Zobrazeno 1 - 10
of 320
pro vyhledávání: '"Tim E A Peto"'
Autor:
Nicholas D Sanderson, Teresa L Street, Dona Foster, Jeremy Swann, Bridget L Atkins, Andrew J Brent, Martin A McNally, Sarah Oakley, Adrian Taylor, Tim E A Peto, Derrick W Crook, David W Eyre
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Prosthetic joint infections are clinically difficult to diagnose and treat. Previously, we demonstrated metagenomic sequencing on an Illumina MiSeq replicates the findings of current gold standard microbiological diagnostic techni
Externí odkaz:
https://doaj.org/article/c5f452b9fa8e41939226193e8d81a365
Autor:
Tjibbe Donker, Timo Smieszek, Katherine L Henderson, Timothy M Walker, Russell Hope, Alan P Johnson, Neil Woodford, Derrick W Crook, Tim E A Peto, A Sarah Walker, Julie V Robotham
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219994 (2019)
Hospital performance is often measured using self-reported statistics, such as the incidence of hospital-transmitted micro-organisms or those exhibiting antimicrobial resistance (AMR), encouraging hospitals with high levels to improve their performan
Externí odkaz:
https://doaj.org/article/48622265c61b4ae19f2a7cbc6e693421
Autor:
Leon Peto, Nicola J Fawcett, Derrick W Crook, Tim E A Peto, Martin J Llewelyn, A Sarah Walker
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0222831 (2019)
Metagenomic sequencing of fecal DNA can usefully characterise an individual's intestinal resistome but is limited by its inability to detect important pathogens that may be present at low abundance, such as carbapenemase or extended-spectrum beta-lac
Externí odkaz:
https://doaj.org/article/02ce79ac9e4343bd99abdac464ff174b
Autor:
Nicole Stoesser, David W Eyre, T Phuong Quan, Heather Godwin, Gemma Pill, Emily Mbuvi, Alison Vaughan, David Griffiths, Jessica Martin, Warren Fawley, Kate E Dingle, Sarah Oakley, Kazimierz Wanelik, John M Finney, Melina Kachrimanidou, Catrin E Moore, Sherwood Gorbach, Thomas V Riley, Derrick W Crook, Tim E A Peto, Mark H Wilcox, A Sarah Walker, Modernising Medical Microbiology Informatics Group (MMMIG)
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182307 (2017)
BackgroundApproximately 30-40% of children MethodsPredominantly healthy infants (≤2 years) were recruited in Oxfordshire, UK, and provided ≥1 fecal samples. Independent risk factors for toxigenic/non-toxigenic C. difficile colonization and acquis
Externí odkaz:
https://doaj.org/article/c63857e3d72c498b9013180f0a53579a
Autor:
Elizabeth M Batty, T H Nicholas Wong, Amy Trebes, Karène Argoud, Moustafa Attar, David Buck, Camilla L C Ip, Tanya Golubchik, Madeleine Cule, Rory Bowden, Charis Manganis, Paul Klenerman, Eleanor Barnes, A Sarah Walker, David H Wyllie, Daniel J Wilson, Kate E Dingle, Tim E A Peto, Derrick W Crook, Paolo Piazza
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66129 (2013)
To date, very large scale sequencing of many clinically important RNA viruses has been complicated by their high population molecular variation, which creates challenges for polymerase chain reaction and sequencing primer design. Many RNA viruses are
Externí odkaz:
https://doaj.org/article/a2407922c58b47e5ad9a468cfd3fdb1b
Autor:
David W Eyre, A Sarah Walker, Jane Freeman, Simon D Baines, Warren N Fawley, Caroline H Chilton, David Griffiths, Alison Vaughan, Derrick W Crook, Tim E A Peto, Mark H Wilcox
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63540 (2013)
BACKGROUND:Clostridium difficile whole genome sequencing has the potential to identify related isolates, even among otherwise indistinguishable strains, but interpretation depends on understanding genomic variation within isolates and individuals. ME
Externí odkaz:
https://doaj.org/article/6e912cdeea5b44d48186134b1e985a14
Autor:
David W Eyre, Madeleine L Cule, David Griffiths, Derrick W Crook, Tim E A Peto, A Sarah Walker, Daniel J Wilson
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 5, p e1003059 (2013)
Bacterial whole genome sequencing offers the prospect of rapid and high precision investigation of infectious disease outbreaks. Close genetic relationships between microorganisms isolated from different infected cases suggest transmission is a stron
Externí odkaz:
https://doaj.org/article/dc295706127a41d3829a0ed75aca69a8
Autor:
David W Eyre, David Griffiths, Alison Vaughan, Tanya Golubchik, Milind Acharya, Lily O'Connor, Derrick W Crook, A Sarah Walker, Tim E A Peto
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78445 (2013)
INTRODUCTION:Combined genotyping/whole genome sequencing and epidemiological data suggest that in endemic settings only a minority of Clostridium difficile infection, CDI, is acquired from other cases. Asymptomatic patients are a potential source for
Externí odkaz:
https://doaj.org/article/a7feb8efcc4d4f16b41d857ac4d6b4e9
Autor:
A Sarah Walker, David W Eyre, David H Wyllie, Kate E Dingle, Rosalind M Harding, Lily O'Connor, David Griffiths, Ali Vaughan, John Finney, Mark H Wilcox, Derrick W Crook, Tim E A Peto
Publikováno v:
PLoS Medicine, Vol 9, Iss 2, p e1001172 (2012)
BACKGROUND:Clostridium difficile infection (CDI) is a leading cause of antibiotic-associated diarrhoea and is endemic in hospitals, hindering the identification of sources and routes of transmission based on shared time and space alone. This may comp
Externí odkaz:
https://doaj.org/article/e192a1bc565b42c2914e84acee1244c1
Autor:
Iryna Schlackow, A Sarah Walker, Kate Dingle, David Griffiths, Sarah Oakley, John Finney, Ali Vaughan, Martin J Gill, Derrick W Crook, Tim E A Peto, David H Wyllie
Publikováno v:
PLoS Medicine, Vol 9, Iss 7, p e1001279 (2012)
BackgroundChanging clinical impact, as virulent clones replace less virulent ones, is a feature of many pathogenic bacterial species and can be difficult to detect. Consequently, innovative techniques monitoring infection severity are of potential cl
Externí odkaz:
https://doaj.org/article/648154b7be5c44d785f523d8b541776a