Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Tim Kacprowski"'
Autor:
Hannah Benedictine Maier, Alexandra Neyazi, Gabriel L. Bundies, Fiona Meyer-Bockenkamp, Stefan Bleich, Hansi Pathak, Yvonne Ziert, Barbara Neuhaus, Franz-Josef Müller, Iris Pollmann, Thomas Illig, Stefanie Mücke, Meike Müller, Brinja Kira Möller, Steffen Oeltze-Jafra, Tim Kacprowski, Jan Voges, Fabian Müntefering, Josef Scheiber, Andreas Reif, Mareike Aichholzer, Christine Reif-Leonhard, Maren Schmidt-Kassow, Ulrich Hegerl, Hanna Reich, Stefan Unterecker, Heike Weber, Jürgen Deckert, Nicole Bössel-Debbert, Hans J. Grabe, Michael Lucht, Helge Frieling
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Brain-derived neurotrophic factor (BDNF) is essential for antidepressant treatment of major depressive disorder (MDD). Our repeated studies suggest that DNA methylation of a specific CpG site in the promoter region of exon IV of t
Externí odkaz:
https://doaj.org/article/55ea2c6790ba48b2a005ed3270692acc
Publikováno v:
BMC Medical Ethics, Vol 24, Iss 1, Pp 1-9 (2023)
Abstract Background Healthcare providers have to make ethically complex clinical decisions which may be a source of stress. Researchers have recently introduced Artificial Intelligence (AI)-based applications to assist in clinical ethical decision-ma
Externí odkaz:
https://doaj.org/article/4bd0dae3b0d9402fae73ba54055227ed
Autor:
Sepideh Sadegh, James Skelton, Elisa Anastasi, Andreas Maier, Klaudia Adamowicz, Anna Möller, Nils M. Kriege, Jaanika Kronberg, Toomas Haller, Tim Kacprowski, Anil Wipat, Jan Baumbach, David B. Blumenthal
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Large-scale disease-association data are widely used for pathomechanism mining, even if disease definitions used for annotation are mostly phenotype-based. Here, the authors show that this bias can lead to a blurred view on disease mechanisms, highli
Externí odkaz:
https://doaj.org/article/f94efe6e0688493fa30f8c9113b32eb9
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 780-795 (2023)
Molecular interaction networks lay the foundation for studying how biological functions are controlled by the complex interplay of genes and proteins. Investigating perturbed processes using biological networks has been instrumental in uncovering mec
Externí odkaz:
https://doaj.org/article/697a5d5aa0de4033a0c14a4c40b30a15
Autor:
Julian Matschinske, Julian Späth, Mohammad Bakhtiari, Niklas Probul, Mohammad Mahdi Kazemi Majdabadi, Reza Nasirigerdeh, Reihaneh Torkzadehmahani, Anne Hartebrodt, Balazs-Attila Orban, Sándor-József Fejér, Olga Zolotareva, Supratim Das, Linda Baumbach, Josch K Pauling, Olivera Tomašević, Béla Bihari, Marcus Bloice, Nina C Donner, Walid Fdhila, Tobias Frisch, Anne-Christin Hauschild, Dominik Heider, Andreas Holzinger, Walter Hötzendorfer, Jan Hospes, Tim Kacprowski, Markus Kastelitz, Markus List, Rudolf Mayer, Mónika Moga, Heimo Müller, Anastasia Pustozerova, Richard Röttger, Christina C Saak, Anna Saranti, Harald H H W Schmidt, Christof Tschohl, Nina K Wenke, Jan Baumbach
Publikováno v:
Journal of Medical Internet Research, Vol 25, p e42621 (2023)
BackgroundMachine learning and artificial intelligence have shown promising results in many areas and are driven by the increasing amount of available data. However, these data are often distributed across different institutions and cannot be easily
Externí odkaz:
https://doaj.org/article/291c28483a50402ea7629f652a71d7c5
Autor:
Zsolt Illes, Malene Møller Jørgensen, Rikke Bæk, Lisa-Marie Bente, Jørgen T. Lauridsen, Kirsten H. Hyrlov, Christopher Aboo, Jan Baumbach, Tim Kacprowski, Francois Cotton, Charles R. G. Guttmann, Allan Stensballe
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3170 (2023)
Background: Blood–barrier (BBB) breakdown and active inflammation are hallmarks of relapsing multiple sclerosis (RMS), but the molecular events contributing to the development of new lesions are not well explored. Leaky endothelial junctions are as
Externí odkaz:
https://doaj.org/article/4f82c6359f3b4f68a734ecf8103bdba8
Autor:
Maria L. Elkjaer, Lukas Simon, Tobias Frisch, Lisa-Marie Bente, Tim Kacprowski, Mads Thomassen, Richard Reynolds, Jan Baumbach, Richard Röttger, Zsolt Illes
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Infectious agents have been long considered to play a role in the pathogenesis of neurological diseases as part of the interaction between genetic susceptibility and the environment. The role of bacteria in CNS autoimmunity has also been highlighted
Externí odkaz:
https://doaj.org/article/8d100ff80cf640a58e690695f80fb584
Autor:
Reza Nasirigerdeh, Reihaneh Torkzadehmahani, Julian Matschinske, Tobias Frisch, Markus List, Julian Späth, Stefan Weiss, Uwe Völker, Esa Pitkänen, Dominik Heider, Nina Kerstin Wenke, Georgios Kaissis, Daniel Rueckert, Tim Kacprowski, Jan Baumbach
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-24 (2022)
Abstract Meta-analysis has been established as an effective approach to combining summary statistics of several genome-wide association studies (GWAS). However, the accuracy of meta-analysis can be attenuated in the presence of cross-study heterogene
Externí odkaz:
https://doaj.org/article/3d896a9b432e4884b5b3e0f48567d7c7
Autor:
Zakaria Louadi, Maria L. Elkjaer, Melissa Klug, Chit Tong Lio, Amit Fenn, Zsolt Illes, Dario Bongiovanni, Jan Baumbach, Tim Kacprowski, Markus List, Olga Tsoy
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)
Abstract Alternative splicing (AS) is an important aspect of gene regulation. Nevertheless, its role in molecular processes and pathobiology is far from understood. A roadblock is that tools for the functional analysis of AS-set events are lacking. T
Externí odkaz:
https://doaj.org/article/4c0fecaa3f3d44588d58bb08e10ab366
Autor:
Fabian Stögbauer, Barbara Geß, Christine Brambs, Manuela Lautizi, Tim Kacprowski, Iordanis Ourailidis, Holger Bronger, Marion Kiechle, Aurelia Noske, Gisela Keller, Moritz Jesinghaus, Christopher Poremba, Wilko Weichert, Melanie Boxberg
Publikováno v:
Cancers, Vol 15, Iss 15, p 3832 (2023)
The molecular characterization of endometrial endometrioid adenocarcinomas has provided major advances in its prognostic stratification. However, risk assessment of microsatellite instability (MSI) and copy-number (CN)-low cases remains a challenge.
Externí odkaz:
https://doaj.org/article/8c9f10bc21774cdfb770e89b4290cc9a