Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Tim H. Parmley"'
Autor:
Tomoyo Kusuda, Yuko Shiroyama, Tim H. Parmley, Timothy J. O'Brien, Kazushi Shigemasa, Takashi Sawasaki, Tsuneo Fujii, Koso Ohama
Publikováno v:
Journal of the Society for Gynecologic Investigation. 8:179-185
We investigated the relationship between cyclin E mRNA overexpression and p53 protein accumulation in epithelial ovarian cancers. mRNA was isolated and cDNA was prepared from 36 epithelial ovarian tumors (three adenomas, three low malignant potential
Autor:
Yinxiang Wang, Lowell J. Underwood, Hirotoshi Tanimoto, Timothy J. O'Brien, Tim H. Parmley, Kazushi Shigemasa
Publikováno v:
Tumor Biology. 22:104-114
Proteases have been implicated in the extracellular modulation required for tumor growth and invasion. In an effort to categorize those proteases contributing to ovarian carcinoma progression, we have utilized redundant primers to conserved amino aci
Autor:
Timothy J. O'Brien, Kazushi Shigemasa, Lowell J. Underwood, Hirotoshi Tanimoto, Tim H. Parmley, Koso Ohama, John B. Beard
Publikováno v:
Journal of the Society for Gynecologic Investigation. 7:358-362
Objective:In a continued effort to identify and characterized secreted proteases that are overexpressed in ovarian carcinomas, we discovered the testisin protease as such a candidate. When this dis...
Autor:
Koso Ohama, Hirotoshi Tanimoto, Nobutaka Nagai, K Sakata, Tim H. Parmley, Kazushi Shigemasa, Timothy J. O'Brien
Publikováno v:
Medical Oncology. 17:52-58
Matrix metalloproteases are known to play an important role in tumor invasion by mediating degradation of the extracellular matrix. In this study, we have investigated the immunohistochemical expression of matrix metalloprotease -7 (MMP-7) in 44 muci
Autor:
John Clarke, Timothy J. O'Brien, Kazushi Shigemasa, Tim H. Parmley, Yan Yan, Hirotoshi Tanimoto, J B S Lowell Underwood
Publikováno v:
Cancer. 86:2074-2082
BACKGROUND Proteases play essential roles in the process of tumor invasion and metastasis. The serine protease stratum corneum chymotryptic enzyme (SCCE) has been purified from human stratum corneum and is known to contribute to the cell shedding pro
Autor:
Tim H. Parmley, Kazushi Shigemasa, Timothy J. O'Brien, Koso Ohama, Hirotoshi Tanimoto, Groesbeck P. Parham
Publikováno v:
Journal of the Society for Gynecologic Investigation. 6:102-108
To examine the cyclin D1 mRNA expression level in ovarian tumor samples as compared with normal ovaries and to determine the relationship between cyclin D1 overexpression and p53 mutation status in ovarian tumors.mRNA was isolated and cDNA was prepar
Autor:
Kazushi Shigemasa, Hirotoshi Tanimoto, Groesbeck P. Parham, Tim H. Parmley, Koso Ohama, Timothy J. O'Brien
Publikováno v:
Journal of the Society for Gynecologic Investigation. 6:102-108
Autor:
Kazushi Shigemasa, C. Hu, Timothy J. O'Brien, C. M. West, S. H. Moon, Groesbeck P. Parham, Vicki V. Baker, Sohelia Korourian, Tim H. Parmley
Publikováno v:
International Journal of Gynecological Cancer. 7:296-303
p53 is an important tumor suppressor gene which is activated in response to DNA damage. The induced expression of p53 causes either cell cycle G1 arrest or apoptosis. The recently cloned p21 gene (WAF1/CIP1/SDI1) is known to be directly activated by
Publikováno v:
Tumor Biology. 18:278-289
Evidence is presented suggesting that CA125 is a serine and/or threonine phosphoprotein and that its secretion from the human amnion WISH cell line is closely linked to its phosphorylation. It is also indicated that regulation of CA125 secretion requ
Publikováno v:
American Journal of Obstetrics and Gynecology. 174:174-183
OBJECTIVE: Our purpose was to determine the effect of hyperplasia on cell-to-cell communication in the microvasculature of the human endometrium. STUDY DESIGN: Ten biopsy specimens of simple and complex hyperplasia of the human endometrium were inves