Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tim Korbut"'
Autor:
David A Proia, Kevin P Foley, Tim Korbut, Jim Sang, Don Smith, Richard C Bates, Yuan Liu, Alex F Rosenberg, Dan Zhou, Keizo Koya, James Barsoum, Ronald K Blackman
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18552 (2011)
There is accumulating evidence that dysregulated JAK signaling occurs in a wide variety of cancer types. In particular, mutations in JAK2 can result in the constitutive activation of STAT transcription factors and lead to oncogenic growth. JAK kinase
Externí odkaz:
https://doaj.org/article/5f8979a9202f493f95717a8dd14439d5
Autor:
Andrew Sonderfan, Josephine Ye, Tim Korbut, Dan Zhou, Kevin Foley, Mei Zhang, Hao Li, Chris Borella, Jun Jiang, James Barsoum, Xuemei Zhang, Yaming Wu, Jim Sang
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 343(2)
Vascular disrupting agents (VDAs) are an emerging class of therapeutics targeting the existing vascular network of solid tumors. However, their clinical progression has been hampered because of limited single-agent efficacy, primarily caused by the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157571b0fcbc8b9916f8876228414f15
https://pubmed.ncbi.nlm.nih.gov/22837008
https://pubmed.ncbi.nlm.nih.gov/22837008
Autor:
Alexander F. Rosenberg, Ronald K. Blackman, Kevin Foley, Tim Korbut, David A. Proia, Dan Zhou, Don Smith, Keizo Koya, James Barsoum, Yuan Liu, Jim Sang, Richard C. Bates
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 4, p e18552 (2011)
PLoS ONE, Vol 6, Iss 4, p e18552 (2011)
There is accumulating evidence that dysregulated JAK signaling occurs in a wide variety of cancer types. In particular, mutations in JAK2 can result in the constitutive activation of STAT transcription factors and lead to oncogenic growth. JAK kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55abf6305f23bd2c4ccf9670ed6d063a
https://doi.org/10.1371/journal.pone.0018552
https://doi.org/10.1371/journal.pone.0018552
Publikováno v:
Cancer Research. 71:2677-2677
Introduction: Radiation is accepted as an important standard therapy for locally unresectable cancers, and as such is given to approximately 60% of cancer patients. However, radio-resistance and repair of sublethal radiation damage can limit its effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc34f0329a5265922561c824c26ace42
https://doi.org/10.1158/1538-7445.am2011-2677
https://doi.org/10.1158/1538-7445.am2011-2677
Autor:
Ronald K. Blackman, David A. Proia, Keizo Koya, Alexander F. Rosenberg, Donald Smith, Chaohua Zhang, Jim Sang, Kevin Foley, Tim Korbut
Publikováno v:
Cancer Research. 70:2640-2640
Heat Shock Protein 90 (Hsp90) is a molecular chaperone that mediates the post-translational stability of its protein substrates (“client proteins”). Cancer cells are particularly sensitive to Hsp90 inhibition because many client proteins play cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::403f722d653a75bdf49ee3750e511579
https://doi.org/10.1158/1538-7445.am10-2640
https://doi.org/10.1158/1538-7445.am10-2640
Autor:
Luisa Shin Ogawa, Kevin Foley, Haili Zhang, Noriaki Tatsuta, Jim Sang, Weiwen Ying, Takayo Inoue, Ronald K. Blackman, Yu Chen, Chaohua Zhang, David A. Proia, Tim Korbut, Keizo Koya, Donald Smith, John Chen
Publikováno v:
Cancer Research. 70:2637-2637
BACKGROUND: Heat shock protein 90 (Hsp90) is a molecular chaperone that regulates the folding, stability and activity of many kinases and signal transduction proteins that are critical for the proliferation and survival of cancer cells. These Hsp90 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cff427da9635589cae22d7c8b5443962
https://doi.org/10.1158/1538-7445.am10-2637
https://doi.org/10.1158/1538-7445.am10-2637
Autor:
Chaohua Zhang, Luisa Shin Ogawa, Takayo Inoue, Donald L. Smith, Noriaki Tatsuta, David James, Shaoguang Li, Shijie Zhang, Jane Kepros, Dinesh Chimmanamada, Tim Korbut, Jim Sang, James Barsoum, Weiwen Ying, Cong Peng, Kevin Foley, Teresa Przewloka, Zhenjian Du, Haili Zhang, Chin-Yu Yang, David A. Proia, Ronald K. Blackman, Suqin He
Publikováno v:
Molecular Cancer Therapeutics. 8:B199-B199
Heat shock protein 90 (Hsp90) is a molecular chaperone that regulates the post-translational folding of its protein substrates (“client proteins”). Cancer cells contain elevated levels of active Hsp90 and, because many client proteins play critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91829693fc79f905dc421f127fbef757
https://doi.org/10.1158/1535-7163.targ-09-b199
https://doi.org/10.1158/1535-7163.targ-09-b199
Autor:
Don Smith, Takeshi Shimamura, Jim Sang, Takayo Inoue, Christa L. Borgman, Weiwen Ying, James Barsoum, Tim Korbut, Luisa Shin Ogawa, Noriaki Tatsuta, David A. Proia, Chaohua Zhang, Geoffrey I. Shapiro, Ron K. Blackman, Haili Zhang, Kevin Foley
Publikováno v:
Molecular Cancer Therapeutics. 8:C91-C91
Background: Heat shock protein 90 (Hsp90) is a molecular chaperone that is required for the stability and function of many important signal transduction proteins that regulate the growth of cancer cells. Hsp90 inhibition results in ubiquitination and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::998d0bfab3e557b572eadf52446203f2
https://doi.org/10.1158/1535-7163.targ-09-c91
https://doi.org/10.1158/1535-7163.targ-09-c91