolet (UV) detection. Since beta-lactam antibiotics are known as highly polar analytes, using stan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2475c245e3aa36ffffaa33a8bc8de36e
https://pubmed.ncbi.nlm.nih.gov/35772234
https://pubmed.ncbi.nlm.nih.gov/35772234
Autor:
Soma Bahmany, Diederik Gommers, Birgit C. P. Koch, Alan Abdulla, Nicole G. M. Hunfeld, Annemieke Dijkstra, Anouk E. Muller, Teun van Gelder, Henrik Endeman, Tim M J Ewoldt
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-12 (2020)
Critical Care
Critical Care, 24(1):558. BioMed Central Ltd.
Critical Care, 24(1). BMC
Critical Care
Critical Care, 24(1):558. BioMed Central Ltd.
Critical Care, 24(1). BMC
Background Early and appropriate antibiotic dosing is associated with improved clinical outcomes in critically ill patients, yet target attainment remains a challenge. Traditional antibiotic dosing is not suitable in critically ill patients, since th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91cddfbfedc977a5f350de1956f3c07
http://link.springer.com/article/10.1186/s13054-020-03272-z
http://link.springer.com/article/10.1186/s13054-020-03272-z