Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Tim Crul"'
Autor:
Viktória Szabó, Noémi Csákány-Papp, Marietta Görög, Tamara Madácsy, Árpád Varga, Aletta Kiss, Bálint Tél, Boldizsár Jójárt, Tim Crul, Krisztina Dudás, Mária Bagyánszki, Nikolett Bódi, Ferhan Ayaydin, Shyam Jee, László Tiszlavicz, Kenneth A. Stauderman, Sudarshan Hebbar, Petra Pallagi, József Maléth
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Patients with recurrent acute pancreatitis (RAP) are at significant risk of developing early chronic pancreatitis (CP), which progresses into irreversible, end-stage CP with severe symptoms. There is no specific therapy in RAP or in early CP that may
Externí odkaz:
https://doaj.org/article/44d41bf76b214028ae93202ee2715468
Autor:
Tim Crul, József Maléth
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4703 (2021)
In eukaryotic cells, ultimate specificity in activation and action—for example, by means of second messengers—of the myriad of signaling cascades is primordial. In fact, versatile and ubiquitous second messengers, such as calcium (Ca2+) and cycli
Externí odkaz:
https://doaj.org/article/72e7158d72c741deb434150824415d0d
Autor:
Tim Crul, Balint Csoboz, Imre Gombos, Annamaria Marton, Maria Peter, Gabor Balogh, Csaba Vizler, Lajos Szente, Laszlo Vigh
Publikováno v:
Cells, Vol 9, Iss 4, p 951 (2020)
The heat shock response (HSR) regulates induction of stress/heat shock proteins (HSPs) to preserve proteostasis during cellular stress. Earlier, our group established that the plasma membrane (PM) acts as a sensor and regulator of HSR through changes
Externí odkaz:
https://doaj.org/article/96c74576e9b8457ba7b9437261eb71d9
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 1, p 325 (2018)
Neurodegenerative diseases (NDDs) such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease (HD), amyotrophic lateral sclerosis, and prion diseases are all characterized by the accumulation of protein aggregates (amyloids) into
Externí odkaz:
https://doaj.org/article/05253d9a9e304b43a842316085aec4e6
Autor:
Burcin Gungor, Imre Gombos, Tim Crul, Ferhan Ayaydin, László Szabó, Zsolt Török, Lajos Mátés, László Vígh, Ibolya Horváth
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89136 (2014)
Eukaryotic cells exhibit a characteristic response to hyperthermic treatment, involving morphological and cytoskeletal alterations and the induction of heat shock protein synthesis. Small GTPases of the Ras superfamily are known to serve as molecular
Externí odkaz:
https://doaj.org/article/4c0a9a1918c1435a89bb485acaeef9d8
Autor:
Imre Gombos, Tim Crul, Stefano Piotto, Burcin Güngör, Zsolt Török, Gábor Balogh, Mária Péter, J Peter Slotte, Federica Campana, Ana-Maria Pilbat, Akos Hunya, Noémi Tóth, Zsuzsanna Literati-Nagy, László Vígh, Attila Glatz, Mario Brameshuber, Gerhard J Schütz, Andrea Hevener, Mark A Febbraio, Ibolya Horváth
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28818 (2011)
Aging and pathophysiological conditions are linked to membrane changes which modulate membrane-controlled molecular switches, causing dysregulated heat shock protein (HSP) expression. HSP co-inducer hydroxylamines such as BGP-15 provide advanced ther
Externí odkaz:
https://doaj.org/article/540052c5363f4c97ba99ccc08cdb8b0e
Autor:
Petra Pallagi, Marietta Görög, Noémi Papp, Tamara Madácsy, Árpád Varga, Tim Crul, Viktória Szabó, Melinda Molnár, Krisztina Dudás, Anna Grassalkovich, Edit Szederkényi, György Lázár, Viktória Venglovecz, Péter Hegyi, József Maléth
Publikováno v:
The journal of physiology A publication of the Physiological Society.
Regardless of its aetiology, sustained intracellular Ca
Autor:
Samu V. Himanen, László Vígh, Ferenc Ötvös, Noémi Tóth, Lea Sistonen, Tim Crul, Marek A. Budzynski
Publikováno v:
Cell Stress & Chaperones
Defects in cellular protein homeostasis are associated with many severe and prevalent pathological conditions such as neurodegenerative diseases, muscle dystrophies, and metabolic disorders. One way to counteract these defects is to improve the prote
Autor:
László Vígh, Mária Péter, Gábor Balogh, Annamária Marton, Tim Crul, Lajos Szente, Csaba Vizler, Bálint Csoboz, Imre Gombos
Publikováno v:
Cells
Volume 9
Issue 4
Cells, Vol 9, Iss 951, p 951 (2020)
Volume 9
Issue 4
Cells, Vol 9, Iss 951, p 951 (2020)
The heat shock response (HSR) regulates induction of stress/heat shock proteins (HSPs) to preserve proteostasis during cellular stress. Earlier, our group established that the plasma membrane (PM) acts as a sensor and regulator of HSR through changes
Publikováno v:
Current Alzheimer research. 15(13)
Lipids participate in Amyloid Precursor Protein (APP) trafficking and processing - important factors in the initiation of Alzheimer’s disease (AD) pathogenesis and influence the formation of neurotoxic β-amyloid (Aβ) peptides. An important risk f