Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tim Düking"'
Autor:
Egle Kvedaraite, Magda Lourda, Natalia Mouratidou, Tim Düking, Avinash Padhi, Kirsten Moll, Paulo Czarnewski, Indranil Sinha, Ioanna Xagoraris, Efthymia Kokkinou, Anastasios Damdimopoulos, Whitney Weigel, Olga Hartwig, Telma E. Santos, Tea Soini, Aline Van Acker, Nelly Rahkonen, Malin Flodström Tullberg, Emma Ringqvist, Marcus Buggert, Carl Jorns, Ulrik Lindforss, Caroline Nordenvall, Christopher T. Stamper, David Unnersjö-Jess, Mira Akber, Ruta Nadisauskaite, Jessica Jansson, Niels Vandamme, Chiara Sorini, Marijke Elise Grundeken, Helena Rolandsdotter, George Rassidakis, Eduardo J. Villablanca, Maja Ideström, Stefan Eulitz, Henrik Arnell, Jenny Mjösberg, Jan-Inge Henter, Mattias Svensson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Stromal cells support epithelial cell and immune cell homeostasis and play an important role in inflammatory bowel disease (IBD) pathogenesis. Here, we quantify the stromal response to inflammation in pediatric IBD and reveal subset-specific
Externí odkaz:
https://doaj.org/article/4dc18c7a87ab47da922abb5a03ceaf68
Autor:
Stefan A. Berghoff, Tim Düking, Lena Spieth, Jan Winchenbach, Sina K. Stumpf, Nina Gerndt, Kathrin Kusch, Torben Ruhwedel, Wiebke Möbius, Gesine Saher
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-13 (2017)
Abstract In neuroinflammatory disorders such as multiple sclerosis, the physiological function of the blood-brain barrier (BBB) is perturbed, particularly in demyelinating lesions and supposedly secondary to acute demyelinating pathology. Using the t
Externí odkaz:
https://doaj.org/article/d7f11a965962441290665d029f07d603
Autor:
Jan Winchenbach, Tim Düking, Stefan A. Berghoff, Sina K. Stumpf, Swen Hülsmann, Klaus-Armin Nave, Gesine Saher
Publikováno v:
F1000Research, Vol 5 (2016)
Background: Studying astrocytes in higher brain functions has been hampered by the lack of genetic tools for the efficient expression of inducible Cre recombinase throughout the CNS, including the neocortex. Methods: Therefore, we generated BAC trans
Externí odkaz:
https://doaj.org/article/53c8f73488c14ec299224e06b6b62fe4
Autor:
Tim Düking, Lena Spieth, Stefan A. Berghoff, Lars Piepkorn, Annika M. Schmidke, Miso Mitkovski, Nirmal Kannaiyan, Leon Hosang, Patricia Scholz, Ali H. Shaib, Lennart V. Schneider, Dörte Hesse, Torben Ruhwedel, Ting Sun, Lisa Linhoff, Andrea Trevisiol, Susanne Köhler, Adrian Marti Pastor, Thomas Misgeld, Michael Sereda, Imam Hassouna, Moritz J. Rossner, Francesca Odoardi, Till Ischebeck, Livia de Hoz, Johannes Hirrlinger, Olaf Jahn, Gesine Saher
Publikováno v:
Science Advances
Science advances 8(37), eabo7639 (2022). doi:10.1126/sciadv.abo7639
Science advances 8(37), eabo7639 (2022). doi:10.1126/sciadv.abo7639
To maintain homeostasis, the body, including the brain, reprograms its metabolism in response to altered nutrition or disease. However, the consequences of these challenges for the energy metabolism of the different brain cell types remain unknown. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429b042988b73b13bc8c23baed1b8d83
https://hdl.handle.net/21.11116/0000-000B-3BC4-621.11116/0000-000B-3BC6-4
https://hdl.handle.net/21.11116/0000-000B-3BC4-621.11116/0000-000B-3BC6-4
Autor:
Katharina Kronenberg, Thomas Michaelis, Jeong-Seop Rhee, Katrin I. Willig, Lena Spieth, Torben Ruhwedel, Sina K. Stumpf, Takashi Watanabe, Sabine Hofer, Niels Kruse, Tim Düking, Christine Stadelmann, Gesine Saher, Jan Winchenbach, Stefan A. Berghoff, Susana Minguet, Wiebke Möbius, Christian von der Brelie, Ali H Shaib, Nina Gerndt, Peter Michels, Jens Frahm, Petra Hülper, Uwe Karst
Publikováno v:
Neuro-oncology Advances
Neuro-Oncology Advances
Neuro-Oncology Advances
Background Pharmaceutical intervention in the CNS is hampered by the shielding function of the blood–brain barrier (BBB). To induce clinical anesthesia, general anesthetics such as isoflurane readily penetrate the BBB. Here, we investigated whether
Autor:
Lena Spieth, Roman Sankowski, David Ewers, Martin Meschkat, Stefan A. Berghoff, Mikael Simons, Jan Winchenbach, Ting Sun, Julia M. Edgar, Gesine Saher, Torben Ruhwedel, Ludovico Cantuti-Castelvetri, Christine Stadelmann-Nessler, Franziska van der Meer, Francesca Odoardi, Wiebke Möbius, Tim Düking, Klaus-Armin Nave, Michael W. Sereda, Patricia Scholz, Constanze Depp, Lennart Schlaphoff, Marco Prinz, Jonathan Neuber, Andrew Octavian Sasmita, Inge Huitinga, Till Ischebeck, Leon Hosang
Publikováno v:
Nature Neuroscience, 24, 47-60. Nature Publishing Group
Nature neuroscience.
Nature neuroscience 24(1), 47-60 (2021). doi:10.1038/s41593-020-00757-6
Nature neuroscience
Nature neuroscience.
Nature neuroscience 24(1), 47-60 (2021). doi:10.1038/s41593-020-00757-6
Nature neuroscience
The repair of inflamed, demyelinated lesions as in multiple sclerosis (MS) necessitates the clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a pro-inflammatory to an anti-inflammatory lesion environment. Subseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3611e48234b6ab2743ff34a0d63b70e8
https://pure.knaw.nl/portal/en/publications/99839925-2317-482f-84d3-35ccaca51264
https://pure.knaw.nl/portal/en/publications/99839925-2317-482f-84d3-35ccaca51264
Autor:
Wiebke Möbius, Nina Gerndt, Sina K. Stumpf, Torben Ruhwedel, Lena Spieth, Kathrin Kusch, Stefan A. Berghoff, Tim Düking, Jan Winchenbach, Gesine Saher
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-13 (2017)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
In neuroinflammatory disorders such as multiple sclerosis, the physiological function of the blood-brain barrier (BBB) is perturbed, particularly in demyelinating lesions and supposedly secondary to acute demyelinating pathology. Using the toxic non-
Autor:
Lennart Schlaphoff, Gesine Saher, Annette Bley, Lennart V. Schneider, Jutta Gärtner, Heiko Röhse, Kathrin Kusch, Dinah Burfeind, Andrea Trevisiol, Stefan A. Berghoff, Klaus-Armin Nave, Lena Spieth, Steffi Dreha-Kulaczewski, Wiebke Möbius, Tim Düking, Sina K. Stumpf, Philipp Guder, Miso Mitkovski, Jonas Denecke, Torben Ruhwedel
Publikováno v:
Acta Neuropathologica
Pelizaeus–Merzbacher disease (PMD) is an untreatable and fatal leukodystrophy. In a model of PMD with perturbed blood–brain barrier integrity, cholesterol supplementation promotes myelin membrane growth. Here, we show that in contrast to the mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0b895fadae2c1b5ef171128693ebaf
https://hdl.handle.net/21.11116/0000-000D-2F0B-421.11116/0000-0003-54FF-021.11116/0000-0003-5501-C
https://hdl.handle.net/21.11116/0000-000D-2F0B-421.11116/0000-0003-54FF-021.11116/0000-0003-5501-C
Autor:
Lennart Schlaphoff, Jutta Gärtner, Sina K. Stumpf, Lena Spieth, Klaus-Armin Nave, Gesine Saher, Kathrin Kusch, Torben Ruhwedel, Lennart V. Schneider, Heiko Röhse, Jonas Denecke, Stefan A. Berghoff, Wiebke Möbius, Miso Mitkovski, Dinah Burfeind, Steffi Dreha-Kulaczewski, Philipp Guder, Andrea Trevisiol, Tim Düking, Annette Bley
Publikováno v:
Acta Neuropathologica. 138:673-674
peerReviewed
Autor:
Graham R. Campbell, Francisca Diaz, Susann Boretius, Magdalena Götz, Klaus-Armin Nave, Don J. Mahad, Carlos T. Moraes, Tim Düking, Lotti Marianna Supplie, Bernd Hamprecht
Publikováno v:
Supplie, L M, Düking, T, Campbell, G, Diaz, F, Moraes, C T, Götz, M, Hamprecht, B, Boretius, S, Mahad, D & Nave, K-A 2017, ' Respiration-deficient astrocytes survive as glycolytic cells in vivo ', Journal of Neuroscience . https://doi.org/10.1523/JNEUROSCI.0756-16.2017
The Journal of Neuroscience
J. Neurosci. 37, 4231-4242 (2017)
The Journal of Neuroscience
J. Neurosci. 37, 4231-4242 (2017)
Neurons and glial cells exchange energy-rich metabolites and it has been suggested, originally based onin vitrodata, that astrocytes provide lactate to glutamatergic synapses (“lactate shuttle”). Here, we have studied astrocytes that lack mitocho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc635b1b968604d711dff40601d8c4b
https://www.pure.ed.ac.uk/ws/files/36572739/4231.full_1.pdf
https://www.pure.ed.ac.uk/ws/files/36572739/4231.full_1.pdf