Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces

Autor: Adrian Fischer, Tim Koopmans, Pushkar Ramesh, Simon Christ, Maximilian Strunz, Juliane Wannemacher, Michaela Aichler, Annette Feuchtinger, Axel Walch, Meshal Ansari, Fabian J. Theis, Kenji Schorpp, Kamyar Hadian, Philipp-Alexander Neumann, Herbert B. Schiller, Yuval Rinkevich

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Surgical adhesions are organ-joining bands of scar tissue that remain clinically untreatable. Here, the authors show that adhesions are formed through expansive mesothelial membrane bridges, and that blocking these with small molecules prevents forma

Externí odkaz: https://doaj.org/article/14eab87dfd66492c8aa804c34480c9bf

Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration

Autor: Phong D. Nguyen, Iris Gooijers, Giulia Campostrini, Arie O. Verkerk, Hessel Honkoop, Mara Bouwman, Dennis E. M. de Bakker, Tim Koopmans, Aryan Vink, Gerda E. M. Lamers, Avraham Shakked, Jonas Mars, Aat A. Mulder, Sonja Chocron, Kerstin Bartscherer, Eldad Tzahor, Christine L. Mummery, Teun P. de Boer, Milena Bellin, Jeroen Bakkers

Publikováno v: Science, 380(6646), 758-764. American Association for the Advancement of Science

Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving cardiomyocytes have been extensively studied, little is known about the mechanisms that control proli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943bee9c72057afcf68114b824ca5b6c
https://doi.org/10.1126/science.abo6718

Courts and Political Institutions : A Comparative View

Autor: Tim Koopmans

The frontier between'law'and'politics'is not always clear-cut. A large area exists where courts operate, but where governments and parliaments also make decisions. Tim Koopmans compares the way American, British, French and German law and politics de

Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)

Autor: Jochem Boeter, Kerstin Bartscherer, Danielle Versteeg, Olympia Ekaterini Psathaki, Eva van Rooij, Henriette van Beijnum, Tim Koopmans, Divyanshu Malhotra, Antonio Tomasso, Elke F. Roovers

Publikováno v: NPJ Regenerative Medicine
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-16 (2021)
NPJ Regenerative medicine, 6(1). Nature Publishing Group
npj Regenerative Medicine

Ischemic heart disease and by extension myocardial infarction is the primary cause of death worldwide, warranting regenerative therapies to restore heart function. Current models of natural heart regeneration are restricted in that they are not of ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3ef3384226f652b8a647b6f4a5cc8a
http://europepmc.org/articles/PMC8599451

Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation

Autor: Maarten van den Berge, Tim Koopmans, Mark H. Menzen, Victor Guryev, Ron Smits, Gerard H. Koppelman, Reinoud Gosens, I. Sophie T. Bos, Laura Hesse, Kuldeep Kumawat, Elvira R M Bakker, Martijn C. Nawijn

Publikováno v: Scientific Reports
Scientific Reports, 10(1):6754. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)

Asthma is a heterogeneous disease characterized by chronic inflammation and structural changes in the airways. The airway smooth muscle (ASM) is responsible for airway narrowing and an important source of inflammatory mediators. We and others have pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed7ca186f3b0f890f4a31d7f8152189
https://doi.org/10.1038/s41598-020-63741-x