Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Tim E. Sparer"'
Autor:
J. Jason Collier, Heidi M. Batdorf, Thomas M. Martin, Kristen E. Rohli, David H. Burk, Danhong Lu, Chris R. Cooley, Michael D. Karlstad, Joseph W. Jackson, Tim E. Sparer, Jingying Zhang, Randall L. Mynatt, Susan J. Burke
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101140- (2021)
Objective: The expression of the interleukin-1 receptor type I (IL-1R) is enriched in pancreatic islet β-cells, signifying that ligands activating this pathway are important for the health and function of the insulin-secreting cell. Using isolated m
Externí odkaz:
https://doaj.org/article/1a3edd9950484f2c84401d8bd197de64
Publikováno v:
Pathogens, Vol 10, Iss 12, p 1577 (2021)
Human cytomegalovirus (HCMV) is a ubiquitous pathogen infecting a majority of people worldwide, with diseases ranging from mild to life-threatening. Its clinical relevance in immunocompromised people and congenital infections have made treatment and
Externí odkaz:
https://doaj.org/article/56c0e14f095c49f7adfe9ff66fdf1e3d
Autor:
Joseph W. Jackson, Trevor J. Hancock, Ellen LaPrade, Pranay Dogra, Eric R. Gann, Thomas J. Masi, Ravichandran Panchanathan, William E. Miller, Steven W. Wilhelm, Tim E. Sparer
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Human cytomegalovirus (HCMV) is a betaherpesvirus that is a significant pathogen within newborn and immunocompromised populations. Morbidity associated with HCMV infection is the consequence of viral dissemination. HCMV has evolved to manipu
Externí odkaz:
https://doaj.org/article/e4048cfb69db4c07933ccf541f647b2c
Autor:
Joseph W. Jackson, Trevor J. Hancock, Pranay Dogra, Ravi Patel, Ravit Arav-Boger, Angela D. Williams, Stephen J. Kennel, Jonathan S. Wall, Tim E. Sparer
Publikováno v:
mSphere, Vol 4, Iss 1 (2019)
ABSTRACT Human cytomegalovirus (HCMV) is a ubiquitous betaherpesvirus that can cause severe disease following in utero exposure, during primary infection, or latent virus reactivation in immunocompromised populations. These complications lead to a 1-
Externí odkaz:
https://doaj.org/article/bfe1c8b9badd479a977a7cc7b9f954e9
Autor:
Trevor J. Hancock, Peyton Hickman, Niloo Kazerooni, Melissa Kennedy, Stephen A. Kania, Michelle Dennis, Nicole Szafranski, Richard Gerhold, Chunlei Su, Tom Masi, Stephen Smith, Tim E. Sparer
Publikováno v:
Journal of Virology. 96
In late 2019, a novel coronavirus began circulating within humans in central China. It was designated SARS-CoV-2 because of its genetic similarities to the 2003 SARS coronavirus (SARS-CoV). Now that SARS-CoV-2 has spread worldwide, there is a risk of
Autor:
Trevor J. Hancock, Peyton Hickman, Niloo Kazerooni, Melissa Kennedy, Stephen A. Kania, Michelle Dennis, Nicole Szafranski, Richard Gerhold, Chunlei Su, Tom Masi, Stephen Smith, Tim E. Sparer
In late 2019, a novel coronavirus began circulating within humans in central China. It was designated SARS-CoV-2 because of its genetic similarities to the 2003 SARS coronavirus (SARS-CoV). Now that SARS-CoV-2 has spread worldwide, there is a risk of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43416a6b0a66073d70cd76d575d774fb
https://doi.org/10.1101/2021.12.17.473265
https://doi.org/10.1101/2021.12.17.473265
Autor:
Mikayla M. Mangrum, Trevor J. Hancock, Elise K. Phillips, Tim E. Sparer, Todd B. Reynolds, Stephen W. Lumsdaine, Sarah Kauffman, Andrew S. Wagner
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 8, p e1009839 (2021)
PLoS Pathogens, Vol 17, Iss 8, p e1009839 (2021)
Masking the immunogenic cell wall epitope ß(1,3)-glucan under an outer layer of mannosylated glycoproteins is an important virulence factor deployed by Candida albicans during infection. Consequently, increased ß(1,3)-glucan exposure (unmasking) re
Autor:
Tim E. Sparer, David H. Burk, Danhong Lu, Jingying Zhang, Joseph W. Jackson, J. Jason Collier, Michael D. Karlstad, Chris R. Cooley, Randall L. Mynatt, Kristen E. Rohli, Susan J. Burke, Thomas M. Martin, Heidi M. Batdorf
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 44, Iss, Pp 101140-(2021)
Molecular Metabolism, Vol 44, Iss, Pp 101140-(2021)
Objective The expression of the interleukin-1 receptor type I (IL-1R) is enriched in pancreatic islet β-cells, signifying that ligands activating this pathway are important for the health and function of the insulin-secreting cell. Using isolated mo
Autor:
Andrew S. Wagner, Robert N. Tams, Tim E. Sparer, Todd B. Reynolds, Joseph W. Jackson, Eric R. Gann
Publikováno v:
Infect Immun
Candida albicans is a leading cause of systemic bloodstream infections, and synthesis of the phospholipid phosphatidylethanolamine (PE) is required for virulence. The psd1Δ/Δ psd2Δ/Δ mutant, which cannot synthesize PE by the cytidine diphosphate
Publikováno v:
Journal of Molecular Endocrinology. 59:R33-R46
Both type 1 and type 2 diabetes exhibit features of inflammation associated with alterations in pancreatic islet function and mass. These immunological disruptions, if unresolved, contribute to the overall pathogenesis of disease onset. This review p