Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Tim Fat Tam"'
Publikováno v:
Current Medicinal Chemistry. 13:547-581
A better understanding of the biological roles and the pathological consequences of thiol-dependent enzymes has emerged in recent years, and hence considerable progress has been made in identifying and delineating cysteine proteases that can be consi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ff6686051c99ba92aa5e01a3739e91
https://doi.org/10.2174/092986706776055733
https://doi.org/10.2174/092986706776055733
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 5:367-379
1,2,4-Thiadiazole is a distinctive class of small heterocyclic thiol trapping agents that serve as an interesting pharmacophore in the design of inhibitors targeting the cysteine residues of proteins. X-Ray crystal structures of enzyme-inhibitor comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0752dd5bba75b3c8fcacc04a5ff662b
https://doi.org/10.2174/1389557053544056
https://doi.org/10.2174/1389557053544056
Autor:
Regis Leung-Toung, Michael Spino, Jolanta Maria Wodzinska, Jayme Lowrie, Khashayar Karimian, Craig D. Simpson, Tim Fat Tam, Yanqing Zhao
Publikováno v:
Journal of Medicinal Chemistry. 48:2266-2269
A new class of selective FXIIIa inhibitors with a bicyclic [1,2,4]-thiadiazole pharmacophore is described. At 160 muM, compound 8 caused 50% reduction in fibrin gamma-chain cross-linking and suppressed the polymerization of alpha chains in platelet-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528692eb5cde3ad91d7b2fe2484b4229
https://doi.org/10.1021/jm049221w
https://doi.org/10.1021/jm049221w
Publikováno v:
Current Medicinal Chemistry. 10:983-995
The occurrence of in vivo iron toxicity in the human body can be categorized into iron overload and non-iron overload conditions. Iron overload conditions are common in beta-thalassemia and hereditary hemochromatosis patients, and anthracycline media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac9d448ca707fb71c563ce8036ea6aa
https://doi.org/10.2174/0929867033457593
https://doi.org/10.2174/0929867033457593
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 61:m2601-m2603
In the crystal structure of the title compound, [Fe(C11H13N2O3)3]·1.5C3H7NO·2H2O, the FeIII ion is six-coordinated in a distorted octahedral configuration consisting of six donor O atoms from three bidentate ligands. The Fe complex crystallizes w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42da83c856fd16769b32ffc33139349c
https://doi.org/10.1107/s1600536805036251
https://doi.org/10.1107/s1600536805036251
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 61:m2055-m2057
In the crystal structure of the title compound, Fe(C9H11N2O3)3·2C3H7NO, the FeIII ion is six-coordinate with a distorted octahedral configuration consisting of six donor O atoms from three bidentate ligands. Two of the amide NH groups are involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b550165e8bf55d2fd599c300fc4966de
https://doi.org/10.1107/s1600536805029776
https://doi.org/10.1107/s1600536805029776
Autor:
Desilets Denis, Wanren Li, Khashayar Karimian, Rahul Kukreja, Tim Fat Tam, Regis Leung-Toung, Jolanta Maria Wodzinska, Jayme Lowrie
Publikováno v:
Bioorganicmedicinal chemistry. 11(24)
A novel class of Cathepsin B inhibitors has been developed with a 1,2,4-thiadiazole heterocycle as the thiol trapping pharmacophore. Several compounds with different dipeptide recognition sequence (i.e., P1′ – P2′= Leu-Pro-OH or P2 – P1 =Cbz-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebbe1055995a8422b512ef44bbddb7f
https://pubmed.ncbi.nlm.nih.gov/14642597
https://pubmed.ncbi.nlm.nih.gov/14642597
Publikováno v:
Current medicinal chemistry. 9(9)
Biological thiol-dependent enzymes have recently received extensive attention in the literature because of their involvement in a variety of physiopathological conditions. The active thiol groups of these enzymes are derived from the cysteine residue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd76abee5598c23397e4a6cf4166c00
https://pubmed.ncbi.nlm.nih.gov/11966457
https://pubmed.ncbi.nlm.nih.gov/11966457
Autor:
Everton Thomas, Leslie J. Copp, Allen Krantz, Robin W. Spencer, Tim Fat Tam, Liak Teng J, Steven P. Rafferty
Publikováno v:
Journal of medicinal chemistry. 33(2)
4H-3,1-Benzoxazin-4-ones are alternate substrate inhibitors of the serine proteinase human leukocyte elastase (HL elastase) and form acyl enzyme intermediates during enzyme catalysis. We have synthesized a large variety of benzoxazinones using specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3237a674fc1cb51345cd6e94178c6ad9
https://pubmed.ncbi.nlm.nih.gov/2299617
https://pubmed.ncbi.nlm.nih.gov/2299617
Autor:
Tim Fat Tam, Peter Coles
Publikováno v:
Synthesis. 1988:383-386
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ca6f5c9ae63e4107b018983aa560254
https://doi.org/10.1055/s-1988-27582
https://doi.org/10.1055/s-1988-27582