Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Tim J. Allison"'
Autor:
Beth Pietrak, Hemaka A. Rajapakse, Dennis Colussi, Paul Zuck, Hong Zhu, Kristen L.G. Jones, Adam J. Simon, Samuel L. Graham, Shawn J. Stachel, M. Katharine Holloway, Diane M. Rush, Joseph P. Vacca, Amy S. Espeseth, Tim J. Allison, Ming-Tain Lai, Craig A. Coburn, Abigail Wolfe, Sanjeev Munshi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2977-2980
We have developed a novel series of heteroaromatic BACE-1 inhibitors. These inhibitors interact with the enzyme in a unique fashion that allows for potent binding in a non-traditional paradigm. In addition to the elucidation of their binding profile,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155a8b5e1b3ae3aa336bc6e7564cf5aa
https://doi.org/10.1016/j.bmcl.2009.04.033
https://doi.org/10.1016/j.bmcl.2009.04.033
Autor:
Ashley Nomland, Dennis Colussi, Tim J. Allison, Samuel L. Graham, M. Katharine Holloway, Pablo De Leon, Hemaka A. Rajapakse, Hong Zhu, Sharie J. Haugabook, Sanjeev Munshi, Shawn J. Stachel, Ivory D. Hills, Beth Pietrak, Dawn Toolan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4993-4995
During our ongoing efforts to develop a small molecule inhibitor targeting the β-amyloid cleaving enzyme (BACE-1), we discovered a class of compounds bearing an aminoimidazole motif. Initial optimization led to potent compounds that have high Pgp ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb21d58ec67fa0c78f7af660cdc17a4c
https://doi.org/10.1016/j.bmcl.2009.07.071
https://doi.org/10.1016/j.bmcl.2009.07.071