Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Tim Heuer"'
Autor:
Hangjun Zhan, Hong Xiao, Katherine Brown, Yvonne Franke, Bo Guan, Kevin Patrick Keegan, Michael Robert Cancilla, Rachel M. Kindt, Rajashekar K. Reddy, Changyou Chen, Juan J. Perez-Villar, Tim Heuer, Dianne Parry, Veeraswamy Manne, Carol O'Brien, Mark I. Cockett, Greg D Plowman, Kevin Fitzgerald, Petra Ross-Macdonald, Mark R. Lackner, Pamela M. Carroll, Michael Costa, Jae Moon Lee, Tak Hung, Heshani de Silva
Publikováno v:
Cancer Cell. 7:325-336
SummaryA chemical genetics approach identified a cellular target of several proapoptotic farnesyl transferase inhibitors (FTIs). Treatment with these FTIs caused p53-independent apoptosis in Caenorhabditis elegans, which was mimicked by knockdown of
Autor:
Joanna Waszczuk, Marina Fridlib, Doug Buckley, William McCulloch, Richard Crowley, Marie O'Farrell, Claudia Rubio, Katharine Grimmer, Julie Lai, George Kemble, Richard Benn Abegania Ventura, Tim Heuer
Publikováno v:
Cancer Research. 76:LB-214
TVB-2640 is an oral, first-in-class, selective and reversible inhibitor of fatty acid synthase (FASN) in Phase 1 testing in solid tumor patients (study 3V2640-CLIN-002). FASN is a central mediator of neoplastic lipogenesis and uniquely catalyzes the
Publikováno v:
Molecular Cancer Research. 14:A75-A75
Dysregulated expression of FASN is a central mediator of neoplastic lipogenesis. FASN catalyzes the production of palmitate, the building block of long chain fatty acids, providing a mechanism to convert glucose and other carbon sources into lipids n