Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Tim J.B. Gray"'
Publikováno v:
Toxicology. 118:115-127
Using 1- and 2-aminonaphthalene as model substrates, we investigated the effect of insertion of a second amino group on mutagenicity, binding to the cytosolic Ah receptor and CYP1A inducibility, and the effects were compared to those elicited by 3,3'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95804e3fcc67f22dbfbe6db75c5920e0
https://doi.org/10.1016/s0300-483x(96)03590-1
https://doi.org/10.1016/s0300-483x(96)03590-1
Autor:
Jeremy K. Nicholson, Tim J.B. Gray, Maria L. Anthony, Peter C. R. McDowell, Melanie Blackmore
Publikováno v:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 1(1)
Cell cultures are increasingly used in the evaluation of chemically-induced nephrotoxicity. The utili of renal cell culture systems in toxicology would be improved, however, if better characterized and more specific markers of toxicity were available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dde36ba8a39677219ec7c1ff1cfdbcf
https://pubmed.ncbi.nlm.nih.gov/23888892
https://pubmed.ncbi.nlm.nih.gov/23888892
Autor:
A.J. Spencer, Ernest S. Harpur, Stephen J. Byard, Tim J.B. Gray, Frank W. Bonner, Susan Halligan
Publikováno v:
Toxicology Letters. 81:15-21
Male New Zealand White rabbits received a single intravenous injection of 125 mg/kg cephaloridine, 500 mg/kg cefoperazone or 1000 mg/kg cephalothin. Histological examination of kidneys at 48 h post-dose confirmed the presence of bilateral necrosis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e70b006a611571dcb3e44cb7efdd630
https://doi.org/10.1016/0378-4274(95)03399-8
https://doi.org/10.1016/0378-4274(95)03399-8
Autor:
Tim J.B. Gray, Gregorius Lukito, Ni Yicheng, Albert Baert, Carine Petré, Guy Marchal, Derek Grant
Publikováno v:
Academic Radiology. 2:300-305
Rationale and Objectives. It is known that manganese dipyridoxal diphosphate (Mn-DPDP) causes persisting liver enhancement in cholestatic rats, that free Mn ++ plus bilirubin induces intrahepatic cholestasis, and that free Mn ++ is released in vivo a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a8852c3b3db891d408a566ccac1777
https://doi.org/10.1016/s1076-6332(05)80188-6
https://doi.org/10.1016/s1076-6332(05)80188-6
Publikováno v:
Toxicology in Vitro. 7:605-614
Rat hepatocytes were cultured for 70 hr with a series of 15 chemicals (including herbicides and derivatives, hypolipidaemic agents and other compounds) and the effects on some enzyme activities were determined. All of the compounds produced concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8f989509dcb447050d18ae22852c73
https://doi.org/10.1016/0887-2333(93)90094-l
https://doi.org/10.1016/0887-2333(93)90094-l
Publikováno v:
Chemical Research in Toxicology. 6:535-541
A study has been undertaken to identify the properties of 2-(acetylamino)fluorene which render it carcinogenic, in contrast to the 4-isomer, the carcinogenic potential of which is, at best, very weak. Compared to the 4-isomer, 2-(acetylamino)fluorene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bddb2854c6bd1dd5ee12b8a9c6678eb
https://doi.org/10.1021/tx00034a023
https://doi.org/10.1021/tx00034a023
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 8(4)
Nephrotoxin-induced damage to cultured kidney cells (LLC-PK 1 ) was investigated using assays of general cytotoxicity (neutral red uptake) and of functional impairment (glucose accumulation). The latter correctly ranked both the cephalosporin and ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8abb7be359d4c0f50932239ac63b965
https://pubmed.ncbi.nlm.nih.gov/20693008
https://pubmed.ncbi.nlm.nih.gov/20693008
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 11(5)
The majority of in vitro toxicology studies employing precision-cut rat renal slices are carried out using simple incubation systems over relatively short periods of time (usually up to 8 hr). We aimed to develop a system for longer-term (up to 24 hr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10975921f92598ea01c55244ee752db1
https://pubmed.ncbi.nlm.nih.gov/20654377
https://pubmed.ncbi.nlm.nih.gov/20654377
Publikováno v:
Toxicology in Vitro. 8:601-603
Scanning electron microscopy was used to study cephaloridine and gentamicin-induced renal cell injury in vitro. Exposure of renal proximal tubular cells to these toxicants produced changes in cell surface morphology that occurred at concentrations si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e993460c4b8854154baccd769c4ec33
https://doi.org/10.1016/0887-2333(94)90026-4
https://doi.org/10.1016/0887-2333(94)90026-4
Publikováno v:
Toxicology. 175(1-3)
The aim of this study was to examine the effect of haloalkene S-cysteine conjugates on cytosolic free Ca(2+) levels in renal epithelial cells using digital imaging fluorescence microscopy (DIFM). S-(1,2,3,4,4-pentachloro-1,3,-butadienyl)-L-cysteine (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251c3e203527d9d4d11025a8e9667d09
https://pubmed.ncbi.nlm.nih.gov/12049843
https://pubmed.ncbi.nlm.nih.gov/12049843