Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Tim Chi"'
Autor:
Anthony W.S. Chan, In Ki Cho, Chun-Xia Li, Xiaodong Zhang, Sudeep Patel, Rebecca Rusnak, Jessica Raper, Jocelyne Bachevalier, Sean P. Moran, Tim Chi, Katherine H. Cannon, Carissa E. Hunter, Ryan C. Martin, Hailian Xiao, Shang-Hsun Yang, Sanjeev Gumber, James G. Herndon, Rebecca F. Rosen, William T. Hu, James J. Lah, Allan I. Levey, Yoland Smith, Lary C. Walker
Publikováno v:
Aging Brain, Vol 2, Iss , Pp 100044- (2022)
With the ultimate goal of developing a more representative animal model of Alzheimer's disease (AD), two female amyloid-β-(Aβ) precursor protein-transgenic (APPtg) rhesus monkeys were generated by lentiviral transduction of the APP gene into rhesus
Externí odkaz:
https://doaj.org/article/e37b891206f5479e91e23e9f894ea295
Autor:
Anthony W S Chan, Jie Jiang, Yiju Chen, Chunxia Li, Melinda S Prucha, Yijuan Hu, Tim Chi, Sean Moran, Tayeb Rahim, Shihua Li, Xiaojiang Li, Stuart M Zola, Claudia M Testa, Hui Mao, Rosa Villalba, Yoland Smith, Xiaodong Zhang, Jocelyne Bachevalier
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0122335 (2015)
One of the roadblocks to developing effective therapeutics for Huntington disease (HD) is the lack of animal models that develop progressive clinical traits comparable to those seen in patients. Here we report a longitudinal study that encompasses co
Externí odkaz:
https://doaj.org/article/e416b6c611374cee97ca7a70bf7d021c
Autor:
William G Dixon, Sabine N van der Veer, Syed Mustafa Ali, Lynn Laidlaw, Richard J B Dobson, Cathie Sudlow, Tim Chico, Jacqueline A L MacArthur, Aiden Doherty
Publikováno v:
Journal of Medical Internet Research, Vol 25, p e42449 (2023)
The use of data from smartphones and wearable devices has huge potential for population health research, given the high level of device ownership; the range of novel health-relevant data types available from consumer devices; and the frequency and du
Externí odkaz:
https://doaj.org/article/833beebbaab34bbaac8090a5237122b6
Autor:
Sherrie Jean, Melinda S. Prucha, Sean P. Moran, Kenneth G. Gould, Kwang Sung Ahn, Tim Chi, Anthony W.S. Chan, Fawn Connor-Stroud
Transgenic nonhuman primate models are increasingly popular model for neurological and neurodegenerative disease because their brain functions and neural anatomies closely resemble those of humans [1–6]. Transgenic Huntington’s disease monkeys (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210afc42c25e72b8efcb6aba93f5bd06
https://europepmc.org/articles/PMC4631054/
https://europepmc.org/articles/PMC4631054/
Autor:
Stuart M. Zola, Jocelyne Bachevalier, Anthony W.S. Chan, Claudia M. Testa, Sean P. Moran, Hui Mao, Melinda S. Prucha, Tayeb Rahim, Chun-Xia Li, Yi-Juan Hu, Rosa M. Villalba, Shihua Li, Jie Jiang, Xiaodong Zhang, Yiju Chen, Tim Chi, Xiao-Jiang Li, Yoland Smith
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 5, p e0122335 (2015)
PLoS ONE, Vol 10, Iss 5, p e0122335 (2015)
One of the roadblocks to developing effective therapeutics for Huntington disease (HD) is the lack of animal models that develop progressive clinical traits comparable to those seen in patients. Here we report a longitudinal study that encompasses co
Autor:
Christophe Royer, Elizabeth Sandham, Elizabeth Slee, Falk Schneider, Christoffer B. Lagerholm, Jonathan Godwin, Nisha Veits, Holly Hathrell, Felix Zhou, Karolis Leonavicius, Jemma Garratt, Tanaya Narendra, Anna Vincent, Celine Jones, Tim Child, Kevin Coward, Chris Graham, Marco Fritzsche, Xin Lu, Shankar Srinivas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The early embryo maintains its structure in the face of large mechanical stresses during morphogenesis. Here they show that ASPP2 acts to preserve epithelial integrity in regions of high apical tension during early development.
Externí odkaz:
https://doaj.org/article/28cde804539b4aaba4e1341177ac28d1
Publikováno v:
Asian Journal of Andrology, Vol 24, Iss 4, Pp 345-352 (2022)
Phospholipase C zeta (PLCζ) is a sperm-specific protein that triggers oocyte activation. The analysis of PLCζ expression in human spermatozoa can be used as a diagnostic marker for oocyte activation deficiency. Our laboratory has previously optimiz
Externí odkaz:
https://doaj.org/article/1da68295569e4e319894bd05209c6e0c
Autor:
Abha Maheshwari, Vasha Bari, Jennifer L Bell, Siladitya Bhattacharya, Priya Bhide, Ursula Bowler, Daniel Brison, Tim Child, Huey Yi Chong, Ying Cheong, Christina Cole, Arri Coomarasamy, Rachel Cutting, Fiona Goodgame, Pollyanna Hardy, Haitham Hamoda, Edmund Juszczak, Yacoub Khalaf, Andrew King, Jennifer J Kurinczuk, Stuart Lavery, Clare Lewis-Jones, Louise Linsell, Nick Macklon, Raj Mathur, David Murray, Jyotsna Pundir, Nick Raine-Fenning, Madhurima Rajkohwa, Lynne Robinson, Graham Scotland, Kayleigh Stanbury, Stephen Troup
Publikováno v:
Health Technology Assessment, Vol 26, Iss 25 (2022)
Background: Freezing all embryos, followed by thawing and transferring them into the uterine cavity at a later stage (freeze-all), instead of fresh-embryo transfer may lead to improved pregnancy rates and fewer complications during in vitro fertil
Externí odkaz:
https://doaj.org/article/6a650d6006144e4a9a549fb285eb2285
Publikováno v:
International Journal of Fertility and Sterility, Vol 14, Iss 2, Pp 137-142 (2020)
Background This study intends to present the role of rescue in vitro maturation (IVM) in polycystic ovarian syn- drome (PCOS) patients undergoing in vitro fertilization (IVF) treatment who have inappropriate responses to ovarian stimulation. Material
Externí odkaz:
https://doaj.org/article/05a0c8cfd7724384ade236dff77f5de0
Publikováno v:
Reproduction, Fertility and Development. 26:144
Cryopreservation is an important tool routinely used for preserving sperm for artificial reproductive technologies (ART), as well as genetic preservation of unique animal models. The cryopreservation process is harsh and detrimental to the fragile ga