Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Tim Czopka"'
Autor:
Tim Czopka
Publikováno v:
PLoS Biology, Vol 22, Iss 7, p e3002691 (2024)
The diversity of oligodendrocyte precursor cells (OPCs) is not well understood and is actively discussed in the field. A new study in PLOS Biology describes a novel marker for an OPC subpopulation that controls oligodendrogenesis and myelination.
Externí odkaz:
https://doaj.org/article/d56b04dc7961469f9320d041a0db5283
Autor:
Sophie B. Siems, Olaf Jahn, Laura J. Hoodless, Ramona B. Jung, Dörte Hesse, Wiebke Möbius, Tim Czopka, Hauke B. Werner
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice. Much less is known about the protein composition of myelin in non-mammalian
Externí odkaz:
https://doaj.org/article/486fb004ccc74129b84575eace012160
Autor:
Rosario Sanchez-Gonzalez, Christina Koupourtidou, Tjasa Lepko, Alessandro Zambusi, Klara Tereza Novoselc, Tamara Durovic, Sven Aschenbroich, Veronika Schwarz, Christopher T. Breunig, Hans Straka, Hagen B. Huttner, Martin Irmler, Johannes Beckers, Wolfgang Wurst, Andreas Zwergal, Tamas Schauer, Tobias Straub, Tim Czopka, Dietrich Trümbach, Magdalena Götz, Stefan H. Stricker, Jovica Ninkovic
Publikováno v:
Cells, Vol 11, Iss 3, p 520 (2022)
The oligodendrocyte progenitors (OPCs) are at the front of the glial reaction to the traumatic brain injury. However, regulatory pathways steering the OPC reaction as well as the role of reactive OPCs remain largely unknown. Here, we compared a long-
Externí odkaz:
https://doaj.org/article/ffd5f82ffd6646c5bfe4032d8fe5b8d0
Publikováno v:
bioRxiv
Xiao, Y, Petrucco, L, Hoodless, L J, Portugues, R & Czopka, T 2022, ' Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling ', Nature Neuroscience . https://doi.org/10.1038/s41593-022-01023-7
Nature Neuroscience
Xiao, Y, Petrucco, L, Hoodless, L J, Portugues, R & Czopka, T 2022, ' Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling ', Nature Neuroscience . https://doi.org/10.1038/s41593-022-01023-7
Nature Neuroscience
Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8cb392c6db812608c98b0449886e8df
https://doi.org/10.1038/s41593-022-01023-7
https://doi.org/10.1038/s41593-022-01023-7
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178058 (2017)
Demyelination is observed in numerous diseases of the central nervous system, including multiple sclerosis (MS). However, the endogenous regenerative process of remyelination can replace myelin lost in disease, and in various animal models. Unfortuna
Externí odkaz:
https://doaj.org/article/d134e3b44fe74810a45c82964b60c06b
SUMMARYIn the nervous system, only one type of neuron-glial synapse is known to exist: that between neurons and oligodendrocyte precursor cells (OPCs). Neuron-OPC synapses are thought to bridge neuronal activity to OPCs. However, their composition, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::640085546aeff46515daf9fd803d68b9
https://doi.org/10.1101/2022.03.18.484955
https://doi.org/10.1101/2022.03.18.484955
Autor:
Gonçalo Castelo-Branco, Laura Jane Hoodless, Tobias Hoche, Tim Czopka, Franziska Auer, Roberta Marisca, Wenke Barkey, Eneritz Agirre
Publikováno v:
Nature Neuroscience
Nature neuroscience
Nature neuroscience
SummaryRecent reports revealed heterogeneity of oligodendrocyte precursor cells (OPCs). It remains unclear if heterogeneity reflects different types of cells with distinct functions, or rather transiently acquired states of cells with the same functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c418e5e4f42a3a3a81acf5e7862dbc
https://doi.org/10.1038/s41593-019-0581-2
https://doi.org/10.1038/s41593-019-0581-2
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Communications Biology
Tian, W, Czopka, T & López-Schier, H 2020, ' Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration ', Communications biology, vol. 3, no. 1, pp. 49 . https://doi.org/10.1038/s42003-020-0776-9
Comm. Biol. 3:49 (2020)
Communications Biology
Tian, W, Czopka, T & López-Schier, H 2020, ' Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration ', Communications biology, vol. 3, no. 1, pp. 49 . https://doi.org/10.1038/s42003-020-0776-9
Comm. Biol. 3:49 (2020)
Protecting the nervous system from chronic effects of physical and chemical stress is a pressing clinical challenge. The obligate pro-degenerative protein Sarm1 is essential for Wallerian axon degeneration. Thus, blocking Sarm1 function is emerging a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acecc6c122faa84f32dafb0af017256
http://link.springer.com/article/10.1038/s42003-020-0776-9
http://link.springer.com/article/10.1038/s42003-020-0776-9
SummaryThe spacing of nodes of Ranvier crucially affects conduction properties along myelinated axons. It has been assumed that node position is primarily driven by the growth of myelin sheaths. Here, we reveal an additional mechanism of node positio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::210b9b68dff2c1841d17639e0b415c01
https://doi.org/10.1101/2021.06.25.449890
https://doi.org/10.1101/2021.06.25.449890
Autor:
Markus H. Schwab, Tatjana Kleele, Stefan Engelhardt, Yan Xiao, Thomas Misgeld, Tim Czopka, Diane L. Sherman, Monika S. Brill, Gabriela Plucińska, Matthias Kneussel, Peter J. Brophy, Mengzhe Wang, Petros Avramopoulos
Publikováno v:
The journal of cell biology 220(4), e201911114 (2021). doi:10.1083/jcb.201911114
Wang, M, Kleele, T, Xiao, Y, Plucinska, G, Avramopoulos, P, Engelhardt, S, Schwab, M H, Kneussel, M, Czopka, T, Sherman, D, Brophy, P J, Misgeld, T & Brill, M S 2021, ' Completion of neuronal remodeling prompts myelination along developing motor axon branches ', Journal of Cell Biology . https://doi.org/10.1083/jcb.201911114
The Journal of Cell Biology
Wang, M, Kleele, T, Xiao, Y, Plucinska, G, Avramopoulos, P, Engelhardt, S, Schwab, M H, Kneussel, M, Czopka, T, Sherman, D, Brophy, P J, Misgeld, T & Brill, M S 2021, ' Completion of neuronal remodeling prompts myelination along developing motor axon branches ', Journal of Cell Biology . https://doi.org/10.1083/jcb.201911114
The Journal of Cell Biology
Postnatal motor neurons undergo extensive competitive remodeling and synchronously myelinate. Wang et al. now reveal that axon remodeling and myelination intersect. While myelination does not predetermine competition outcome, completing remodeling al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb1d60a36096529a25017c77f4762a1