Exploring the zoonotic potential of Mycobacterium avium subspecies paratuberculosis through comparative genomics.

Autor: James W Wynne, Tim J Bull, Torsten Seemann, Dieter M Bulach, Josef Wagner, Carl D Kirkwood, Wojtek P Michalski

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e22171 (2011)

A comparative genomics approach was utilised to compare the genomes of Mycobacterium avium subspecies paratuberculosis (MAP) isolated from early onset paediatric Crohn's disease (CD) patients as well as Johne's diseased animals. Draft genome sequence

Externí odkaz: https://doaj.org/article/2664c8fcd2f1473c9dcacccf84be0f6b

Cytokine expression in subjects with Mycobacterium avium ssp. paratuberculosis positive blood cultures and a meta-analysis of cytokine expression in Crohn’s disease

Autor: J. Todd Kuenstner, Qiang Xu, Tim J. Bull, Antonio C. G. Foddai, Irene R. Grant, Saleh A. Naser, Raghava Potula, Peilin Zhang, Ira Shafran, Serhat Emre Akhanli, Svetlana Khaiboullina, Russell Kruzelock

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Objectives1) Culture Mycobacterium avium ssp. paratuberculosis (MAP)from blood, 2) assess infection persistence, 3) determine Crohn’s disease (CD) cytokine expression, 4) compare CD cytokine expression to tuberculosis, and 5) perform a meta-analysi

Externí odkaz: https://doaj.org/article/ca62cd70a0e0441c8d776c8eaaa54a26

Discovery of Antimicrobial Peptides That Can Accelerate Culture Diagnostics of Slow-Growing Mycobacteria Including Mycobacterium tuberculosis

Autor: Kai Hilpert, Tulika Munshi, Paula M. López-Pérez, Joana Sequeira-Garcia, Sven Hofmann, Tim J. Bull

Publikováno v: Microorganisms, Vol 11, Iss 9, p 2225 (2023)

Antimicrobial peptides (AMPs) can directly kill Gram-positive bacteria, Gram-negative bacteria, mycobacteria, fungi, enveloped viruses, and parasites. At sublethal concentrations, some AMPs and also conventional antibiotics can stimulate bacterial re

Externí odkaz: https://doaj.org/article/6f820ea55f1747948c9663e5b7bdf627

Viable Mycobacterium avium subsp. paratuberculosis Colonizes Peripheral Blood of Inflammatory Bowel Disease Patients

Autor: Sarmento, Maria Manuela Estevinho, José Cabeda, Mafalda Santiago, Elisabete Machado, Ricardo Silva, Mary Duro, Inês Pita, Rui Morais, Guilherme Macedo, Tim J. Bull, Fernando Magro, Amélia

Publikováno v: Microorganisms; Volume 11; Issue 6; Pages: 1520

Pathobionts, particularly Mycobacterium avium subsp. paratuberculosis (MAP) and Escherichia coli isolates with adherence/invasive ability (AIEC) have been associated with inflammatory bowel disease (IBD), particularly Crohn’s disease (CD). This stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::d32f47fefe08a2348ab1ea822662c98a

Presence of Infection by Mycobacterium avium subsp. Paratuberculosis in the Blood of Patients with Crohn’s Disease and Control Subjects Shown by Multiple Laboratory Culture and Antibody Methods

Autor: Tim J. Bull, Horacio Bach, Raghava Potula, J. Todd Kuenstner, Daohai Yu, Xiaoning Lu, Ira Shafran, Peilin Zhang, Antonio Foddai, Irene R. Grant, Saleh A. Naser

Publikováno v: Microorganisms, Vol 8, Iss 2054, p 2054 (2020)
Kuenstner, J T, Potula, R, Bull, T J, Grant, I R, Foddai, A, Naser, S, Bach, H, Zhang, P, Yu, D, Lu, X & Shafran, I 2020, ' Presence of infection by Mycobacterium avium subsp. paratuberculosis in the blood of patients with Crohn’s Disease and control subjects shown by multiple laboratory culture and antibody methods ', Microorganisms, vol. 8, no. 12, pp. 2054 . https://doi.org/10.3390/microorganisms8122054
Microorganisms
Volume 8
Issue 12

Mycobacterium avium subspecies paratuberculosis (MAP) has long been suspected to be involved in the etiology of Crohn&rsquo
s disease (CD). An obligate intracellular pathogen, MAP persists and influences host macrophages. The primary goals of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37bcc190b1134b1072c16576acaedac0
https://www.mdpi.com/2076-2607/8/12/2054