Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Tim Hunkapiller"'
Autor:
MaryEllen Ahearn, Joan Goverman, Thea Brabb, Angela Paez, Tim Hunkapiller, Valerie Mannikko, Cassie J Harrington, Craig Beeson
Publikováno v:
Immunity. 8:571-580
Experimental allergic encephalomyelitis (EAE) is induced by T cell–mediated immunity to central nervous system antigens. In H-2u mice, EAE is mediated primarily by T cells specific for residues 1–11 of myelin basic protein (MBP). We demonstrate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837050b7f8c04cea4cfc8d62e0cab226
https://doi.org/10.1016/s1074-7613(00)80562-2
https://doi.org/10.1016/s1074-7613(00)80562-2
Publikováno v:
Proceedings of the National Academy of Sciences. 91:1059-1063
Hidden Markov model (HMM) techniques are used to model families of biological sequences. A smooth and convergent algorithm is introduced to iteratively adapt the transition and emission parameters of the models from the examples in a given family. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48445ca624bf3e279835fe4629b7ae3e
https://doi.org/10.1073/pnas.91.3.1059
https://doi.org/10.1073/pnas.91.3.1059
Publikováno v:
Trends in Biotechnology. 10:19-22
The human genome initiative has provided the motivating force for launching sequencing projects suitable for testing various DNA-sequencing strategies, as well as motivating the development of mapping and sequencing technologies. In addition to proje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebba93b1a0de57e36cc517978f79456e
https://doi.org/10.1016/0167-7799(92)90161-n
https://doi.org/10.1016/0167-7799(92)90161-n
Publikováno v:
SSDBM
Molecular biology applications, like those of other scientific domains, need to store and view large amounts of specialized quantitative information. With the advent of high speed sequencing technology and considerable funding to "map" the genomes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47d0caa19ce58203d5ba72edb192640c
https://doi.org/10.1109/ssdm.1997.621191
https://doi.org/10.1109/ssdm.1997.621191
Autor:
David P. Yee, Tim Hunkapiller
The Human Genome Project was launched in the early 1990s to map, sequence, and study the function of genomes derived from humans and a number of model organisms such as mouse, rat, fruit fly, worm, yeast, and Escherichia coli. This ambitious project
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62d98166592a1f253bb3119cbe443798
https://doi.org/10.1093/oso/9780195119404.003.0017
https://doi.org/10.1093/oso/9780195119404.003.0017
Autor:
Max Robinson, David K. Yee, James D. Candlin, Tim Hunkapiller, Robert Mines, Eugene G. Shpaer
Publikováno v:
Genomics. 38(2)
To predict the functions of a possible protein product of any new or uncharacterized DNA sequence, it is important first to detect all significant similarities between the encoded amino acid sequence and any accumulated protein sequence data. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32397ad4519ac55f757bdf4d493f325a
https://pubmed.ncbi.nlm.nih.gov/8954800
https://pubmed.ncbi.nlm.nih.gov/8954800
Publisher Summary This chapter presents the current chemistries involved in the synthesis of dye-primer sets for use with the Applied Biosystems 373A automated DNA sequencer as well as reliable protocols for their utilization in enzymatic DNA sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31f84dd7c3359337fdc8444f763883a5
https://doi.org/10.1016/0076-6879(93)18013-3
https://doi.org/10.1016/0076-6879(93)18013-3
Autor:
Tim Hunkapiller, Leroy Hood
Publikováno v:
Bio/technology (Nature Publishing Company). 9(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f0433b8e6632e58262800dfd128af7
https://pubmed.ncbi.nlm.nih.gov/1367767
https://pubmed.ncbi.nlm.nih.gov/1367767
Publikováno v:
Science (New York, N.Y.). 254(5028)
DNA sequence analysis is a multistage process that includes the preparation of DNA, its fragmentation and base analysis, and the interpretation of the resulting sequence information. New technological advances have led to the automation of certain st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ef5f02f2f88000a368e90eb78360b5
https://pubmed.ncbi.nlm.nih.gov/1925562
https://pubmed.ncbi.nlm.nih.gov/1925562
Publikováno v:
Current opinion in biotechnology. 2(1)
The problems of large-scale sequencing are discussed, together with existing and future strategies, and the technology capable of achieving the goal of a productive, efficient process is reviewed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988bc77da85388b89e483354ae63527b
https://pubmed.ncbi.nlm.nih.gov/1367715
https://pubmed.ncbi.nlm.nih.gov/1367715