Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Tim J, Grattan"'
Publikováno v:
Clinical Therapeutics. 28:1273-1278
The aim of this study was to determine the time to onset of pain relief from a single dose of a tablet formulation of paracetamol (acetaminophen) containing sodium bicarbonate (PSC).A single oral dose of PSC or placebo was randomly administered to pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5769920d70acdeea2e32d135579014
https://doi.org/10.1016/j.clinthera.2006.09.009
https://doi.org/10.1016/j.clinthera.2006.09.009
Publikováno v:
Drug Development and Industrial Pharmacy. 31:515-525
The purpose of this investigation was to study the dissolution behavior of paracetamol and ibuprofen in the presence of a range of selected potential excipients. First, a pH-solubility profile was generated for both drugs, and the effect of changing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb33314f5b256d003acff731f4f592c8
https://doi.org/10.1080/03639040500215784
https://doi.org/10.1080/03639040500215784
Autor:
Mohammad Reza Shiran, Tim J. Grattan, Geoffrey T. Tucker, R. Ayesh, Amin Rostami-Hodjegan, I. Burnett, A. Darby-Dowman
Publikováno v:
Drug Development and Industrial Pharmacy. 28:523-531
The primary objective of this four-way crossover study was to compare the concentration-time profile of paracetamol from a new rapidly absorbed paracetamol tablet containing sodium bicarbonate (PS) with a conventional paracetamol tablet (P), in a pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258e1de8c63348bfacdfc4171971f96a
https://doi.org/10.1081/ddc-120003448
https://doi.org/10.1081/ddc-120003448
Autor:
Kay Brune, Angelika Beisel, Gerd Kobal, Christian Mueller, Bertold Renner, Ulrike Werner, Geoff Clarke, Tim J. Grattan
The aim of this study was to determine the analgesic effect of acetaminophen compared to a combination of both caffeine and acetaminophen or caffeine alone using tonic and phasic pain stimulation. Twenty-four subjects were treated orally with 1000 mg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac36481feffa9381beb71af579cc68ad
https://opus4.kobv.de/opus4-fau/files/2947/renner_caffeine_4181.pdf
https://opus4.kobv.de/opus4-fau/files/2947/renner_caffeine_4181.pdf
Publikováno v:
International journal of pharmaceutics. 290(1-2)
The aim of this study was to examine the diffusion of commonly administered analgesics, ibuprofen and paracetamol, through gastric mucus. As ibuprofen and paracetamol are often formulated with alkalising excipients, or are commonly co-administered wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a79e311d20ad091cbebcfefef20ab0
https://pubmed.ncbi.nlm.nih.gov/15664140
https://pubmed.ncbi.nlm.nih.gov/15664140
Autor:
Kilian, Kelly, Bridget, O'Mahony, Blythe, Lindsay, Tamara, Jones, Tim J, Grattan, Amin, Rostami-Hodjegan, Howard N E, Stevens, Clive G, Wilson
Publikováno v:
Pharmaceutical research. 20(10)
To investigate the hypothesis that faster drug absorption from a new paracetamol formulation containing sodium bicarbonate compared to that from a conventional formulation results from a combination of enhanced gastric emptying and disintegration/dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::76ec1890f6b3d5547eddba748718bbe7
https://pubmed.ncbi.nlm.nih.gov/14620524
https://pubmed.ncbi.nlm.nih.gov/14620524
Autor:
Lance R. Shaw, William J. Irwin, Mohammad Reza Shiran, Geoffrey T. Tucker, Barbara R. Conway, Amin Rostami-Hodjegan, Tim J. Grattan
Publikováno v:
Drug development and industrial pharmacy. 28(5)
The objective of this study was to compare the in vitro dissolution profile of a new rapidly absorbed paracetamol tablet containing sodium bicarbonate (PS) with that of a conventional paracetamol tablet (P), and to relate these by deconvolution and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf942cc6ce0e4a795a8b2bccf1cd387
https://pubmed.ncbi.nlm.nih.gov/12098842
https://pubmed.ncbi.nlm.nih.gov/12098842