Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tim Ebert"'
Autor:
Jakob Hartmann, Thomas Bajaj, Joy Otten, Claudia Klengel, Tim Ebert, Anne-Kathrin Gellner, Ellen Junglas, Kathrin Hafner, Elmira A. Anderzhanova, Fiona Tang, Galen Missig, Lindsay Rexrode, Daniel T. Trussell, Katelyn X. Li, Max L. Pöhlmann, Sarah Mackert, Thomas M. Geiger, Daniel E. Heinz, Roy Lardenoije, Nina Dedic, Kenneth M. McCullough, Tomasz Próchnicki, Thomas Rhomberg, Silvia Martinelli, Antony Payton, Andrew C. Robinson, Valentin Stein, Eicke Latz, William A. Carlezon, Felix Hausch, Mathias V. Schmidt, Chris Murgatroyd, Sabina Berretta, Torsten Klengel, Harry Pantazopoulos, Kerry J. Ressler, Nils C. Gassen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. Here we show that secretory autophagy (SA), a non-lytic moda
Externí odkaz:
https://doaj.org/article/83209dbad20940cdab3e3f6f4104353f
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Autor:
Silvia Martinelli, Elmira A. Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E. Heinz, Tim Ebert, Jakob Hartmann, Thomas M. Geiger, Michael Döngi, Kathrin Hafner, Max L. Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V. Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W. Turck, Mathias V. Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C. Gassen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor pro
Externí odkaz:
https://doaj.org/article/4b82f8ddb5c141baac1137b7deee6057
Autor:
Nils C. Gassen, Jan Papies, Thomas Bajaj, Jackson Emanuel, Frederik Dethloff, Robert Lorenz Chua, Jakob Trimpert, Nicolas Heinemann, Christine Niemeyer, Friderike Weege, Katja Hönzke, Tom Aschman, Daniel E. Heinz, Katja Weckmann, Tim Ebert, Andreas Zellner, Martina Lennarz, Emanuel Wyler, Simon Schroeder, Anja Richter, Daniela Niemeyer, Karen Hoffmann, Thomas F. Meyer, Frank L. Heppner, Victor M. Corman, Markus Landthaler, Andreas C. Hocke, Markus Morkel, Nikolaus Osterrieder, Christian Conrad, Roland Eils, Helena Radbruch, Patrick Giavalisco, Christian Drosten, Marcel A. Müller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Viruses manipulate host cell pathways to support infection. Here the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
Externí odkaz:
https://doaj.org/article/a210cbf8766241fd8d824076b3b287b5
Autor:
Daniel E. Heinz, Vivian A. Schöttle, Paulina Nemcova, Florian P. Binder, Tim Ebert, Katharina Domschke, Carsten T. Wotjak
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Anxiety-like behavior of rodents is frequently accompanied by reduced exploration. Here, we identify dissociable components of anxiety, fear, and exploratory drive of sated and foraging mice. With the help of behavioral assays, including the
Externí odkaz:
https://doaj.org/article/871cc969e65448db89a3e617199aa7f6
Autor:
Tim Ebert, Daniel E. Heinz, Suellen Almeida-Corrêa, Renata Cruz, Frederik Dethloff, Tibor Stark, Thomas Bajaj, Oriana M. Maurel, Fabiola M. Ribeiro, Silvio Calcagnini, Kathrin Hafner, Nils C. Gassen, Christoph W. Turck, Benoit Boulat, Michael Czisch, Carsten T. Wotjak
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Dementia is a devastating age-related disorder. Its therapy would largely benefit from the identification of susceptible subjects at early, prodromal stages of the disease. To search for such prognostic markers of cognitive impairment, we studied spa
Externí odkaz:
https://doaj.org/article/1c3f47f1e2ad4e5ab5d21e8c3ed79cbb
Autor:
Leonie Herrmann, Tim Ebert, Helena Rosen, Bozidar Novak, Alexandra Philipsen, Chadi Touma, Monika Schreckenbach, Nils C. Gassen, Theo Rein, Ulrike Schmidt
Publikováno v:
Neurobiology of Stress, Vol 15, Iss , Pp 100401- (2021)
As the cerebellar molecular stress response is understudied, we assessed protein expression levels of hypothalamic-pituitary-adrenal (HPA) axis regulators and neurostructural markers in the cerebellum of a male PTSD mouse model and of unstressed vs.
Externí odkaz:
https://doaj.org/article/17791f55f2c54368988cadadeaf707b2
Publikováno v:
EDIS, Vol 2021, Iss 1 (2021)
Canopy management is a useful tool to induce precocity and maintain high production of optimum-sized, high-quality fruit. The aim of this new 8-page publication of the UF/IFAS Department of Soil and Water Sciences is to provide growers with practical
Externí odkaz:
https://doaj.org/article/796400b8aeac48579cc6613a6bf460b0
Autor:
Henrik Rohner, Nikolas Gaspar, Helena Rosen, Tim Ebert, Laura Luisa Kilarski, Felix Schrader, Moaz Al Istwani, Anna Julia Lenz, Christoph Dilg, Andrea Welskop, Tatjana Goldmann, Ulrike Schmidt, Alexandra Philipsen
Publikováno v:
International Journal of Environmental Research and Public Health
Volume 20
Issue 3
Pages: 2534
Volume 20
Issue 3
Pages: 2534
(1) Background: Attention deficit hyperactivity disorder (ADHD) is a common comorbid condition in opioid use disorder (OUD) and is associated with a more severe course of substance use. Patients with severe OUD who have not responded to oral opioid m
Autor:
Florian P. Binder, Vivian A. Schöttle, Carsten T. Wotjak, Tim Ebert, Daniel E. Heinz, Katharina Domschke, Paulina Nemcova
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Anxiety-like behavior of rodents is frequently accompanied by reduced exploration. Here, we identify dissociable components of anxiety, fear, and exploratory drive of sated and foraging mice. With the help of behavioral assays, including the open fie
Autor:
Jens, Stepan, Daniel E, Heinz, Frederik, Dethloff, Thomas, Bajaj, Andreas, Zellner, Kathrin, Hafner, Svenja, Wiechmann, Sarah, Mackert, Yara, Mecdad, Michael, Rabenstein, Tim, Ebert, Silvia, Martinelli, Alexander S, Häusl, Maximilian L, Pöhlmann, Anke, Hermann, Xiao, Ma, Hermann, Pavenstädt, Mathias V, Schmidt, Alexandra, Philipsen, Chris W, Turck, Jan M, Deussing, Bernhard, Kuster, Michael C, Wehr, Valentin, Stein, Joachim, Kremerskothen, Carsten T, Wotjak, Nils C, Gassen
Publikováno v:
Cell reports. 41(10)
Learning and memory rely on changes in postsynaptic glutamergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type receptor (AMPAR) number, spatial organization, and function. The Hippo pathway component WW and C2 domain-containing pro