Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Tim J M Welting"'
Autor:
Guus G H van den Akker, Don A M Surtel, Andy Cremers, Stephen M Richardson, Judith A Hoyland, Lodewijk W van Rhijn, Jan Willem Voncken, Tim J M Welting
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0144497 (2016)
INTRODUCTION:Loss of annulus fibrosus (AF) integrity predisposes to disc herniation and is associated with IVD degeneration. Successful implementation of biomedical intervention therapy requires in-depth knowledge of IVD cell biology. We recently gen
Externí odkaz:
https://doaj.org/article/d9148fedbde842ed99b8cd0e3991ed20
Autor:
Marjolein M J Caron, Pieter J Emans, Kathleen Sanen, Don A M Surtel, Andy Cremers, Daan Ophelders, Lodewijk W van Rhijn, Tim J M Welting
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153162 (2016)
NSAIDs are used to relieve pain and decrease inflammation by inhibition of cyclooxygenase (COX)-catalyzed prostaglandin (PG) synthesis. PGs are fatty acid mediators involved in cartilage homeostasis, however the action of their synthesizing COX-enzym
Externí odkaz:
https://doaj.org/article/1a2e8a97ef1042ffbace493ca6afa60f
Autor:
Frank Spaapen, Guus G H van den Akker, Marjolein M J Caron, Peggy Prickaerts, Celine Rofel, Vivian E H Dahlmans, Don A M Surtel, Yvette Paulis, Finja Schweizer, Tim J M Welting, Lars M Eijssen, Jan Willem Voncken
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58083 (2013)
Initiation of and progression through chondrogenesis is driven by changes in the cellular microenvironment. At the onset of chondrogenesis, resting mesenchymal stem cells are mobilized in vivo and a complex, step-wise chondrogenic differentiation pro
Externí odkaz:
https://doaj.org/article/2c6e4bd2e4f0422b9f5b061c303a10be
Autor:
Marjolein M J Caron, Pieter J Emans, Don A M Surtel, Andy Cremers, Jan Willem Voncken, Tim J M Welting, Lodewijk W van Rhijn
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33467 (2012)
BACKGROUND: NF-κB/p65 has been reported to be involved in regulation of chondrogenic differentiation. However, its function in relation to key chondrogenic factor Sox9 and onset of chondrogenesis during endochondral ossification is poorly understood
Externí odkaz:
https://doaj.org/article/f70a65961d1442f0b8cacf084529248a
Autor:
Yalda A. Kharaz, Danae E. Zamboulis, Yongxiang Fang, Tim J. M. Welting, Mandy J. Peffers, Eithne J. Comerford
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: The anterior cruciate ligament (ACL) is susceptible to degeneration, resulting in joint pain, reduced mobility, and osteoarthritis development. There is currently a paucity of knowledge on how anterior cruciate ligament degeneration and
Externí odkaz:
https://doaj.org/article/37bd6d47f9c741b8bbbcbfe401f985d4
Autor:
Katrin Agnes Muenzebrock, Fiona Y. W. Ho, Adriano P. Pontes, Carla Jorquera-Cordero, Lizette Utomo, Joao Pedro Garcia, Paul C. Willems, Tim J. M. Welting, Jaap Rip, Laura B. Creemers
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 438 (2024)
Chronic lower back pain caused by intervertebral disc degeneration and osteoarthritis (OA) are highly prevalent chronic diseases. Although pain management and surgery can alleviate symptoms, no disease-modifying treatments are available. mRNA deliver
Externí odkaz:
https://doaj.org/article/54e356b8756440688f3f72529fd672dd
Autor:
Ellen G. J. Ripmeester, Marjolein M. J. Caron, Guus G. H. van den Akker, Jessica Steijns, Don A. M. Surtel, Andy Cremers, Laura C. W. Peeters, Lodewijk W. van Rhijn, Tim J. M. Welting
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The fibrocartilage chondrocyte phenotype has been recognized to attribute to osteoarthritis (OA) development. These chondrocytes express genes related to unfavorable OA outcomes, emphasizing its importance in OA pathology. BMP7 is being expl
Externí odkaz:
https://doaj.org/article/01cfdb8fb7d54afe8a50c8e5b9da0ebe
Autor:
Panagiotis Balaskas, Katarzyna Goljanek-Whysall, Peter D. Clegg, Yongxiang Fang, Andy Cremers, Aibek Smagul, Tim J. M. Welting, Mandy J. Peffers
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1189 (2023)
Osteoarthritis is the most common degenerative joint disorder. MicroRNAs are gene expression regulators that act post-transcriptionally to control tissue homeostasis. Microarray analysis was undertaken in osteoarthritic intact, lesioned and young int
Externí odkaz:
https://doaj.org/article/1524c35eecee49269048b319151fb6a9
Autor:
Catarina Castanheira, Panagiotis Balaskas, Charlotte Falls, Yalda Ashraf-Kharaz, Peter Clegg, Kim Burke, Yongxiang Fang, Philip Dyer, Tim J. M. Welting, Mandy J. Peffers
Publikováno v:
BMC Veterinary Research, Vol 17, Iss 1, Pp 1-12 (2021)
Abstract Background Osteoarthritis remains one of the greatest causes of morbidity and mortality in the equine population. The inability to detect pre-clinical changes in osteoarthritis has been a significant impediment to the development of effectiv
Externí odkaz:
https://doaj.org/article/42deb3c221b0429a837b62a64e001690
Autor:
Ellen G. J. Ripmeester, Tim J. M. Welting, Guus G. H. van den Akker, Don A. M. Surtel, Jessica S. J. Steijns, Andy Cremers, Lodewijk W. van Rhijn, Marjolein M. J. Caron
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
BMP7 is a morphogen capable of counteracting the OA chondrocyte hypertrophic phenotype via NKX3-2. NKX3-2 represses expression of RUNX2, an important transcription factor for chondrocyte hypertrophy. Since RUNX2 has previously been described as an in
Externí odkaz:
https://doaj.org/article/68066cf15959463cbf6882b07c7b2fb3