Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tim Keuler"'
Publikováno v:
ACS Omega, Vol 7, Iss 9, Pp 8158-8162 (2022)
Externí odkaz:
https://doaj.org/article/ad32543943bd472c8256563efd77a977
Autor:
Tim Keuler, Karl Gatterdam, Anil Akbal, Marta Lovotti, Michael Marleaux, Matthias Geyer, Eicke Latz, Michael Gütschow
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Extracellular signals drive the nucleation of the NLRP3 inflammasome which leads to the release of cytokines and causes inflammatory events. Hence, the inflammasome has gained enormous momentum in biomedical basic research. The detailed mechanisms of
Externí odkaz:
https://doaj.org/article/060eff53c04e4d01a5529a0937ec15ac
Publikováno v:
Bioorganic Chemistry. 138:106574
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dedf78bfb593b36b50253ff9c30ef3e8
https://doi.org/10.1016/j.bioorg.2023.106574
https://doi.org/10.1016/j.bioorg.2023.106574
Autor:
Tim Keuler, Beate König, Nico Bückreiß, Fabian B. Kraft, Philipp König, Linda Schäker-Hübner, Christian Steinebach, Gerd Bendas, Michael Gütschow, Finn K. Hansen
Publikováno v:
Chemical Communications. 58:11087-11090
The targeted degradation of histone deacetylase 6 (HDAC6) by heterobifunctional degraders constitutes a promising approach to treat HDAC6-driven diseases. Previous HDAC6 selective degraders utilised a hydroxamic acid as a zinc-binding group (ZBG) whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b75b15bd78c147a2b9c09ce7c7113e
https://doi.org/10.1039/d2cc03712b
https://doi.org/10.1039/d2cc03712b
Autor:
Robert Kuchta, Christopher Heim, Alexander Herrmann, Samuel Maiwald, Yuen Lam Dora Ng, Izidor Sosič, Tim Keuler, Jan Krönke, Michael Gütschow, Marcus D. Hartmann, Christian Steinebach
Publikováno v:
RSC chemical biology, 2023.
The Petasis borono-Mannich reaction was employed for an alternative entry towards three-branched cereblon ligands. Such compounds are capabable of making multiple interactions with the protein surface and possess a suitable linker exit vector. The hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa984d3da083d945a230ab521424c1f
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=144171
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=144171
Autor:
Tim Keuler, Carina Lemke, Paul W. Elsinghorst, Isabel Iriepa, Mourad Chioua, María Angeles Martínez-Grau, Christopher D. Beadle, Tatiana Vetman, Francisco López-Muñoz, Timo Wille, Ulrike Bartz, Winnie Deuther-Conrad, José Marco-Contelles, Michael Gütschow
Publikováno v:
ACS Pharmacology & Translational Science 5(2022)11, 1097-1108
The multifactorial nature of Alzheimer's disease necessitates the development of agents able to interfere with different relevant targets. A series of 22 tailored chromanones was conceptualized, synthesized, and subjected to biological evaluation. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1034b7756033b6074cc7a24b962035bd
http://hdl.handle.net/10261/295421
http://hdl.handle.net/10261/295421
Autor:
Tim Keuler, Vigneshwaran Namasivayam, Michael Gütschow, Christa E. Müller, Sang-Yong Lee, Thanigaimalai Pillaiyar, Katharina Sylvester, Laura Schäkel, Julie Pelletier, Jean Sévigny, Markus Pietsch, Salahuddin Mirza
Publikováno v:
Archiv der PharmazieREFERENCES. 354(12)
The antithrombotic prodrugs ticlopidine and clopidogrel are thienotetrahydro-pyridine derivatives that are metabolized in the liver to produce thiols that irreversibly block adenosine diphosphate (ADP)-activated P2Y12 receptors on thrombocytes. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a324c29e0e7ca7d6821d62a3502f1b
https://pubmed.ncbi.nlm.nih.gov/34697820
https://pubmed.ncbi.nlm.nih.gov/34697820
Autor:
Michael Gütschow, Michaela Hympánová, Gregor Schnakenburg, Andreas Schneider, Jim Küppers, Tim Keuler
Publikováno v:
Synthesis. 51:1961-1968
The modification of amino acids leads to valuable building blocks for the synthesis of bioactive compounds. By keeping the amino group protected, the carboxylic acid functionality can be converted in two steps into an imidazole moiety via a Davidson-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcb7cabd065ace3fb719755d603d5b13
https://doi.org/10.1055/s-0037-1612084
https://doi.org/10.1055/s-0037-1612084
Autor:
Marta Lovotti, Tim Keuler, Michael Gütschow, Matthias Geyer, Anil Akbal, Karl Gatterdam, Michael Marleaux, Eicke Latz
Publikováno v:
Frontiers in Chemistry
Frontiers in Chemistry, Vol 9 (2021)
Frontiers in Chemistry, Vol 9 (2021)
Extracellular signals drive the nucleation of the NLRP3 inflammasome which leads to the release of cytokines and causes inflammatory events. Hence, the inflammasome has gained enormous momentum in biomedical basic research. The detailed mechanisms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4bedbbfbd06f54c6f46c10c60122842
https://doi.org/10.3389/fchem.2021.642273
https://doi.org/10.3389/fchem.2021.642273