Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Tim E, Cawston"'
Publikováno v:
Arthritis & Rheumatology. 66:979-989
Objective To use a novel computational approach to examine the molecular pathways involved in cartilage breakdown and to use computer simulation to test possible interventions for reducing collagen release. Methods We constructed a computational mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80e20d9999e0e4593009403127d7b7ac
https://doi.org/10.1002/art.38297
https://doi.org/10.1002/art.38297
Autor:
David Young, Andrew D. Rowan, M Elias, Gareth I Kitson, Gary J. Litherland, Tim E. Cawston, Wang Hui
Publikováno v:
Annals of the Rheumatic Diseases. 71:455-462
ObjectivesTo investigate the effect of leptin on cartilage destruction.MethodsCollagen release was assessed in bovine cartilage explant cultures, while collagenolytic and gelatinolytic activities in culture supernatants were determined by bioassay an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d173e6f6a30424deaaa1071ae05a01
https://doi.org/10.1136/annrheumdis-2011-200372
https://doi.org/10.1136/annrheumdis-2011-200372
Autor:
Matthew Jefferson, Tim E. Cawston, M Elias, Gary J. Litherland, Wang Hui, Matt J. Barter, David Young, Andrew D. Rowan
Publikováno v:
Rheumatology. 49:2043-2053
Objectives To determine the effects and mechanism of action of lithium chloride (LiCl) on cartilage destruction induced by the pro-inflammatory cytokines IL-1, IL-1 + oncostatin M and TNF-α. Methods The release of collagen was assessed in bovine car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3309bef76e5851e602f2df2ac5202512
https://doi.org/10.1093/rheumatology/keq217
https://doi.org/10.1093/rheumatology/keq217
Autor:
Tim E. Cawston, Rachel L. Lakey
Publikováno v:
Rheumatology. 48:1208-1212
Objective To investigate the effect of SSZ on the release of GAG and collagen fragments from bovine nasal cartilage and MMP and ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) proteinases from human articular chondrocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d206bfceadeee16edfdd639e1c214f8d
https://doi.org/10.1093/rheumatology/kep236
https://doi.org/10.1093/rheumatology/kep236
Autor:
Tim E. Cawston
Publikováno v:
Nature Protocols. 4:286-290
This protocol describes how to purify and radiolabel collagen for use as a substrate to assay collagenolytic members of the matrix metalloproteinases (MMPs). This assay measures enzymes that specifically cleave native triple helical collagen. After i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3b769be172cd38fcc55c7dfe28e136
https://doi.org/10.1038/nprot.2008.244
https://doi.org/10.1038/nprot.2008.244
Autor:
Rachel L. Lakey, Andrew D. Rowan, John D. Isaacs, Catharien M. U. Hilkens, Tanya G. Morgan, Tim E. Cawston
Publikováno v:
Rheumatology. 48:502-507
Objective. Dendritic cells (DCs) are enriched in RA synovium and have been implicated in the pathogenesis of RA primarily through their ability to present autoantigen and activate T cells. However, whether DCs play an effector role in cartilage destr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2319591c214cd768ed3732e4a2fedb5
https://doi.org/10.1093/rheumatology/kep040
https://doi.org/10.1093/rheumatology/kep040
Autor:
GE Johnson, Ian Forrest, James Lordan, T Small, Desmond M. Murphy, Chris Ward, Andrew J. Fisher, Debbie Jones, Tim E. Cawston, James J. Egan, Paul A. Corris
Publikováno v:
The Journal of Heart and Lung Transplantation. 27:1210-1216
Background The bronchial epithelium is a source of mediators that may play a role in the airway inflammation and remodeling of post-transplant obliterative bronchiolitis (OB). Traditional strategies have failed to have an impact on OB. Recent studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1a3853a287c3dd5d79c9520b209a70
https://doi.org/10.1016/j.healun.2008.07.026
https://doi.org/10.1016/j.healun.2008.07.026
Autor:
Timothy Robson, Tim E. Cawston, Rachel L. Lakey, D Jones, Gary J. Litherland, Craig Dixon, Andrew D. Rowan, David Young
Publikováno v:
Journal of Biological Chemistry. 283:14221-14229
The phosphatidylinositol 3-kinase (PI3K) signaling pathway has emerged as a major regulator of cellular functions and has been implicated in several pathologies involving remodeling of extracellular matrix (ECM). The end stage of inflammatory joint d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9525dcf913bbefbfb93b28dcb6e9f0
https://doi.org/10.1074/jbc.m710136200
https://doi.org/10.1074/jbc.m710136200
Autor:
Jim J. Egan, James Lordan, GE Johnson, Andrew J. Fisher, Debbie Jones, Tim E. Cawston, Paul A. Corris, T Small, Ian Forrest, Desmond M. Murphy, Chris Ward
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 294:L592-L599
Obliterative bronchiolitis (OB), the major cause of chronic lung allograft dysfunction, is characterized by airway neutrophilia, inflammation, and remodeling, with progressive fibroproliferation and obliteration of small airways that ultimately leads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1adb8d0bd6ba1e6e0c8bd8db2d1926f
https://doi.org/10.1152/ajplung.00386.2007
https://doi.org/10.1152/ajplung.00386.2007
Autor:
Matt J. Barter, Andrew D. Rowan, John H. Robinson, David Young, Ian M. Clark, Simon T. Donell, Wang Hui, C. Darrah, Qian Zhang, Gary J. Litherland, Tim E. Cawston, Rose K Davidson
Publikováno v:
Annals of the Rheumatic Diseases. 67:1633-1641
Objectives: To characterise the catabolic response of osteoarthritic chondrocytes to Toll-like receptor (TLR) ligands. Methods: Induction of the collagenases, matrix metalloproteinase (MMP)1 and MMP13, by TLR ligands was assessed in chondrocytes by r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb27109dd4170f6efe0578785f821b0
https://doi.org/10.1136/ard.2007.079574
https://doi.org/10.1136/ard.2007.079574