Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Tim D Oury"'
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118979 (2015)
Several recent clinical studies have implied a role for the receptor for advanced glycation end products (RAGE) and its variants in chronic obstructive pulmonary disease (COPD). In this study we have defined a role for RAGE in the pathogenesis of emp
Externí odkaz:
https://doaj.org/article/4f917b7e83ce4049bad5695c71e3933c
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 4, p e2790 (2014)
BACKGROUND: Development of antiviral drugs that have broad-spectrum activity against a number of viral infections would be of significant benefit. Due to the evolution of resistance to currently licensed antiviral drugs, development of novel anti-inf
Externí odkaz:
https://doaj.org/article/4a9264d3b1264455bb7720e572270893
Autor:
Pavle S Milutinovic, Judson M Englert, Lauren T Crum, Neale S Mason, Lasse Ramsgaard, Jan J Enghild, Louis J Sparvero, Michael T Lotze, Tim D Oury
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e88259 (2014)
Elucidating the sites and mechanisms of sRAGE action in the healthy state is vital to better understand the biological importance of the receptor for advanced glycation end products (RAGE). Previous studies in animal models of disease have demonstrat
Externí odkaz:
https://doaj.org/article/5460daf9654446c8a73aeb84d6de073e
Autor:
Jorna Sojati, Olivia B. Parks, Yu Zhang, Sara Walters, Jie Lan, Taylor Eddens, Dequan Lou, Li Fan, Kong Chen, Tim D. Oury, John V. Williams
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTHuman metapneumovirus (HMPV) is a primary cause of acute respiratory infection, yet there are no approved vaccines or antiviral therapies for HMPV. Early host responses to HMPV are poorly characterized, and further understanding could identif
Externí odkaz:
https://doaj.org/article/556efb1ea68b42d78165f53287a83097
Autor:
Kerry M Empey, Jacob G Orend, R Stokes Peebles, Loreto Egaña, Karen A Norris, Tim D Oury, Jay K Kolls
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40499 (2012)
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral death in infants. Reduced CD8 T-cells and negligible interferon gamma (IFNγ) in the airway are associated with severe infant RSV disease, yet there is an abundance of
Externí odkaz:
https://doaj.org/article/b11946405d9048e8b9eebcb216224227
Autor:
Lasse Ramsgaard, Judson M Englert, Michelle L Manni, Pavle S Milutinovic, Julia Gefter, Jacob Tobolewski, Lauren Crum, Gina M Coudriet, Jon Piganelli, Ruben Zamora, Yoram Vodovotz, Jan J Enghild, Tim D Oury
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20132 (2011)
The receptor for advanced glycation end-products (RAGE) has been suggested to modulate lung injury in models of acute pulmonary inflammation. To study this further, model systems utilizing wild type and RAGE knockout (KO) mice were used to determine
Externí odkaz:
https://doaj.org/article/8a1e9715cde34dad8fe7e205664e7ee7
Autor:
Lasse Ramsgaard, Judson M Englert, Jacob Tobolewski, Lauren Tomai, Cheryl L Fattman, Adriana S Leme, A Murat Kaynar, Steven D Shapiro, Jan J Enghild, Tim D Oury
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9604 (2010)
The role of the receptor for advanced glycation end-products (RAGE) has been shown to differ in two different mouse models of asbestos and bleomycin induced pulmonary fibrosis. RAGE knockout (KO) mice get worse fibrosis when challenged with asbestos,
Externí odkaz:
https://doaj.org/article/f9ea7150ecf74b3b8bdd7545c3dcea4a
Autor:
Olivia B. Parks, Taylor Eddens, Jorna Sojati, Jie Lan, Yu Zhang, Tim D. Oury, Manda Ramsey, John J. Erickson, Craig A. Byersdorfer, John V. Williams
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract Background Lower respiratory infections are a leading cause of severe morbidity and mortality among older adults. Despite ubiquitous exposure to common respiratory pathogens throughout life and near universal seropositivity, antibodies fail
Externí odkaz:
https://doaj.org/article/a81277b15295469988f48d8691c5247f
Autor:
Katherine N. Killian, Jessica L. Kosanovich, Madeline A. Lipp, Kerry M. Empey, Tim D. Oury, Timothy N. Perkins
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundAsthma is a major public healthcare burden, affecting over 300 million people worldwide. While there has been great progress in the treatment of asthma, subsets of patients who present with airway neutrophilia, often have more severe diseas
Externí odkaz:
https://doaj.org/article/44db0d58f3b0474b9f0a2f542afd9426
Autor:
Katherine M. Eichinger, Jessica L. Kosanovich, Timothy N. Perkins, Tim D. Oury, Nikolai Petrovsky, Christopher P. Marshall, Mark A. Yondola, Kerry M. Empey
Publikováno v:
Frontiers in immunology. 13
Respiratory syncytial virus (RSV) remains the most common cause of lower respiratory tract infections in children worldwide. Development of a vaccine has been hindered due the risk of enhanced respiratory disease (ERD) following natural RSV exposure