Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Tim H. Heupink"'
Autor:
Anzaan Dippenaar, Nabila Ismail, Tim H. Heupink, Melanie Grobbelaar, Johannes Loubser, Annelies Van Rie, Robin M. Warren
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Implementation of whole genome sequencing (WGS) for patient care is hindered by limited Mycobacterium tuberculosis (Mtb) in clinical specimens and slow Mtb growth. We evaluated droplet multiple displacement amplification (dMDA) for amplifica
Externí odkaz:
https://doaj.org/article/bb85ec90990f42c3bc897a1f886ce1b5
The MAGMA pipeline for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samples
Autor:
Tim H. Heupink, Lennert Verboven, Abhinav Sharma, Vincent Rennie, Miguel de Diego Fuertes, Robin M. Warren, Annelies Van Rie
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/341f31dad2b949e1b88155817cd8879f
Autor:
Annelies Van Rie, Elise De Vos, Emilyn Costa, Lennert Verboven, Felex Ndebele, Tim H. Heupink, Steven Abrams, SMARTT team, Boitumelo Fanampe, Anneke Van der Spoel Van Dyk, Salome Charalambous, Gavin Churchyard, Rob Warren
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Rifampicin-resistant tuberculosis (RR-TB) remains an important global health problem. Ideally, the complete drug-resistance profile guides individualized treatment for all RR-TB patients, but this is only practised in high-income
Externí odkaz:
https://doaj.org/article/f5ceb4d6254c47bb83c29ade3dc9634e
Autor:
Emmanuel Rivière, Lennert Verboven, Anzaan Dippenaar, Sander Goossens, Elise De Vos, Elizabeth Streicher, Bart Cuypers, Kris Laukens, Fathia Ben-Rached, Timothy C. Rodwell, Arnab Pain, Robin M. Warren, Tim H. Heupink, Annelies Van Rie
Publikováno v:
Antimicrobial agents and chemotherapy, vol 66, iss 7
Antimicrobial agents and chemotherapy
Antimicrob Agents Chemother
Antimicrobial agents and chemotherapy
Antimicrob Agents Chemother
Studies have shown that variants in bedaquiline-resistance genes can occur in isolates from bedaquiline-naive patients. We assessed the prevalence of variants in all bedaquiline-candidate-resistance genes in bedaquiline-naive patients, investigated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839c89dd48b4219dd3ab650c725c46b3
https://escholarship.org/uc/item/05v1666v
https://escholarship.org/uc/item/05v1666v
Autor:
Robin M. Warren, Annelies Van Rie, David M. Engelthaler, Megan Folkerts, Tim H. Heupink, Christopher J. Allender, Jason Limberis, John Z. Metcalfe, Michael G. Whitfield
Publikováno v:
Journal of clinical microbiology
Background: Pyrazinamide is an important component of both drug-susceptible and drug-resistant tuberculosis treatment regimens. Although approximately 50% of rifampicin resistant isolates are also resistant to pyrazinamide, pyrazinamide susceptibilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7170ff74c555b01b680ab7c9f27a59e
https://doi.org/10.1128/jcm.01907-21
https://doi.org/10.1128/jcm.01907-21
Autor:
Selien Oostvogels, Serej D. Ley, Tim H. Heupink, Anzaan Dippenaar, Elizabeth M. Streicher, Elise De Vos, Conor J. Meehan, Keertan Dheda, Rob Warren, Annelies Van Rie
Publikováno v:
Microbial Genomics
Extensively drug-resistant tuberculosis (XDR-TB), defined as resistance to at least isoniazid (INH), rifampicin (RIF), a fluoroquinolone (FQ) and a second-line injectable drug (SLID), is difficult to treat and poses a major threat to TB control. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d511e8ff439cc67c0bb5266dc2f964c8
https://repository.uantwerpen.be/docstore/d:irua:12855
https://repository.uantwerpen.be/docstore/d:irua:12855
Publikováno v:
PLoS ONE
Following a huge global effort, the first World Health Organization (WHO)-endorsed catalogue of 17,356 variants in the Mycobacterium tuberculosis complex along with their classification as associated with resistance (interim), not associated with res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c33ffe9b0e1e8388b7a24256787b223
https://repository.uantwerpen.be/docstore/d:irua:16194
https://repository.uantwerpen.be/docstore/d:irua:16194
Autor:
Sander N Goossens, Tim H Heupink, Elise De Vos, Anzaan Dippenaar, Margaretha De Vos, Rob Warren, Annelies Van Rie
Publikováno v:
Briefings in Bioinformatics
Briefings in bioinformatics
Briefings in bioinformatics
The study of genetic minority variants is fundamental to the understanding of complex processes such as evolution, fitness, transmission, virulence, heteroresistance and drug tolerance in Mycobacterium tuberculosis (Mtb). We evaluated the performance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73fd930db3ce9508ce703133f1dd14ac
https://doi.org/10.1093/bib/bbab541
https://doi.org/10.1093/bib/bbab541
Publikováno v:
Microbial Genomics
Improved understanding of the genomic variants that allow Mycobacterium tuberculosis (Mtb) to acquire drug resistance, or tolerance, and increase its virulence are important factors in controlling the current tuberculosis epidemic. Current approaches
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146ca6ffce88b5fe2f48ba2b7482059c
https://doi.org/10.1101/2021.09.16.460612
https://doi.org/10.1101/2021.09.16.460612
Whole-genome sequencing for TB source investigations : principles of ethical precision public health
Autor:
Eric T. Juengst, P-J. Ceyssens, Vanessa Mathys, Fernando González-Candelas, W.A. de Onate, A. Forier, D.G. de Viedma, E. De Vos, Guido Groenen, Iñaki Comas, Conor J. Meehan, Tim H. Heupink, A. Van Rie
Publikováno v:
International journal of tuberculosis and lung disease
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
[Background]: Whole-genome sequencing (WGS) of Mycobacterium tuberculosis allows rapid, accurate inferences about the sources, location and timing of transmission. However, in an era of heightened concern for personal privacy and science distrust, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7aac6976e3a2a28808e2e5b297f7456