Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Tim Guo"'
Autor:
Jeffrey M. Besterman, Amal Wahhab, Alain Ajamian, Martin Allan, Sylvain Lefebvre, Alina Nicolescu, Robert Deziel, Eric Therrien, Jacques Rodrigue, Sukhdev Manku, Jubrail Rahil, Andrea J. Petschner, Zuomei Li, Marielle Fournel, James Wang, Tim Guo, Natalie Nguyen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1866-1870
We have recently reported on a novel class of histone deacetylase (HDAC) inhibitors bearing a sulfamide group as the zinc-binding unit. Herein, we report on the synthesis of sulfamide based inhibitors designed around a lysine scaffold and their struc
Autor:
Pieter Leyssen, Tim Guo, Edith Bellavance, Jeff A. O'Meara, Frédéric H. Vaillancourt, Johan Neyts, Sophie Desmeules, Catherine Spickler, Annick Gauthier, Anne Decor, Marie-Kristine Laberge, Michael Franti, Michel Garneau, Oliver Hucke, Julie Lippens
Publikováno v:
Antimicrobial Agents and Chemotherapy
Human rhinovirus (HRV) is the predominant cause of the common cold, but more importantly, infection may have serious repercussions in asthmatics and chronic obstructive pulmonary disorder (COPD) patients. A cell-based antiviral screen against HRV was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3158aa392429b97e0166f0521fe24291
https://europepmc.org/articles/PMC3697394/
https://europepmc.org/articles/PMC3697394/
Autor:
Léa Constantineau Forget, Cyrille Kuhn, Vida Gorys, Colette Boucher, Chantal Grand-Maître, Sylvain Bordeleau, Michael J. Little, Christian Brochu, Tim Guo, Marc Pesant, Michel Garneau, Megan Bertrand-Laperle, Catherine Spickler, Gulrez Fazal, Pascal Turcotte, Annick Gauthier, Eric Malenfant, Josée Bordeleau, Anne Decor, Jeff A. O'Meara, Ghiro Elise, Oliver Hucke
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(13)
We describe here the design, synthesis and biological evaluation of antiviral compounds acting against human rhinovirus (HRV). A series of aminothiazoles demonstrated pan-activity against the HRV genotypes screened and productive structure-activity r