Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tim Fergestad"'
Autor:
Barry Ganetzky, Gail A. Robertson, Ashleigh E. Schaffer, Harinath Sale, Tim Fergestad, Bret L. Bostwick, Lingling Ho
Publikováno v:
Proceedings of the National Academy of Sciences. 107:5617-5621
To signal properly, excitable cells must establish and maintain the correct balance of various types of ion channels that increase or decrease membrane excitability. The mechanisms by which this balance is regulated remain largely unknown. Here, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ed35c9e724c78c5298da5a2235f7e8
https://doi.org/10.1073/pnas.1001494107
https://doi.org/10.1073/pnas.1001494107
Autor:
Tim Fergestad, Emma Rushton, Jeffrey Rohrbough, Elvin Woodruff, Krishanthan Vigneswaran, Kendal Broadie
Publikováno v:
Genes & Development. 21:2607-2628
Formation and regulation of excitatory glutamatergic synapses is essential for shaping neural circuits throughout development. In a Drosophila genetic screen for synaptogenesis mutants, we identified mind the gap (mtg), which encodes a secreted, extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060cff1462c904d13f468eed05c60283
https://doi.org/10.1101/gad.1574107
https://doi.org/10.1101/gad.1574107
Autor:
Karolyn F. Buttle, Alicia M. Celotto, Wayne A. Van Voorhies, Adam C Frank, Steven W McGrath, Carmen A. Mannella, Michael J. Palladino, Tim Fergestad
Publikováno v:
The Journal of Neuroscience. 26:810-820
Mitochondrial encephalomyopathies are common and devastating multisystem genetic disorders characterized by neuromuscular dysfunction and tissue degeneration. Point mutations in the human mitochondrialATP6gene are known to cause several related mitoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f447cbec061cc8f79ed33392c9862f2
https://doi.org/10.1523/jneurosci.4162-05.2006
https://doi.org/10.1523/jneurosci.4162-05.2006
Autor:
Tim Fergestad, Kendal Broadie
Publikováno v:
The Journal of Neuroscience. 21:1218-1227
TheDrosophiladicistronicstonedlocus encodes two distinctive presynaptic proteins, Stoned A (STNA) and Stoned B (STNB); STNA is a novel protein without homology to known synaptic proteins, and STNB contains a domain with homology to the endocytotic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98670fb3eebecc4c3e25d5ad35e59106
https://doi.org/10.1523/jneurosci.21-04-01218.2001
https://doi.org/10.1523/jneurosci.21-04-01218.2001
Publikováno v:
The Journal of Neuroscience. 19:5847-5860
TheDrosophila stonedlocus was identified 25 years ago on the basis of stress-sensitive behavioral mutants (Grigliatti et al., 1973). The locus is dicistronic and encodes two distinct proteins, stoned A and stoned B, which are expressed specifically i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d3d453fa3e2af5caf6608d0bc20d4c
https://doi.org/10.1523/jneurosci.19-14-05847.1999
https://doi.org/10.1523/jneurosci.19-14-05847.1999
Publikováno v:
Neuron. 23(3):593-605
Biochemical studies suggest that syntaxin 1A participates in multiple protein–protein interactions in the synaptic terminal, but the in vivo significance of these interactions is poorly understood. We used a targeted mutagenesis approach to elimina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657315b0fbefe61508c76b38cca8c469
Autor:
Barry Ganetzky, Rosie Miller, Michael J. Palladino, Khelan P. Patel, Tim Fergestad, Lisa Olson
Publikováno v:
Genetics. 178(2)
Genetic factors are known to contribute to seizure susceptibility, although the long-term effects of these predisposing factors on neuronal viability remain unclear. To examine the consequences of genetic factors conferring increased seizure suscepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572b9a2556a4b0facd7dfd217c577f17
https://pubmed.ncbi.nlm.nih.gov/18245348
https://pubmed.ncbi.nlm.nih.gov/18245348
Autor:
Tim Fergestad, Anand Selvaraj, Walter Schaffner, Oleg Georgiev, Gerd Multhaup, Dieter Egli, Hasmik Yepiskoposyan, Carina Treiber
Publikováno v:
Nucleic Acids Research
All organisms are confronted with external variations in trace element abundance. To elucidate the mechanisms that maintain metal homeostasis and protect against heavy metal stress, we have determined the transcriptome responses in Drosophila to subl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbe6c940e8c8fe76bb68821d13d0609
https://pubmed.ncbi.nlm.nih.gov/16973896
https://pubmed.ncbi.nlm.nih.gov/16973896
We examined a number of Drosophila mutants with increased susceptibility to seizures following mechanical or electrical stimulation to better understand the underlying factors that predispose neurons to aberrant activity. Several mutations in this cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bb1b979530ecdd58de3b34747f8206
https://europepmc.org/articles/PMC1526683/
https://europepmc.org/articles/PMC1526683/
Mutations affecting ion channels and neuronal membrane excitability have been identified in Drosophila as well as in other organisms and characterized for their acute effects on behavior and neuronal function. However, the long-term effect of these p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4efddd3c52c9d9b797975b737a653fc
https://europepmc.org/articles/PMC1456203/
https://europepmc.org/articles/PMC1456203/